Nanomaterials as electrochemical detectors in microfluidics and CE: Fundamentals, designs, and applications

Pumera, Martin; Escarpa, Alberto

doi:10.1002/elps.200900008

Cited by 83 publications

(71 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, electrochemical detection is capable of remarkable sensitivity with minimal power requirements. [15][16][17] Both the development of CO 2 laser treatment of polymethylmethacrylate (PMMA) (Refs. 18 and 19) and the application of these modified plastics 20,21 have been reported.…”

Section: Introductionmentioning

confidence: 99%

A parallel microfluidic channel fixture fabricated using laser ablated plastic laminates for electrochemical and chemiluminescent biodetection of DNA

Edwards

Harper²,

Polsky³

et al. 2011

Biomicrofluidics

View full text Add to dashboard Cite

Herein is described the fabrication and use of a plastic multilayer 3-channel microfluidic fixture. Multilayer devices were produced by laser machining of plastic polymethylmethacrylate and polyethyleneterapthalate laminates by ablation. The fixture consisted of an array of nine individually addressable gold or gold/ITO working electrodes, and a resistive platinum heating element. Laser machining of both the fluidic pathways in the plastic laminates, and the stencil masks used for thermal evaporation to form electrode regions on the plastic laminates, enabled rapid and inexpensive implementation of design changes. Electrochemiluminescence reactions in the fixture were achieved and monitored through ITO electrodes. Electroaddressable aryl diazonium chemistry was employed to selectively pattern gold electrodes for electrochemical multianalyte DNA detection from double stranded DNA (dsDNA) samples. Electrochemical detection of dsDNA was achieved by melting of dsDNA molecules in solution with the integrated heater, allowing detection of DNA sequences specific to breast and colorectal cancers with a non-specific binding control. Following detection, the array surface could be renewed via high temperature (95 C) stripping using the integrated heating element. This versatile and simple method for prototyping devices shows potential for further development of highly integrated, multi-functional bioanalytical devices.

show abstract

Section: Introductionmentioning

confidence: 99%

A parallel microfluidic channel fixture fabricated using laser ablated plastic laminates for electrochemical and chemiluminescent biodetection of DNA

Edwards

Harper²,

Polsky³

et al. 2011

Biomicrofluidics

View full text Add to dashboard Cite

show abstract

“…Number of reviews covering this topic has been published. For example, Pumera and Escarpa [81] summarized the different approaches for constructing nanomaterialbased detectors for conventional CE and microchip electrophoresis and mostly focused on three main types of nanomaterials, that is, carbon nanotubes, nanoparticles, and nanorods, in various designs. The work by Garcia-Carmona focusses on highlighting the electrochemical detection enhancement in CE, chip electrophoresis, and paper-based microfluidic devices [82].…”

Section: Novel Nanomaterials -Synthesis and Applicationsmentioning

confidence: 99%

Capillary Electrophoresis in Nanotechnologies versus Nanotechnologies in Capillary Electrophoresis

Adam¹,

Vaculovičová²

2018

Novel Nanomaterials - Synthesis and Applications

View full text Add to dashboard Cite

Nanomaterials are attracting an interest of many researches. All this attention is due the unique physical and chemical properties of nanomaterials differing significantly from the bulk materials mainly due to their size in range of nanometers. Capillary electrophoresis (CE) is a powerful, well-established analytical technique that provides numerous valuable benefits over other separation methods including high-performance liquid chromatography. The connection between CE and nanotechnology can be approached by two strategies: (i) CE analysis of nanomaterials and (ii) nanomaterials for CE improvement. The first perspective focuses on uses of CE as a method for characterization employed during nanomaterial production and modification as well as for monitoring their properties and interactions with other molecules. The second viewpoint deals with applications of nanomaterials for improving CE performance, mainly by enhancing efficiency of separation using nanomaterials as a stationary or pseudo-stationary phase and by enhancing detection sensitivity and/or selectivity in both optical and electrochemical detection. Moreover, applications of nanomaterials for sample preparation before CE analysis will be mentioned. This chapter aims at highlighting the symbiosis of CE and nanotechnology as a combination of modern, progressive field with well-known and reliable analytical method.

show abstract

“…Their high surface areas and electrical conductivities are quite attractive features in terms of electrochemical sensing and biosensing [1,2]. The large surface area of these carbon nanomaterial-based electrodes allows detection potentials to be decreased (thus improving the selectivity of analysis), while amperometric faradic currents are increased (leading to enhanced analytical sensitivity) and surface fouling is reduced (thereby improving reproducibility) [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Screen-printed electrodes modified with carbon nanotubes or graphene for simultaneous determination of melatonin and serotonin

et al. 2015

Self Cite

View full text Add to dashboard Cite

Single-walled carbon nanotubes (SWCNT), multiwalled carbon nanotubes (MWCNT) and graphene have been tested as carbon allotropes for the modification of carbon screen-printed electrodes (CSPEs) to simultaneously determine melatonin (MT) and serotonin (5-HT). Two groups of CSPEs, both 4 mm in diameter, were explored: The first includes commercial SWCNT, MWCNT and graphene, the second includes SWCNT, MWCNT, graphene oxide nanoribbons and reduced nanoribbons that were drop casted on the electrodes. The carbon nanomaterials enhanced the electroactive area in the following order: CSPE

show abstract

Nanomaterials as electrochemical detectors in microfluidics and CE: Fundamentals, designs, and applications

Cited by 83 publications

References 62 publications

A parallel microfluidic channel fixture fabricated using laser ablated plastic laminates for electrochemical and chemiluminescent biodetection of DNA

A parallel microfluidic channel fixture fabricated using laser ablated plastic laminates for electrochemical and chemiluminescent biodetection of DNA

Capillary Electrophoresis in Nanotechnologies versus Nanotechnologies in Capillary Electrophoresis

Screen-printed electrodes modified with carbon nanotubes or graphene for simultaneous determination of melatonin and serotonin

Contact Info

Product

Resources

About