Nanomaterials-based electrochemical immunosensors for cardiac troponin recognition: An illustrated review

Abdorahim, Mojgan; Rabiee, Mohammad; Alhosseini, Sanaz Naghavi; Tahriri, Mohammadreza; Yazdanpanah, Sara; Alavi, S. Habib; Tayebi, Lobat

doi:10.1016/j.trac.2016.06.015

Cited by 60 publications

(34 citation statements)

References 125 publications

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“…In fact, the sensitivity and conductivity of the electrode, along with the cost of the fabricated biosensor are highly dependent on the selection of specific electrode material. Consequently, the materials selected for the fabrication of WE, RE, and CE may differ from each other depending on the target cytokine to be analyzed and the type of analysis required [68]. These electrodes can be fabricated using conducting pastes comprised of graphene, gold, silver, carbon and heavy metal.…”

Section: Surface Modification Of Electrodesmentioning

confidence: 99%

Cytokine and Cancer Biomarkers Detection: The Dawn of Electrochemical Paper-Based Biosensor

Loo

Pui

2020

Sensors

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Although the established ELISA-based sensing platforms have many benefits, the importance of cytokine and cancer biomarkers detection for point-of-care diagnostics has propelled the search for more specific, sensitive, simple, accessible, yet economical sensor. Paper-based biosensor holds promise for future in-situ applications and can provide rapid analysis and data without the need to conduct in a laboratory. Electrochemical detection plays a vital role in interpreting results obtained from qualitative assessment to quantitative determination. In this review, various factors affecting the design of an electrochemical paper-based biosensor are highlighted and discussed in depth. Different detection methods, along with the latest development in utilizing them in cytokine and cancer biomarkers detection, are reviewed. Lastly, the fabrication of portable electrochemical paper-based biosensor is ideal in deliberating positive societal implications in developing countries with limited resources and accessibility to healthcare services.

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Section: Surface Modification Of Electrodesmentioning

confidence: 99%

Cytokine and Cancer Biomarkers Detection: The Dawn of Electrochemical Paper-Based Biosensor

Loo

Pui

2020

Sensors

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“…50 Electrodes could be constructed using conducting pastes of materials such as gold, platinum, carbon, silver, graphene and heavy metal. Carbon paste is most commonly used in the fabrication of WE and CE in the screen printing technique.…”

Section: ·4 Electrodes Characterization: Fabrication and Surface Modmentioning

confidence: 99%

Trends in Paper-based Electrochemical Biosensors: From Design to Application

et al. 2018

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Electrochemical bio-sensing using paper-based detection systems is the main focus of this review. The different existing designs of 2-dimensional and 3-dimensional sensors, and fabrication techniques are discussed. This review highlights the effect of adopting different sensor designs, distinct fabrication techniques, as well as different modification methods, in order to produce reliable and reproducible reading. The use of various nanomaterials have been demonstrated in order to modify the surface of electrodes during fabrication to further enhance the signal for subsequent analysis. The reviewed sensors were classified into categories based on their applications, such as diagnostics, environmental and food testing. One of the major advantages of using paper-based electrochemical sensors is the potential for miniaturization, which only requires relatively small amount of samples, and the low cost for the purpose of mass production. Additionally, most of the devices reviewed were made to be portable, making them well-suited for on-site detection. Finally, paper-based detection is an ideal platform to fabricate cost-effective, user-friendly and sensitive electrochemical biosensors, with large capacity for customization depending on functional needs.

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“…Cardiac troponins (I and T) have been recommended as the biomarkers of choice for the serological diagnosis and prognosis of AMI because of their high sensitivity and specificity [49]. Among various methods developed for the detection of cTnI and cTnT, electrochemical sensors have been proven to be better due to their simplicity, sensitivity and rapidity [10].…”

Section: Cardiac Troponin T (Ctnt) and I (Ctni)mentioning

confidence: 99%

Nanomaterials‐based Electrochemical Sensing of Cardiac Biomarkers for Acute Myocardial Infarction: Recent Progress

Nsabimana

Yuan

et al. 2018

Electroanalysis

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The development of the methods for early and accurate diagnosis of acute myocardial infarction are needed to facilitate immediate treatment of patients. One of the ways to achieve that is the detection of cardiac biomarkers for myocardial infarction, such as thrombin, cardiac troponins (I and T), myoglobin, etc. Nanotechnology has played an important role in the development of sensitive and efficient electrochemical sensors for cardiac biomarkers. In this review, we discuss recent progress on nanomaterial‐based electrochemical sensing of various cardiac biomarkers for acute myocardial infarction.

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Nanomaterials-based electrochemical immunosensors for cardiac troponin recognition: An illustrated review

Cited by 60 publications

References 125 publications

Cytokine and Cancer Biomarkers Detection: The Dawn of Electrochemical Paper-Based Biosensor

Cytokine and Cancer Biomarkers Detection: The Dawn of Electrochemical Paper-Based Biosensor

Trends in Paper-based Electrochemical Biosensors: From Design to Application

Nanomaterials‐based Electrochemical Sensing of Cardiac Biomarkers for Acute Myocardial Infarction: Recent Progress

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