Nanomaterials and singlet oxygen photosensitizers: potential applications in photodynamic therapy

Wang, Shizhong; Gao, Rong; Zhou, Feimeng; Selke, Matthias

doi:10.1039/b311429e

Cited by 360 publications

(225 citation statements)

References 75 publications

(83 reference statements)

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“…The latest development in PDT research is the possibility of using nanomaterials as PS carriers, and, furthermore, delivering PS together with an imaging agent via nanocarriers for selective and targeted PDT (Wang et al 2004;Josefsen and Boyle 2012).…”

Section: The Development Of Photosensitisers For Clinical Usementioning

confidence: 99%

Porphyrin-based cationic amphiphilic photosensitisers as potential anticancer, antimicrobial and immunosuppressive agents

2017

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Photodynamic therapy (PDT) combines a photosensitiser, light and molecular oxygen to induce oxidative stress that can be used to kill pathogens, cancer cells and other highly proliferative cells. There is a growing number of clinically approved photosensitisers and applications of PDT, whose main advantages include the possibility of selective targeting, localised action and stimulation of the immune responses. Further improvements and broader use of PDT could be accomplished by designing new photosensitisers with increased selectivity and bioavailability. Porphyrin-based photosensitisers with amphiphilic properties, bearing one or more positive charges, are an effective tool in PDT against cancers, microbial infections and, most recently, autoimmune skin disorders. The aim of the review is to present some of the recent examples of the applications and research that employ this specific group of photosensitisers. Furthermore, we will highlight the link between their structural characteristics and PDT efficiency, which will be helpful as guidelines for rational design and evaluation of new PSs.

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Section: The Development Of Photosensitisers For Clinical Usementioning

confidence: 99%

Porphyrin-based cationic amphiphilic photosensitisers as potential anticancer, antimicrobial and immunosuppressive agents

2017

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“…1 O 2 is a strong oxidant with standard reduction potential of E h = 1.52 V [22]. It is usually produced by photocatalytic activation of dissolved oxygen on metal oxides such as TiO 2 and ZnO [23,24]. In addition, many other chemicals such as potassium perchromate [25], triphenyl phosphite [26] and ozonide [27] could also generate 1 O 2 .…”

Section: Introductionmentioning

confidence: 99%

Cyanide oxidation by singlet oxygen generated via reaction between H 2 O 2 from cathodic reduction and OCl − from anodic oxidation

Tian¹,

Zeng

et al. 2016

Journal of Colloid and Interface Science

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“…Moreover, some nanomaterials can generate singlet oxygen. 8,9 Although this area has not received as much attention as the application of nanomaterials to electronics or catalysis, it represents a promising route to overcoming many We report herein the preparation of water-soluble QDs, using Meso-Tetra (4-sulfonatophenyl) Porphine Dihydrochloride (TSPP) as a photosensitizer, bound to CdTe nanocrystals via electrostatic interactions. The advantage of the electrostatic approach used in our work is that it allows control over the assembly behavior in solution.…”

Section: Introductionmentioning

confidence: 99%

Singlet Oxygen Generation from Water-Soluble Quantum Dot−Organic Dye Nanocomposites

2006

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Water-soluble quantum dot -organic dye nanocomposites have been prepared via electrostatic interaction. We used CdTe quantum dots with diameters up to 3.4 nm, 2-aminoethanthiol as a stabilizer, and meso-tetra (4-sulfonatophenyl) porphine dihydrochloride (TSPP) as an organic dye. The photophysical properties of the nanocomposite have been investigated. The fluorescence of the parent CdTe quantum dot is largely suppressed. Instead, indirect excitation of the TSPP moiety leads to production of singlet oxygen with a quantum yield of 0.43. The nanocomposite is sufficiently photostable for biological applications.Colloidal semiconductor nanocrystals (Quantum Dots, QDs) can provide three-dimensional (3D) architectures and have attracted widespread interest, since their nano-size physical properties are quite different from those of bulk materials. 1 QDs photoluminescence can be size-tuned to improve spectral overlap with a particular acceptor, and having several acceptors interact with a single QDs donor substantially improves fluorescence resonance energy transfer (FRET) efficiency. Retaining the small probe size is critical for successful in vivo applications since large-sized probes significantly reduce biostability, diffusion, and circulation processes, and increase undesired nonspecific binding. 2 The small size of QDs is valuable for enhancing biological targeting efficiency and specificity. 3 Photodynamic therapy (PDT) is an emerging modality for the treatment of a variety of oncological, dermatological, and other types of cancer. 4 Singlet oxygen ( 1 O 2 ) is believed to be a major cyctotoxic species in this process. There have been several reports of nanoparticles as carriers for singlet oxygen photosensitizers. 5-7 Nanoparticles can be ideal carriers of photosensitizer molecules for PDT. Moreover, some nanomaterials can generate singlet oxygen. 8,9 Although this area has not received as much attention as the application of nanomaterials to electronics or catalysis, it represents a promising route to overcoming many We report herein the preparation of water-soluble QDs, using Meso-Tetra (4-sulfonatophenyl) Porphine Dihydrochloride (TSPP) as a photosensitizer, bound to CdTe nanocrystals via electrostatic interactions. The advantage of the electrostatic approach used in our work is that it allows control over the assembly behavior in solution. 14 The CdTe QDs were synthesized with 2-aminoethanethiol as surface stabilizer. Synthesis of yellow photofluorescence CdTe nanocrystal was performed via a modified protocol adopted from the literature. 15 The CdTe QDs revealed size-dependent luminescence with maxima at 560 nm. In a typical assay, the UV-vis spectra of QD-TSPP nanocomposites shifted slightly to the blue region,compared with free TSPP (Figure 1a). This could be surface caused by surface plasma changes as TSPP deposited on the of the QDs aggregates. 16 The UV-vis peak of CdTe-TSPP nanocomposites increased with the concentration of added TSPP.Immediate aggregation was observed when the concentration of...

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Nanomaterials and singlet oxygen photosensitizers: potential applications in photodynamic therapy

Cited by 360 publications

References 75 publications

Porphyrin-based cationic amphiphilic photosensitisers as potential anticancer, antimicrobial and immunosuppressive agents

Porphyrin-based cationic amphiphilic photosensitisers as potential anticancer, antimicrobial and immunosuppressive agents

Cyanide oxidation by singlet oxygen generated via reaction between H 2 O 2 from cathodic reduction and OCl − from anodic oxidation

Singlet Oxygen Generation from Water-Soluble Quantum Dot−Organic Dye Nanocomposites

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