Nanomaterials for Radiation Therapy

Sheng, Ke; Yang, Wensha

doi:10.1002/9783527610419.ntls0197

Cited by 3 publications

(3 citation statements)

References 137 publications

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“…Compared with the 1 O 2 from 50 J cm −2 of blue laser light, the amount of singlet oxygen is approximately one order of magnitude lower with 6 Gy of radiation. The experimental results agree with previous theoretical estimations [28,29].…”

Section: Resultssupporting

confidence: 91%

Tumor cell apoptosis induced by nanoparticle conjugate in combination with radiation therapy

et al. 2010

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Semiconductor nanoparticles conjugated to photosensitizers have been shown to increase tumor cell death with ionizing radiation but the mechanism, particularly the role of photodynamic therapy in the process, was unknown. We used a molecular probe to measure production of (1)O(2) to quantify the component of photodynamic cell-killing in an in vitro system. The intracellular distribution of the nanoparticle conjugate (NC) was determined by the co-localization of nanoparticles and the lysotracker. Induction of apoptosis was measured by the TUNEL assay and western blot analysis of the cleaved caspase-3. As a result, dose-dependent (1)O(2) production was observed with 48 nm NC after irradiating with 6 MV x-rays. A high geometrical coincidence between the fluorescence emission of the nanoparticle and lysotracker was observed using confocal microscopy. Finally, apoptosis, as indicated by the TUNEL stain and cleavage of the caspase-3, was observed in cells treated by both the NC and 6 Gy of radiation but not in cells treated with radiation alone. In conclusion, the cell death induced by the NC in combination with radiation is consistent with a supra-additive effect to radiation-or NC-alone-killing and is mediated by an NC-induced photodynamic therapy mechanism, which is distinctly different from that for radiation-killing alone. By providing a second distinct cell-killing mechanism, this nanoparticle conjugate has great promise as a targeted physical radiosensitizer aimed at overcoming radioresistant tumor clonogens or/and reducing normal tissue toxicity by using a lower ionizing radiation dose.

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Section: Resultssupporting

confidence: 91%

Tumor cell apoptosis induced by nanoparticle conjugate in combination with radiation therapy

et al. 2010

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“…Therefore, gold nanoparticles have being used easily. Shang and Yang [11] state that 0.00 ml/g of +1.9mm or -1.9 mm nanoparticles are injected into the mice's tail vein, in the xenograft tumor, the gold nanoparticles can be observed in a short time. Hence gold nanoparticles can be used radiotherapy.…”

Section: Nanotechnology In Cancer Treatmentmentioning

confidence: 99%

Nanotechnology in Cancer Treatment

Aliosmanoglu¹

2012

J Nanomedine Biotherapeutic Discov

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Nanotechnology is rapidly developing subdivision of technology that affects on many fields. Medicine is also affected from nanotechnology; since, in cancer treatment nanotechnologically modified methods can be used. One of the developing usage fields of nanotechnology is cancer treatment. Nanotechnology can assist to have better diagnosis with less harmful substances as optical nanoparticles and ICG molecules, to provide efficient drug delivery to tumor cells with liposomes and functionalized micelles. Nanotechnology can be also used in molecular imaging with tomography and photoacoustic imaging of tumors and therapy of cancer as photothermal and radiotherapy. Finally, nanotechnology is still developing science can be defined as next generation techniques for cancer disease; at the same time it comes with many advantages to treat cancer patients.

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“…In addition to these, nanobiomaterials are also used for antimicrobial activities [50][51][52] . The emerging applications are found in cancer diagnosis and therapy [53][54][55][56][57][58] , for detecting and treating tumors 59 , photodynamic therapy [60][61] , tuberculosis 62 and dental implants 63 . Nanobiomaterials are suitable tags for cellular detections, in cell and molecular biology [64][65] .…”

Section: Nanobiomaterials (Nbm) and Their Categoriesmentioning

confidence: 99%

Untitled

2017

IJPSR

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Nanobiomaterials are very effective components for several biomedical and pharmaceutical studies. Among the metallic, organic, ceramic and polymeric nanomaterials, metallic nanomaterials have shown certain prominent biomedical applications. Enormous works have been done to synthesize, analyse and administer the metallic nanoparticles for various kinds of medical and therapeutic applications, during the last forty years. In these analyses, the prominent biomedical applications of ten metallic nanobiomaterials have been reviewed from various sources and works. It has been found that almost nine of them are used in a very wide spectrum of medical and theranostic applications.

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Nanomaterials for Radiation Therapy

Abstract: The sections in this article are Introduction A Brief Introduction to Radiation Therapy, and its Limitations Physical Radiosensitizers Enhanced Radiation Therapy Using High Z but Non‐Nanoscaled Materials Enhanced Radiation Therapy by Gold Nanoparticles … Show more

Cited by 3 publications

References 137 publications

Tumor cell apoptosis induced by nanoparticle conjugate in combination with radiation therapy

Tumor cell apoptosis induced by nanoparticle conjugate in combination with radiation therapy

Nanotechnology in Cancer Treatment

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