Nanomaterials assisted chemo-photothermal therapy for combating cancer drug resistance

Patel, Vruti; Rajani, Chitra; Tambe, Vishakha; Kalyane, Dnyaneshwar; Anup, Neelima; Deb, Pran Kishore; Kalia, Kiran; Tekade, Rakesh K.

doi:10.1016/j.jddst.2022.103164

Cited by 13 publications

(6 citation statements)

References 115 publications

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“…Firstly, significant factors were screened by performing preliminary experiments. In that, factors considered for screening includes temperature (50-150°C), pH (6)(7)(8)(9)(10)(11)(12), gold concentration (150-250 μL, 1%w/v), HA amount (20-30 mg), reaction time (6-8 min), etc. Significant factors, that is, gold concentration, HA amount and reaction time, were further considered for optimization.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, photothermal ablation has emerged as a potential alternative tool for breast cancer therapy (6)(7)(8). It employs photothermal agents such as gold nanoparticles (9,10), silver nanoparticles, black phosphorous (11), carbon nanotubes (12), copper sulfide nanoparticles (13), polymeric nanoparticles (14), palladium nanoparticles (15), platinum nanoparticles (16), etc., for thermally ablating the cancer cells (17).…”

Section: Introductionmentioning

confidence: 99%

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Cancer Cell‐Specific and Laser‐Activatable NanoSeeds for Targeted Photothermal Ablation of Triple‐Negative Breast Cancer

Kalyane

Polaka

Vasdev

et al. 2022

Photochem & Photobiology

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This investigation reports the quality‐by‐design (QbD) assisted novel templated approach for developing cancer cell‐specific and laser‐activatable nanoseeds (AuraTherm) for targeted photothermal ablation of triple‐negative breast cancer (TNBC). AuraTherm was nanometric in size as characterized by SEM, TEM and particle analysis (80.28 ± 2.56 nm; −21.80 ± 0.17 mV) with hemocompatibility and neutrality towards blood components. AuraTherm showed reversible photothermal effect (ΔT: 37 ± 1.2°C → 49.4 ± 1.5°C; 15 min; 2.4 W cm−2) employing near‐infrared 808 nm laser (NIR‐808). The targeted cytosolic localization led to a significant anticancer activity as evaluated using apoptosis assay, cell cycle analysis, Intracellular ROS generation assay, cellular uptake and receptor binding assay. The NIR‐808 laser‐responsive photothermal ablation of cancer cell was found to be more effective compared to without NIR‐808 laser‐treated counterparts, suggesting the fundamental role of photothermal ablation in the treatment of TNBC.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cancer Cell‐Specific and Laser‐Activatable NanoSeeds for Targeted Photothermal Ablation of Triple‐Negative Breast Cancer

Kalyane

Polaka

Vasdev

et al. 2022

Photochem & Photobiology

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“…Physical modalities include photothermal therapy and MRI therapy (Guo et al, 2023;Makarova et al, 2022;Patel et al, 2022). Biochemical modalities include various biochemical molecules that affect cell stiffness and morphology, such as F-actin, phospholipid bilayer composition which affects cell mobility, adhesion proteins (e.g., calmodulin and integrins) that affect cell adhesion ability, and specific molecules in specific pathological situations (e.g., estrogen promotion in breast cancer) (Zbiral et al, 2021) It is worth noting that modulating cancer metastasis by altering cell or tissue mechanics requires some clear prerequisites.…”

Section: Treatment Of Cancermentioning

confidence: 99%

Atomic force microscopy in disease‐related studies: Exploring tissue and cell mechanics

Liu,

Han,

Kong

et al. 2023

Microscopy Res & Technique

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Despite significant progress in human medicine, certain diseases remain challenging to promptly diagnose and treat. Hence, the imperative lies in the development of more exhaustive criteria and tools. Tissue and cellular mechanics exhibit distinctive traits in both normal and pathological states, suggesting that “force” represents a promising and distinctive target for disease diagnosis and treatment. Atomic force microscopy (AFM) holds great promise as a prospective clinical medical device due to its capability to concurrently assess surface morphology and mechanical characteristics of biological specimens within a physiological setting. This review presents a comprehensive examination of the operational principles of AFM and diverse mechanical models, focusing on its applications in investigating tissue and cellular mechanics associated with prevalent diseases. The findings from these studies lay a solid groundwork for potential clinical implementations of AFM.Research HighlightsBy examining the surface morphology and assessing tissue and cellular mechanics of biological specimens in a physiological setting, AFM shows promise as a clinical device to diagnose and treat challenging diseases.

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“…Combination medicines can perform better than single drugs owing to the powerful synergistic effect of multimodal therapeutics. Studies have revealed that PTT and chemotherapy complement each other by enhancing drug performance in the combination form compared to individual parent drugs. ,, Most combination therapeutics involve active agents developed via costly, multiple-step, and complicated organic synthesis commonly known for a very low product yield. ,,− Thus, it is of utmost importance to implement new economical and simple synthesis strategies for the development of combination drugs.…”

Section: Introductionmentioning

confidence: 99%

Doxorubicin-Based Ionic Nanomedicines for Combined Chemo-Phototherapy of Cancer

Bashiru,

Macchi,

Forson

et al. 2024

ACS Appl. Nano Mater.

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Synergistic combination therapy approach offers lots of options for delivery of materials with anticancer properties, which is a very promising strategy to treat a variety of malignant lesions with enhanced therapeutic efficacy. The current study involves a detailed investigation of combination ionic nanomedicines where a chemotherapeutic drug is coupled with a photothermal agent to attain dual mechanisms (chemotherapy (chemo) and photothermal therapy (PTT)) to improve the drug's efficacy. An FDA-approved Doxorubicin hydrochloride (DOX• HCl) is electrostatically attached with a near-infrared cyanine dye (ICG, IR783, and IR820), which serves as a PTT drug using ionic liquid chemistry to develop three ionic material (IM)-based chemo-PTT drugs. Carrier-free ionic nanomedicines (INMs) are derived from ionic materials (IMs). The photophysical properties of the developed combination IMs and their INMs were studied in depth. The phototherapeutic efficiency of the combination drugs was evaluated by measuring the photothermal conversion efficiency and singlet-oxygen quantum yield. The improved photophysical properties of the combination nanomedicines in comparison to their parent compounds significantly enhanced INMs' photothermal efficiency. Cellular uptake, dark and light toxicity studies, and cell death mechanisms of the chemo-PTT nanoparticles were also studied in vitro. The combination INMs exhibited enhanced cytotoxicity compared to their respective parent compounds. Moreover, the apoptosis cell death mechanism was almost doubled for combination nanomedicine than the free DOX, which is attributed to enhanced cellular uptake. Examination of the combination index and improved in vitro cytotoxicity results revealed a great synergy between chemo and PTT drugs in the developed combination nanomedicines.

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Nanomaterials assisted chemo-photothermal therapy for combating cancer drug resistance

Cited by 13 publications

References 115 publications

Cancer Cell‐Specific and Laser‐Activatable NanoSeeds for Targeted Photothermal Ablation of Triple‐Negative Breast Cancer

Cancer Cell‐Specific and Laser‐Activatable NanoSeeds for Targeted Photothermal Ablation of Triple‐Negative Breast Cancer

Atomic force microscopy in disease‐related studies: Exploring tissue and cell mechanics

Doxorubicin-Based Ionic Nanomedicines for Combined Chemo-Phototherapy of Cancer

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