Nanomaterials‐Enabled Physicochemical Antibacterial Therapeutics: Toward the Antibiotic‐Free Disinfections

Xing, Zhenyu; Guo, Jiusi; Wu, Zihe; He, Chao; Wang, Liyun; Bai, Mingru; Liu, Xikui; Zhu, Bihui; Guan, Qiuyue; Cheng, Chong

doi:10.1002/smll.202303594

Cited by 9 publications

(1 citation statement)

References 286 publications

(440 reference statements)

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“…These properties arise from the interactions between nanomaterials and bacteria, which result in the destruction of cell structures and eventual bacterial death. The physical antibacterial properties of nanomaterials, such as morphology, optics, thermology, and mechanics, play a crucial role in this process [ 13 , 14 ]. For instance, the nanostructure on the surface of cicada wings exhibits a great bactericidal effect on Pseudomonas aeruginosa (P. aeruginosa) through physical cutting [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial micro/nanomotors: advancing biofilm research to support medical applications

Jiang,

Fu,

Wei

et al. 2023

J Nanobiotechnol

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Multi-drug resistant (MDR) bacterial infections are gradually increasing in the global scope, causing a serious burden to patients and society. The formation of bacterial biofilms, which is one of the key reasons for antibiotic resistance, blocks antibiotic penetration by forming a physical barrier. Nano/micro motors (MNMs) are micro-/nanoscale devices capable of performing complex tasks in the bacterial microenvironment by transforming various energy sources (including chemical fuels or external physical fields) into mechanical motion or actuation. This autonomous movement provides significant advantages in breaking through biological barriers and accelerating drug diffusion. In recent years, MNMs with high penetrating power have been used as carriers of antibiotics to overcome bacterial biofilms, enabling efficient drug delivery and improving the therapeutic effectiveness of MDR bacterial infections. Additionally, non-antibiotic antibacterial strategies based on nanomaterials, such as photothermal therapy and photodynamic therapy, are continuously being developed due to their non-invasive nature, high effectiveness, and non-induction of resistance. Therefore, multifunctional MNMs have broad prospects in the treatment of MDR bacterial infections. This review discusses the performance of MNMs in the breakthrough and elimination of bacterial biofilms, as well as their application in the field of anti-infection. Finally, the challenges and future development directions of antibacterial MNMs are introduced.

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Section: Introductionmentioning

confidence: 99%

Antibacterial micro/nanomotors: advancing biofilm research to support medical applications

Jiang,

Fu,

Wei

et al. 2023

J Nanobiotechnol

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ROS‐Responsive Core‐Shell Microneedles Based on Simultaneous Efficient Type I/II Photosensitizers for Photodynamic Against Bacterial Biofilm Infections

Li,

Zheng,

Gao

et al. 2024

Adv Funct Materials

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Antimicrobial photodynamic therapy (aPDT) has emerged as an appealing therapeutic option against biofilm infections. However, effectively penetrating the dense barrier of biofilm and anchoring bacteria to achieve biofilm elimination and wound healing under hypoxic environments remains a challenge for aPDT. Herein, three type I/II Hypocrellin B (HB)‐cationic photosensitizers (HB‐P, HB‐TP, and HB‐TTP) are designed based on a multi‐cationic long chains molecular engineering strategy. With an increasing number of introduced cations, the reactive oxygen species (ROS) production and bacterial‐anchoring abilities of HB‐cationic photosensitizers are greatly enhanced. Notably, HB‐TTP demonstrates higher type I/II aPDT activity and broad‐spectrum antibacterial properties. Furthermore, to effectively address the conundrum of healing biofilm‐infected wounds, a ROS‐responsive core‐shell microneedle (HB‐TTP&EGF@MN) is designed by biphasically integrating HB‐TTP and growth factor. When the microneedle penetrates biofilm, the shell quickly dissolves and releases HB‐TTP to achieve biofilm removal under laser irradiation. The core is subsequently degraded slowly in the presence of endogenous ROS within the wound, facilitating a sustained release of growth factor to promote wound tissue regeneration. This work not only provides an effective strategy for the rational design of efficient antimicrobial agents but also proposes innovative ideas for the development of controlled‐release pharmaceutical materials to synergize against biofilm infections.

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Supramolecular Assembly Based on Calix(4)arene and Aggregation‐Induced Emission Photosensitizer for Phototherapy of Drug‐Resistant Bacteria and Skin Flap Transplantation

Wang,

Liu,

Wang

et al. 2024

Adv Healthcare Materials

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Photodynamic therapy as a burgeoning and non‐invasive theranostic technique has drawn great attention in the field of antibacterial treatment, but often encounters undesired phototoxicity of photosensitizers during systemic circulation. Herein, a supramolecular substitution strategy is proposed for phototherapy of drug‐resistant bacteria and skin flap repair by using macrocyclic p‐sulfonatocalix[4]arene (SC4A) as a host, and two cationic AIEgens, namely TPE‐QAS and TPE‐2QAS, bearing quaternary ammonium group(s) as guests. Through host‐guest assembly, the obtained complex exhibits obvious blue fluorescence in the solution due to restriction of free motion of AIEgens and drastically inhibits efficient type I ROS generation. Then, upon addition of another guest 4,4′‐benzidine dihydrochloride, TPE‐QAS can be competitively replaced from the cavity of SC4A to restore its pristine ROS efficiency and photoactivity in aqueous solution. The dissociative TPE‐QAS shows a high bacterial binding ability with an efficient treatment for methicillin‐resistant Staphylococcus aureus (MRSA) in the dark and light irradiation. Meanwhile, it also exhibits an improved survival rate for MRSA‐infected skin flap transplantation and largely accelerates the healing process. Thus, such cascaded host‐guest assembly is an ideal platform for phototheranostics research.This article is protected by copyright. All rights reserved

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Nanomaterials‐Enabled Physicochemical Antibacterial Therapeutics: Toward the Antibiotic‐Free Disinfections

Cited by 9 publications

References 286 publications

Antibacterial micro/nanomotors: advancing biofilm research to support medical applications

Antibacterial micro/nanomotors: advancing biofilm research to support medical applications

ROS‐Responsive Core‐Shell Microneedles Based on Simultaneous Efficient Type I/II Photosensitizers for Photodynamic Against Bacterial Biofilm Infections

Supramolecular Assembly Based on Calix(4)arene and Aggregation‐Induced Emission Photosensitizer for Phototherapy of Drug‐Resistant Bacteria and Skin Flap Transplantation

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