Nanomaterials-driven innovative electrochemiluminescence aptasensors in reporting food pollutants

Li, Yanping; Gao, Xiang; Fang, Yishan; Cui, Bo; Shen, Yizhong

doi:10.1016/j.ccr.2023.215136

Cited by 45 publications

(10 citation statements)

References 175 publications

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“…Molecular luminescence and electrochemiluminescence (ECL) properties are strongly influenced by the spatial arrangement of chromophores, e.g., by the supramolecular stacking pattern and the way multiple monomers assemble into crystal structures. [1] ECL, i.e., the emission of light due to electrochemical reactions between substances electrogenerated at electrode surfaces, [2] offers the advantages of operational and miniaturization simplicity, absence of excitation light sources, and precise control of reaction kinetics, thus finding applications in clinical diagnostics, [3] environmental monitoring, [4] food security, [5] and immunoassays, [6] and other areas requiring ultrasensitive sensing.…”

Section: Introductionmentioning

confidence: 99%

Precise Modulation of Intramolecular Aggregation‐induced Electrochemiluminescence by Tetraphenylethylene‐based Supramolecular Architectures

Zhu,

Zeng,

Zhao

et al. 2023

Angew Chem Int Ed

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The precisely modulated synthesis of programmable light‐emitting materials remains a challenge. To address this challenge, we construct four tetraphenylethylene‐based supramolecular architectures (SA, SB, SC, and SD), revealing that they exhibit higher electrochemiluminescence (ECL) intensities and efficiencies than the tetraphenylethylene monomer and can be classified as highly efficient and precisely modulated intramolecular aggregation–induced electrochemiluminescence (PI‐AIECL) systems. The best‐performing system (SD) shows a high ECL cathodic efficiency exceeding that of the benchmark tris(2, 2'‐bipyridyl)ruthenium(II) chloride in aqueous solution by nearly six‐fold. The electrochemical characterization of these architectures in an organic solvent provides deeper mechanistic insights, revealing that SD features the lowest electrochemical bandgap. Density functional theory calculations indicate that the bandgap of the guest ligand in the SD structure is the smallest and most closely matched to that of the host scaffold. Finally, the SD system is used to realize ECL‐based cysteine detection (detection limit = 14.4 nM) in real samples. Thus, this study not only provides a precisely modulated supramolecular strategy allowing chromophores to be controllably regulated on a molecular scale, but also inspires the programmable synthesis of high‐performance aggregation‐induced electrochemiluminescence emitters.

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Section: Introductionmentioning

confidence: 99%

Precise Modulation of Intramolecular Aggregation‐induced Electrochemiluminescence by Tetraphenylethylene‐based Supramolecular Architectures

Zhu,

Zeng,

Zhao

et al. 2023

Angew Chem Int Ed

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show abstract

“…With the advantages of controllability, high sensitivity, low background noise, and simple operation, ECL have become a powerful analytical tool in the fields of bioassay, environmental, and food safety (e.g., nucleic acids, proteins, heavy metal ions, toxins, pathogenic bacteria, etc. ). − …”

Section: Introductionmentioning

confidence: 99%

Ultrasensitive Electrochemiluminescence Sensor Utilizing Aggregation-Induced Emission Active Probe for Accurate Arsenite Quantification in Rice Grains

