Nanomaterials for diabetic wound healing: Visualization and bibliometric analysis from 2011 to 2021

Abstract

BackgroundNanomaterials have recently been shown to have a considerable advantage in promoting wound healing in diabetic patients or animal models. However, no bibliometric analysis has been conducted to evaluate global scientific production. Herein, this study aimed to summarize the current characteristics, explore research trends, and clarify the direction of nanomaterials and diabetic wound healing in the future.MethodsRelevant publications from 2011 to 2021 were collected from the Web of Science Core Collection on October 3, 2022. VOSviewer, CiteSpace, bibliometrix-R package, Origin 2021, and Microsoft Excel 2019 were used for bibliometric and visualization analyses.ResultsWe identified 409 publications relating to nanomaterials and diabetic wound healing. The number of annual productions remarkably increased from 2011 to 2021, with China and Shanghai Jiao Tong University being the most productive. The most prolific authors were Hasan Anwarul. The leading journal was the International Journal of Biological Macromolecules, with 22 publications. The most popular keywords were “nanoparticles,” “delivery,” “in vitro,” “electrospinning,” “angiogenesis,” and “antibacterial.” Keyword burst analysis showed “cerium oxide,” “matrix metalloproteinase 9,” “composite nanofiber,” “hif 1 alpha,” and “oxide nanoparticle” were emerging research hotspots.ConclusionWe found there has been a great progress in the application of nanomaterials in diabetic wound healing from 2011 to 2021. Although many researchers and institutions from different countries or regions contributed contributed to publications, it will be helpful or the development of this field if the degree of international cooperation can be enhanced. In the future, nanomaterials with powerful antioxidant and antibacterial qualities and promoting angiogenesis are the research hotspots.

Visualization of the relationship between macrophage and wound healing from the perspective of bibliometric analysis

“…Subsequently, they highlighted that treatment strategies involving extracellular vesicles during the wound healing process emerged as pivotal research foci within this domain. In line with this, several other bibliometric studies also explored the role of biofilms, 24 nanomaterials, 25 as well as curcumin 26 in wound healing. However, as far as our understanding goes, there has not been any bibliometric analysis conducted to explore the worldwide research trends within the field of macrophage and wound healing.…”

Visualizing the global trends of peptides in wound healing through an in‐depth bibliometric analysis

“…CiteSpace is a Java‐based bibliometric analysis tool that is widely utilized for the visual exploration of scientific literature and helps to discover research hotspots and future trends. 39 , 40 Network visualisation in CiteSpace demonstrates how knowledge is managed, organized, and dispersed. In this study, we used CiteSpace (version 6.1.…”

Bioinspired 3D-printed scaffold embedding DDAB-nano ZnO/nanofibrous microspheres for regenerative diabetic wound healing

“…Apart from antibiotics [11,12], newer agents such as antimicrobial peptides and peptide-based polymers [13], phytochemicals [14,15] and inorganic nanomaterials such as silver nanoclusters [16], Au-based nanoparticles (NPs) [17], and metal oxide NPs, e.g. zinc oxide [15], magnesium oxide, cerium oxide and ferric oxide NPs [18] are currently emerging as effective bioactives capable of preventing infection, reducing bacterial resistance and promoting healing of acute and diabetic wounds. Different composites made of polymeric biomaterials and antimicrobial metal-based nanostructures, such as Ag NPs and ZNP as substitutes for antibiotics, inhibit bacterial growth with simultaneous acceleration of the healing process [19].…”