Nanomaterials-combined methacrylated gelatin hydrogels (GelMA) for cardiac tissue constructs

Lisboa, Erika S.; Serafim, Carine; Santana, Wanessa; dos Santos, Victoria L.S.; de Albuquerque-Junior, Ricardo L.C.; Chaud, Marco V.; Cardoso, Juliana C.; Jain, Sona; Severino, Patrícia; Souto, Eliana B.

doi:10.1016/j.jconrel.2023.11.056

Cited by 3 publications

(1 citation statement)

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“…The advantage of using Gel-MA is that the degree of methacrylation can be modified based on the application; furthermore, given the presence of gelatin, it is the ideal candidate for cell adhesion and growth. The use of Gel-MA, particularly for cardiac tissue engineering, has been covered in detail here [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Hydrogels for Cardio and Vascular Tissue Repair and Regeneration

Motta,

Soccio,

Guidotti

et al. 2024

Gels

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Cardiovascular disease (CVD), the leading cause of death globally, affects the heart and arteries with a variety of clinical manifestations, the most dramatic of which are myocardial infarction (MI), abdominal aortic aneurysm (AAA), and intracranial aneurysm (IA) rupture. In MI, necrosis of the myocardium, scar formation, and loss of cardiomyocytes result from insufficient blood supply due to coronary artery occlusion. Beyond stenosis, the arteries that are structurally and functionally connected to the cardiac tissue can undergo pathological dilation, i.e., aneurysmal dilation, with high risk of rupture. Aneurysms of the intracranial arteries (IAs) are more commonly seen in young adults, whereas those of the abdominal aorta (AAA) are predominantly seen in the elderly. IAs, unpredictably, can undergo rupture and cause life-threatening hemorrhage, while AAAs can result in rupture, internal bleeding and high mortality rate. In this clinical context, hydrogels, three-dimensional networks of water-seizing polymers, have emerged as promising biomaterials for cardiovascular tissue repair or protection due to their biocompatibility, tunable properties, and ability to encapsulate and release bioactive molecules. This review provides an overview of the current state of research on the use of hydrogels as an innovative platform to promote cardiovascular-specific tissue repair in MI and functional recovery or protection in aneurysmal dilation.

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Section: Introductionmentioning

confidence: 99%

Hydrogels for Cardio and Vascular Tissue Repair and Regeneration

Motta,

Soccio,

Guidotti

et al. 2024

Gels

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Injectable Inflammation‐Responsive Hydrogels for Microenvironmental Regulation of Intervertebral Disc Degeneration

Liu,

Wang,

Huang

et al. 2024

Adv Healthcare Materials

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Chronic local inflammation and excessive cell apoptosis in nucleus pulposus (NP) tissue are the main causes of intervertebral disc degeneration (IDD). Stimuli‐responsive hydrogels have great potential in the treatment of IDD by facilitating localized and controlled drug delivery. Herein, we develop an injectable drug‐loaded dual stimuli‐responsive adhesive hydrogel for microenvironmental regulation of IDD. The gelatin methacryloyl is functionalized with phenylboronic acid groups to enhance drug loading capacity and enable dual stimuli‐responsive behavior, while the incorporation of oxidized hyaluronic acid further improves the adhesive properties. The prepared hydrogel exhibits an enhanced drug loading capacity for diol‐containing drugs, pH‐ and reactive oxygen species (ROS)‐responsive behaviors, excellent radical scavenging efficiency, potent antibacterial activity, and favorable biocompatibility. Furthermore, the hydrogel shows a beneficial protective efficacy on NP cells within an in vitro oxidative stress microenvironment. The in vivo results demonstrate the hydrogel's excellent therapeutic effect on treating IDD by maintaining water retention, restoring disc height, and promoting NP regeneration, indicating that this hydrogel holds great potential as a promising therapeutic approach for regulating the microenvironment and alleviating the progression of IDD.This article is protected by copyright. All rights reserved

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