Chen,

Gao,

et al. 2024

J. Agric. Food Chem.

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Arsenic (As) constitutes a substantial threat to global ecosystems and public health. An accurate quantification of inorganic arsenite (As(III)) in rice grains is crucial for ensuring food safety and human well-being. Herein, we constructed an electrochemiluminescence (ECL) biosensor utilizing aggregation-induced emission (AIE) active Pdots for the sensitive detection of As(III) in rice. We synthesized tetraphenylethylene-based AIE-active Pdots, exhibiting stable and highly efficient ECL emission in their aggregated states. Owing to the overlap of spectra, we employed an electrochemiluminescence resonance energy transfer (ECL-RET) system, with the Pdots as the donor and black hole quencher (BHQ) as the acceptor. Upon the introduction of As(III), the conformational changes of As(III)-specific aptamer could trigger the detachment of BHQ-labeled DNA aptamer from the electrode surface, leading to the recovery of the ECL signal. The target-induced "signal-on" bioassay enabled the sensitive and specific detection of As(III) with a linear range of 10 pM to 500 nM, with an ultralow limit of detection (LOD) of 5.8 pM/0.4 ppt. These values significantly surpass those of existing sensors designed for As(III) quantification in rice. Furthermore, by employing amylase hydrolysis for efficient extraction, we successfully applied our sensor to measure As(III) in actual rice samples sourced from diverse regions of China. The results obtained using our sensor were in close agreement with those derived from the reference method of HPLC−ICP−MS. This study not only presents a sensitive and reliable method for detecting arsenite but also underscores its potential applications in enhancing food safety, agriculture practices, and environmental monitoring.

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“…Electrochemiluminescence (ECL) refers to a light emission phenomenon, resulting from electrogenerated species that undergo electron transfer reactions to form excited states. − The ECL technique combines the advantages of electrochemistry and chemiluminescence, offering high sensitivity, satisfactory stability, and low cost. − Consequently, it has garnered considerable attention in fields such as environmental monitoring, clinical diagnosis, − bioimaging, − and food safety . However, when it comes to discriminating complex multicomponent samples, constructing multiple sensors or sensor arrays , and obtaining intuitive results is time-consuming and expensive for analysts. , Dual potential-resolved ECL emission presents a solution by simplifying the preparation process and reducing the likelihood of false errors caused by external factors .…”

Section: Introductionmentioning

confidence: 99%

Regulating Reactive Oxygen Species over M–N–C Single-Atom Catalysts for Potential-Resolved Electrochemiluminescence

Zhou,

Wu,

Luo

et al. 2024

J. Am. Chem. Soc.

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The development of potential-resolved electrochemiluminescence (ECL) systems with dual emitting signals holds great promise for accurate and reliable determination in complex samples. However, the practical application of such systems is hindered by the inevitable mutual interaction and mismatch between different luminophores or coreactants. In this work, for the first time, by precisely tuning the oxygen reduction performance of M−N−C single-atom catalysts (SACs), we present a dual potential-resolved luminol ECL system employing endogenous dissolved O 2 as a coreactant. Using advanced in situ monitoring and theoretical calculations, we elucidate the intricate mechanism involving the selective and efficient activation of dissolved O 2 through central metal species modulation. This modulation leads to the controlled generation of hydroxyl radical (•OH) and superoxide radical (O 2 •− ), which subsequently trigger cathodic and anodic luminol ECL emission, respectively. The well-designed Cu−N−C SACs, with their moderate oxophilicity, enable the simultaneous generation of •OH and O 2 •− , thereby facilitating dual potential-resolved ECL. As a proof of concept, we employed the principal component analysis statistical method to differentiate antibiotics based on the output of the dual-potential ECL signals. This work establishes a new avenue for constructing a potentialresolved ECL platform based on a single luminophore and coreactant through precise regulation of active intermediates.

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Nanomaterials-driven innovative electrochemiluminescence aptasensors in reporting food pollutants

Cited by 45 publications

References 175 publications

Precise Modulation of Intramolecular Aggregation‐induced Electrochemiluminescence by Tetraphenylethylene‐based Supramolecular Architectures

Precise Modulation of Intramolecular Aggregation‐induced Electrochemiluminescence by Tetraphenylethylene‐based Supramolecular Architectures

Ultrasensitive Electrochemiluminescence Sensor Utilizing Aggregation-Induced Emission Active Probe for Accurate Arsenite Quantification in Rice Grains

Regulating Reactive Oxygen Species over M–N–C Single-Atom Catalysts for Potential-Resolved Electrochemiluminescence

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