Nanomaterials for chronic inflammatory diseases: the current status and future prospects

Oshi, Murtada A.; Haider, Adnan; Siddique, Muhammad Irfan; Zeb, Alam; Jamal, Syed Babar; Naeem, Muhammad

doi:10.1007/s13204-021-02019-8

Cited by 7 publications

(4 citation statements)

References 101 publications

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“…A 2022 study revealed the potential role of a microbial dye in combination with multiple low doses of gamma radiation exhibiting anti‐inflammatory effects and reducing disease severity in adjuvant induced arthritis rats (Abdel‐Rafei et al, 2022). Alternatively, nano‐carriers have also been explored for drug delivery against chronic inflammatory diseases (Oshi et al, 2022; Gorantla et al, 2020; Donthi et al, 2023). Recently, dendrimers have gained attention for their narrow polydispersity index (Dubey et al, 2021).…”

Section: Novel Potential Therapeutic Strategies Emerging Against Ramentioning

confidence: 99%

“…However, there have been advancements in the surgical sector such as prophylactic antibiotics and laminar airflow on the wound to prevent contamination, reducing joint infection incidences to a low 2%-2.4% (Goodman, 2015b). Alternatively, nano-carriers have also been explored for drug delivery against chronic inflammatory diseases (Oshi et al, 2022;Gorantla et al, 2020;Donthi et al, 2023). Recently, dendrimers have gained attention for their narrow polydispersity index (Dubey et al, 2021).…”

Section: Surgerymentioning

confidence: 99%

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Comprehensive insights into rheumatoid arthritis: Pathophysiology, current therapies and herbal alternatives for effective disease management

Chatterjee,

Jayaprakasan,

Chakrabarty

et al. 2024

Phytotherapy Research

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Rheumatoid arthritis is a chronic autoimmune inflammatory disease characterized by immune response overexpression, causing pain and swelling in the synovial joints. This condition is caused by auto‐reactive antibodies that attack self‐antigens due to their incapacity to distinguish between self and foreign molecules. Dysregulated activity within numerous signalling and immunological pathways supports the disease's development and progression, elevating its complexity. While current treatments provide some alleviation, their effectiveness is accompanied by a variety of adverse effects that are inherent in conventional medications. As a result, there is a deep‐rooted necessity to investigate alternate therapeutic strategies capable of neutralizing these disadvantages. Medicinal herbs display a variety of potent bioactive phytochemicals that are effective in the complementary management of disease, thus generating an enormous potency for the researchers to delve deep into the development of novel phytomedicine against autoimmune diseases, although additional evidence and understanding are required in terms of their efficacy and pharmacodynamic mechanisms. This literature‐based review highlights the dysregulation of immune tolerance in rheumatoid arthritis, analyses the pathophysiology, elucidates relevant signalling pathways involved, evaluates present and future therapy options and underscores the therapeutic attributes of a diverse array of medicinal herbs in addressing this severe disease.

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Section: Novel Potential Therapeutic Strategies Emerging Against Ramentioning

confidence: 99%

Section: Surgerymentioning

confidence: 99%

Comprehensive insights into rheumatoid arthritis: Pathophysiology, current therapies and herbal alternatives for effective disease management

Chatterjee,

Jayaprakasan,

Chakrabarty

et al. 2024

Phytotherapy Research

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“…Nanomaterials have been extensively reported for the treatment of various diseases including cancer, obesity, diabetes, inflammatory disorders, and cardiovascular diseases . However, one of the greatest challenges that hampered clinical transformations lies in insufficient tissue penetration of these functional nanomaterials, resulting in unsatisfying therapeutic efficacy .…”

Section: Introductionmentioning

confidence: 99%

Self-Propelled Janus Nanocatalytic Robots Guided by Magnetic Resonance Imaging for Enhanced Tumor Penetration and Therapy

Sun

Wang

et al. 2023

J. Am. Chem. Soc.

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Biomedical micro/nanorobots as active delivery systems with the features of self-propulsion and controllable navigation have made tremendous progress in disease therapy and diagnosis, detection, and biodetoxification. However, existing micro/nanorobots are still suffering from complex drug loading, physiological drug stability, and uncontrollable drug release. To solve these problems, micro/nanorobots and nanocatalytic medicine as two independent research fields were integrated in this study to achieve self-propulsion-induced deeper tumor penetration and catalytic reaction-initiated tumor therapy in vivo. We presented self-propelled Janus nanocatalytic robots (JNCRs) guided by magnetic resonance imaging (MRI) for in vivo enhanced tumor therapy. These JNCRs exhibited active movement in H2O2 solution, and their migration in the tumor tissue could be tracked by non-invasive MRI in real time. Both increased temperature and reactive oxygen species production were induced by near-infrared light irradiation and iron-mediated Fenton reaction, showing great potential for tumor photothermal and chemodynamic therapy. In comparison with passive nanoparticles, these self-propelled JNCRs enabled deeper tumor penetration and enhanced tumor therapy after intratumoral injection. Importantly, these robots with biocompatible components and byproducts exhibited biosecurity in the mouse model. It is expected that our work could promote the combination of micro/nanorobots and nanocatalytic medicine, resulting in improved tumor therapy and potential clinical transformations.

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“…[4][5][6] Most affected has been cancer treatment due to the development of a variety therapeutic agents designed with molecular precision for the treatment of specific cancer genotypes. 7 Additionally, advances in diagnostics and treatment of, e.g., reproductive diseases, 8 Alzheimer's, 9 infectious disease, 10 cardiovascular disease, 11 viral diseases, 12 chronic inflammation, 13 and neurodegenerative diseases 14 have showcased the utility of nanomedicine in a broad range of diseases. At its core the advantage of nanomedicine lies in the tunability of nanomaterials which allow for highly versatile and multifunctional therapeutic agents, often referred to as personalized medicines (Fig.…”

Section: Introductionmentioning

confidence: 99%

Recent advancements in design of nucleic acid nanocarriers for controlled drug delivery

2023

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Nanomaterials for chronic inflammatory diseases: the current status and future prospects

Cited by 7 publications

References 101 publications

Comprehensive insights into rheumatoid arthritis: Pathophysiology, current therapies and herbal alternatives for effective disease management

Comprehensive insights into rheumatoid arthritis: Pathophysiology, current therapies and herbal alternatives for effective disease management

Self-Propelled Janus Nanocatalytic Robots Guided by Magnetic Resonance Imaging for Enhanced Tumor Penetration and Therapy

Recent advancements in design of nucleic acid nanocarriers for controlled drug delivery

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