Nanomaterials, Autophagy, and Lupus Disease

Bianco, Alberto; Muller, Sylviane

doi:10.1002/cmdc.201500233

Cited by 9 publications

(5 citation statements)

References 97 publications

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“…Several nanoscale galenic forms have been developed to serve as vectors or car riers of proteins, peptides or nucleic acids, and a vast literature describes the many advantages of using such nano structures in nanomedicine. However, safety is a concern as some carbon nanostructures have been claimed to induce nanotoxicity, accompanied by the induction of autophagy and lysosomal dysfunction [329][330][331][332] (reviewed elsewhere [333][334][335][336] ).…”

Section: Challenges and Outlookmentioning

confidence: 99%

Lysosomes as a therapeutic target

Bonam

Wang

Muller

2019

Nat Rev Drug Discov

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495

374

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| Lysosomes are membrane-bound organelles with roles in processes involved in degrading and recycling cellular waste, cellular signalling and energy metabolism. Defects in genes encoding lysosomal proteins cause lysosomal storage disorders, in which enzyme replacement therapy has proved successful. Growing evidence also implicates roles for lysosomal dysfunction in more common diseases including inflammatory and autoimmune disorders, neurodegenerative diseases, cancer and metabolic disorders. With a focus on lysosomal dysfunction in autoimmune disorders and neurodegenerative diseases -including lupus, rheumatoid arthritis, multiple sclerosis, Alzheimer disease and Parkinson disease -this Review critically analyses progress and opportunities for therapeutically targeting lysosomal proteins and processes, particularly with small molecules and peptide drugs.

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Section: Challenges and Outlookmentioning

confidence: 99%

Lysosomes as a therapeutic target

Bonam

Wang

Muller

2019

Nat Rev Drug Discov

Self Cite

495

374

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“…Oxidative stress, inflammation, cell apoptosis, and other unknown mechanisms occur as a result of NM-driven toxicity [ 165 , 166 ]. Some studies have reported that autophagy can develop cancer [ 167 ], autoimmune diseases [ 168 ], and cardiovascular diseases [ 169 ]. The reported hepatotoxicity [ 170 , 171 ], nephrotoxicity [ 159 , 172 , 173 ], pulmonary toxicity [ 174 , 175 ], neurotoxicity [ 176 , 177 , 178 ], and cardiovascular toxicity [ 179 , 180 ] are concerning aspects related to the biosafety of NM applications.…”

Section: Nanomaterial-mediated Autophagy Risksmentioning

confidence: 99%

Autophagy and Biomaterials: A Brief Overview of the Impact of Autophagy in Biomaterial Applications

Pirmoradi,

Shojaei,

Ghavami

et al. 2023

Pharmaceutics

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Macroautophagy (hereafter autophagy), a tightly regulated physiological process that obliterates dysfunctional and damaged organelles and proteins, has a crucial role when biomaterials are applied for various purposes, including diagnosis, treatment, tissue engineering, and targeted drug delivery. The unparalleled physiochemical properties of nanomaterials make them a key component of medical strategies in different areas, such as osteogenesis, angiogenesis, neurodegenerative disease treatment, and cancer therapy. The application of implants and their modulatory effects on autophagy have been known in recent years. However, more studies are necessary to clarify the interactions and all the involved mechanisms. The advantages and disadvantages of nanomaterial-mediated autophagy need serious attention in both the biological and bioengineering fields. In this mini-review, the role of autophagy after biomaterial exploitation and the possible related mechanisms are explored.

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“…In addition to the widespread attention paid to the nano-therapy of cancer and neurodegenerative diseases, there have been increasing reports on the occurrence and development of immune system disorders and osteoarthropathy, which are closely related to autophagy disorders. For example, MWCNTs were able to downregulate autophagy of T and B cells to its basal level, restoring the autoimmune condition and alleviating the pathological progression of systemic lupus erythematosus (SLE) [37]. In comparison, in the treatment of rheumatoid arthritis (RA), fumagillin prodrug (Fum-PD) NPs can promote autophagic flux, followed by inhibition of the NF-κB signaling pathway-dependent inflammatory response [232].…”

Section: Other Potential Therapiesmentioning

confidence: 99%

“…Combined with the above observations, autophagy may play different roles in the biological behavior of NMs, such as the promoter, transfer station, or effect endpoint, and this regulation mode may play completely opposite roles in physiological and pathological states. Studies in recent years have shown that autophagy can lead to the development of cancer [35], neurodegenerative disease [36], autoimmune disease [37], and cardiovascular disease [38]. Therefore, how to use NMs including their composites to regulate the autophagy process has very important reference value for the effective clinical treatment of these diseases.…”

Section: Introductionmentioning

confidence: 99%

Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine

Feng

Zhang

et al. 2020

Part Fibre Toxicol

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Background Widespread biomedical applications of nanomaterials (NMs) bring about increased human exposure risk due to their unique physicochemical properties. Autophagy, which is of great importance for regulating the physiological or pathological activities of the body, has been reported to play a key role in NM-driven biological effects both in vivo and in vitro. The coexisting hazard and health benefits of NM-mediated autophagy in biomedicine are nonnegligible and require our particular concerns. Main body We collected research on the toxic effects related to NM-mediated autophagy both in vivo and in vitro. Generally, NMs can be delivered into animal models through different administration routes, or internalized by cells through different uptake pathways, exerting varying degrees of damage in tissues, organs, cells, and organelles, eventually being deposited in or excreted from the body. In addition, other biological effects of NMs, such as oxidative stress, inflammation, necroptosis, pyroptosis, and ferroptosis, have been associated with autophagy and cooperate to regulate body activities. We therefore highlight that NM-mediated autophagy serves as a double-edged sword, which could be utilized in the treatment of certain diseases related to autophagy dysfunction, such as cancer, neurodegenerative disease, and cardiovascular disease. Challenges and suggestions for further investigations of NM-mediated autophagy are proposed with the purpose to improve their biosafety evaluation and facilitate their wide application. Databases such as PubMed and Web of Science were utilized to search for relevant literature, which included all published, Epub ahead of print, in-process, and non-indexed citations. Conclusion In this review, we focus on the dual effect of NM-mediated autophagy in the biomedical field. It has become a trend to use the benefits of NM-mediated autophagy to treat clinical diseases such as cancer and neurodegenerative diseases. Understanding the regulatory mechanism of NM-mediated autophagy in biomedicine is also helpful for reducing the toxic effects of NMs as much as possible.

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Nanomaterials, Autophagy, and Lupus Disease

Cited by 9 publications

References 97 publications

Lysosomes as a therapeutic target

Lysosomes as a therapeutic target

Autophagy and Biomaterials: A Brief Overview of the Impact of Autophagy in Biomaterial Applications

Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine

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