Nanomaterial-induced ferroptosis for cancer specific therapy

Liu, Mei; Liu, Bin; Liu, Qianqian; Du, Keke; Wang, Zhifei; He, Nongyue

doi:10.1016/j.ccr.2018.12.015

Cited by 135 publications

(78 citation statements)

References 162 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These discoveries pave the way for nanoparticle‐triggered ferroptosis. In recent years, ferroptosis mechanism has been taken into consideration for nanomedicine‐mediated cancer therapy, exemplified by the rapid development of nano ferroptosis inducers …”

Section: Ferroptosis Inducers For Cancer Therapymentioning

confidence: 99%

Recent Progress in Ferroptosis Inducers for Cancer Therapy

et al. 2019

View full text Add to dashboard Cite

Ferroptosis is a newly discovered form of regulated cell death that is the nexus between metabolism, redox biology, and human health. Emerging evidence shows the potential of triggering ferroptosis for cancer therapy, particularly for eradicating aggressive malignancies that are resistant to traditional therapies. Recently, there has been a great deal of effort to design and develop anticancer drugs based on ferroptosis induction. Recent advances of ferroptosis‐inducing agents at the intersection of chemistry, materials science, and cancer biology are presented. The basis of ferroptosis is summarized first to highlight the feasibility and characteristics of triggering ferroptosis for cancer therapy. A literature review of ferroptosis inducers (including small molecules and nanomaterials) is then presented to delineate their design, action mechanisms, and anticancer applications. Finally, some considerations for research on ferroptosis inducers are spotlighted, followed by a discussion on the challenges and future development directions of this burgeoning field.

show abstract

Section: Ferroptosis Inducers For Cancer Therapymentioning

confidence: 99%

Recent Progress in Ferroptosis Inducers for Cancer Therapy

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Therefore, when GSH is consumed by the cells, GPX4 activity is inhibited and the level of lipid oxidation in cells increases accordingly, which leads to ferroptosis. [ 10–14 ] However, due to their rapid growth and proliferation of tumor cells, GSH is maintained at relatively high levels to maintain the intracellular redox balance. [ 15,16 ] So far, the strategy of ferroptosis induction by inhibition of GPX4 activity has garnered considerable attention.…”

Section: Introductionmentioning

confidence: 99%

Redox Responsive Metal Organic Framework Nanoparticles Induces Ferroptosis for Cancer Therapy

Guo

et al. 2020

Small

133

View full text Add to dashboard Cite

Ferroptosis is attracting significant attention due to its effectiveness in tumor treatment. The efficiency to produce toxic lipid peroxides (LPOs) at the tumor site plays a key role in ferroptosis. A hybrid PFP@Fe/Cu‐SS metal organic framework (MOF) is synthesized and shown to increase intratumoral LPO content through redox reactions generating ·OH. In addition, glutathione (GSH) depletion through disulfide‐thiol exchange leads to the inactivation of glutathione peroxide 4 (GPX4), which results in a further increase in LPO content. This MOF exhibits high inhibitory effect on the growth of xenografted Huh‐7 tumors in mice. The coadministration of a ferroptosis inhibitor reduces the antitumor effect of the MOF, leading to a restoration of GPX4 activity and an increase in tumor growth. Moreover, the construction of Cu into mesoporous PFP@Fe/Cu‐SS not only allows the MOF to be used as a contrast agent for T1‐weighted magnetic resonance imaging, but also renders its photothermal conversion capacity. Thus, near‐infrared irradiation is able to induce photothermal therapy and transform the encapsulated liquid perfluoropentane into microbubbles for ultrasound imaging.

show abstract

“…The TME is highly complex, with hypoxic conditions owing to lower oxygen supply, pH imbalance, and GSH overproduction, as well as the expression of inhibitory proteins, which suppress traditional chemotherapeutic drug efficacy inside the cells, introducing the MDR effect. CDT, an enhanced therapeutic technique involving the generation of hydroxyl radicals (•OH) via the Fenton reaction and Fenton-like reactions, can cause lipid peroxidation, DNA damage, and apoptosis (Liu et al, 2019a ). During CDT, metal nanoparticles catalyze H 2 O 2 to generate hydroxyl radicals (•OH) and molecular oxygen.…”

Section: Application Of Stimuli-triggered Metallic Nanotherapeutics Imentioning

confidence: 99%

“…During CDT, metal nanoparticles catalyze H 2 O 2 to generate hydroxyl radicals (•OH) and molecular oxygen. The main advantages of CDT include GSH depletion and reduced hypoxic conditions in the TME, which are deemed the main source of the MDR effect (Liu et al, 2019a ). CDT is based on hydroxyl radical (•OH) generation via an iron oxide-induced Fenton reaction, as well as Fenton-like reactions induced by other metallic nanotherapeutics (CuNPs, MnO2, and GNPs) (Wang et al, 2020c ).…”

Section: Application Of Stimuli-triggered Metallic Nanotherapeutics Imentioning

confidence: 99%

External and Internal Stimuli-Responsive Metallic Nanotherapeutics for Enhanced Anticancer Therapy

Mohapatra

Uthaman

Park

2021

Front. Mol. Biosci.

View full text Add to dashboard Cite

Therapeutic, diagnostic, and imaging approaches based on nanotechnology offer distinct advantages in cancer treatment. Various nanotherapeutics have been presented as potential alternatives to traditional anticancer therapies such as chemotherapy, radiotherapy, and surgical intervention. Notably, the advantage of nanotherapeutics is mainly attributable to their accumulation and targeting ability toward cancer cells, multiple drug-carrying abilities, combined therapies, and imaging approaches. To date, numerous nanoparticle formulations have been developed for anticancer therapy and among them, metallic nanotherapeutics reportedly demonstrate promising cancer therapeutic and diagnostic efficiencies owing to their dense surface functionalization ability, uniform size distribution, and shape-dependent optical responses, easy and cost-effective synthesis procedure, and multiple anti-cancer effects. Metallic nanotherapeutics can remodel the tumor microenvironment by changing unfavorable therapeutic conditions into therapeutically accessible ones with the help of different stimuli, including light, heat, ultrasound, an alternative magnetic field, redox, and reactive oxygen species. The combination of metallic nanotherapeutics with both external and internal stimuli can be used to trigger the on-demand release of therapeutic molecules, augmenting the therapeutic efficacies of anticancer therapies such as photothermal therapy, photodynamic therapy, magnetic hyperthermia, sonodynamic therapy, chemodynamic therapy, and immunotherapy. In this review, we have summarized the role of different metallic nanotherapeutics in anti-cancer therapy, as well as their combinational effects with multiple stimuli for enhanced anticancer therapy.

show abstract

Nanomaterial-induced ferroptosis for cancer specific therapy

Cited by 135 publications

References 162 publications

Recent Progress in Ferroptosis Inducers for Cancer Therapy

Recent Progress in Ferroptosis Inducers for Cancer Therapy

Redox Responsive Metal Organic Framework Nanoparticles Induces Ferroptosis for Cancer Therapy

External and Internal Stimuli-Responsive Metallic Nanotherapeutics for Enhanced Anticancer Therapy

Contact Info

Product

Resources

About