Nanomaterials as Enhanced Antimicrobial Agent/Activity-Enhancer for Transdermal Applications: A Review

Kale, S. N.; Kitture, Rohini; Ghosh, Sougata; Chopade, Balu A.; Yakhmi, J. V.

doi:10.1016/b978-0-323-52733-0.00011-2

Cited by 12 publications

(5 citation statements)

References 120 publications

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“…To date, CNT‐based nanomaterials have been studied for use in biomedicine, biosensors, drug delivery, tissue engineering, and wound healing applications. Functionalized CNT is known as one of the most popular nanocarriers due to its high specific surface area and it can be used for effective drug delivery 115 . In addition, CNT can kill or suppress bacteria 116 .…”

Section: Wound Dressingsmentioning

confidence: 99%

“…Functionalized CNT is known as one of the most popular nanocarriers due to its high specific surface area and it can be used for effective drug delivery. 115 In addition, CNT can kill or suppress bacteria. 116 CNT‐based dressings have been shown to increase fibroblast cells migration and proliferation and also have a significant effect on angiogenesis potential l. 117 , 118 …”

Section: Wound Dressingsmentioning

confidence: 99%

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Emerging treatment strategies in wound care

Mirhaj

Labbaf

Tavakoli

et al. 2022

International Wound Journal

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Wound healing is a complex process in tissue regeneration through which the body responds to the dissipated cells as a result of any kind of severe injury. Diabetic and non-healing wounds are considered an unmet clinical need. Currently, different strategic approaches are widely used in the treatment of acute and chronic wounds which include, but are not limited to, tissue transplantation, cell therapy and wound dressings, and the use of an instrument. A large number of literatures have been published on this topic; however, the most effective clinical treatment remains a challenge. The wound dressing involves the use of a scaffold, usually using biomaterials for the delivery of medication, autologous stem cells, or growth factors from the blood. Antibacterial and anti-inflammatory drugs are also used to stop the infection as well as accelerate wound healing. With an increase in the ageing population leading to diabetes and associated cutaneous wounds, there is a great need to improve the current treatment strategies. This research critically reviews the current advancement in the therapeutic and clinical approaches for wound healing and tissue regeneration. The results of recent clinical trials suggest that the use of modern dressings and skin substitutes is the easiest, most accessible, and most cost-effective way to treat chronic wounds with advances in materials science such as graphene as 3D scaffold and biomolecules hold significant promise. The annual market value for successful wound treatment exceeds over $50 billion US dollars, and this will encourage industries as well as academics to investigate the application of emerging smart materials for modern dressings and skin substitutes for wound therapy.cells therapy, platelet therapy, skin tissue engineering, wound dressing, wound healing Key Messages• treatment of wound healing is currently considered an unmet clinical need • currently heavily under research are growth factors and cytokines released from platelets and leukocytes that have a significant effect on the cellular functions such as migration, differentiation, and proliferation, so they can regulate the wound healing process

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Section: Wound Dressingsmentioning

confidence: 99%

Section: Wound Dressingsmentioning

confidence: 99%

Emerging treatment strategies in wound care

Mirhaj

Labbaf

Tavakoli

et al. 2022

International Wound Journal

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“…Nanomaterials have a wide range of applications in biotechnology and medicine, such as biosensors, drug delivery, tissue engineering, cancer treatment, and antimicrobial agents [30,[93][94][95][96][97][98]. Cytotoxicity studies are expected for 2DMs to be compatible with proposed biomedical applications [99].…”

Section: Cytotoxicity Studies Of Various 2d Nanomaterialsmentioning

confidence: 99%

A Review on Environmental and Economic Impact of 2D Nanomaterials‐Based Heat Transfer Fluids

Shaik

Goyal

et al. 2022

Journal of Nanomaterials

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2D nanomaterials-based heat transfer fluids show excellent thermal properties due to their large specific surface area; hence, they find large-scale applications in automobile industries and cooling processes. Therefore, it is very essential to study the environmental and economic aspects of these 2D nanomaterial-based nanofluids. In this review, we have discussed the environmental impact of 2D nanomaterial-based heat transfer nanofluids under various conditions. The environmental impact analysis of these materials has shown excellent capability in reducing the energy consumption for heat transfer operations. Moreover, the possibility of nanomaterials and base fluid recovery makes it a sustainable alternative. In addition, health risk assessment on humans, cytotoxicity, and life cycle analysis have also been explored. The price-performance index has been successfully used to study the economic impact of 2D nanomaterial-based heat transfer fluids. The overall economic impact of 2D nanomaterial-based heat transfer nanofluids provides an optimistic perspective over conventional heat transfer fluids. Moreover, graphene production, market trend, and commercialization obstacles were also discussed.

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“…Carbon nanotubes (CNTs) are one of the most preferred nanocarriers, owing to their large specific surface area that can be exploited for efficient drug adsorption, either in the tube or bonded on the surface. Rational modification of CNTs can enhance drug encapsulation efficiency and stability while reducing drug release rate and cytotoxicity [ 46 , 47 ]. Chen et al [ 48 ] reported isoniazid (INH)-loaded chitosan (CS)/carbon nanotubes microspheres with the ability to promote secondary wound healing in bone tuberculosis of guinea pigs initially infected subcutaneously with Mycobacterium tuberculosis [ 48 ].…”

Section: Application Of Different Nanomaterials In Wound Healingmentioning

confidence: 99%

Nanomaterials in Wound Healing and Infection Control

et al. 2021

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Wounds continue to be a serious medical concern due to their increasing incidence from injuries, surgery, burns and chronic diseases such as diabetes. Delays in the healing process are influenced by infectious microbes, especially when they are in the biofilm form, which leads to a persistent infection. Biofilms are well known for their increased antibiotic resistance. Therefore, the development of novel wound dressing drug formulations and materials with combined antibacterial, antibiofilm and wound healing properties are required. Nanomaterials (NM) have unique properties due to their size and very large surface area that leads to a wide range of applications. Several NMs have antimicrobial activity combined with wound regeneration features thus give them promising applicability to a variety of wound types. The idea of NM-based antibiotics has been around for a decade at least and there are many recent reviews of the use of nanomaterials as antimicrobials. However, far less attention has been given to exploring if these NMs actually improve wound healing outcomes. In this review, we present an overview of different types of nanomaterials explored specifically for wound healing properties combined with infection control.

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Nanomaterials as Enhanced Antimicrobial Agent/Activity-Enhancer for Transdermal Applications: A Review

Cited by 12 publications

References 120 publications

Emerging treatment strategies in wound care

Emerging treatment strategies in wound care

A Review on Environmental and Economic Impact of 2D Nanomaterials‐Based Heat Transfer Fluids

Nanomaterials in Wound Healing and Infection Control

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