Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections

Makabenta, Jessa Marie; Nabawy, Ahmed; Li, Cheng Hsuan; Schmidt-Malan, Suzannah M.; Patel, Robin; Rotello, Vincent M.

doi:10.1038/s41579-020-0420-1

Cited by 791 publications

(656 citation statements)

References 160 publications

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“…MO particles themselves have showed antimicrobial activity against microorganisms [22,35]. In the present study, spherical or cuboidal MgO particles presented lower antimicrobial activity against E. coli than ZnO, Cu 2 O, and CuO particles (Figure 3).…”

Section: Discussionsupporting

confidence: 45%

“…Antibiotic properties of MO particles have been mainly affected by physicochemical characteristics including morphology and particle size [1,21]. MO NPs are generally described as nano-antibiotics to combat multidrug resistance in pathogenic microorganisms [22], where antimicrobial activity is superior than that of MO MPs in most reports of antimicrobial activity tests. However, in some cases, MO MPs also showed strong antimicrobial activity based on their structural properties or combinations with other materials such as polymers and metallic compounds [23,24].…”

Section: Discussionmentioning

confidence: 99%

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Multiscale Metal Oxide Particles to Enhance Photocatalytic Antimicrobial Activity against Escherichia coli and M13 Bacteriophage under Dual Ultraviolet Irradiation

Jin

2021

Pharmaceutics

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Antimicrobial activity of multiscale metal oxide (MO) particles against Escherichia coli (E. coli) and M13 bacteriophage (phage) was investigated under dual ultraviolet (UV) irradiation. Zinc oxide (ZnO), magnesium oxide (MgO), cuprous oxide (Cu2O), and cupric oxide (CuO) were selected as photocatalytic antimicrobials in MO particles. Physicochemical properties including morphology, particle size/particle size distribution, atomic composition, crystallinity, and porosity were evaluated. Under UV-A and UV-C irradiation with differential UV-C intensities, the antimicrobial activity of MO particles was monitored in E. coli and phage. MO particles had nano-, micro- and nano- to microscale sizes with irregular shapes, composed of atoms as ratios of chemical formulae and presented crystallinity as pure materials. They had wide-range specific surface area levels of 0.40–46.34 m2/g. MO particles themselves showed antibacterial activity against E. coli, which was the highest among the ZnO particles. However, no viral inactivation by MO particles occurred in phage. Under dual UV irradiation, multiscale ZnO and CuO particles had superior antimicrobial activities against E. coli and phage, as mixtures of nano- and microparticles for enhanced photocatalytic antimicrobials. The results showed that the dual UV-multiscale MO particle hybrids exhibit enhanced antibiotic potentials. It can also be applied as a next-generation antibiotic tool in industrial and clinical fields.

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Section: Discussionsupporting

confidence: 45%

Section: Discussionmentioning

confidence: 99%

Multiscale Metal Oxide Particles to Enhance Photocatalytic Antimicrobial Activity against Escherichia coli and M13 Bacteriophage under Dual Ultraviolet Irradiation

Jin

2021

Pharmaceutics

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“…The fraction of persister cells in biofilms is usually low (~0.01%), and they should be distinguished from the metabolically inactive bacteria, which constitute a large fraction of the biofilm 49 . Nanotechnology approaches for treatment of biofilm-associated infections fall into two categories, antibiotic loaded nano-systems 50 and nano-systems for disassembling bacterial extracellular matrix 51 . The goal of the former strategy is to improve the bioavailability of conventional antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Gold nanoclusters augment a fluoroquinolone lethality against biofilm associated persister cells

Bekale

Maria

Cao

et al. 2020

Preprint

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Persister cells are an important medical concern, leading to the overuse of antibiotics and ultimately contributing to antimicrobial resistance. The use of an adjuvant that augments the antibiotic efficacy has yet to be explored for combating persister cells within biofilm infections. Here we demonstrate a paradigm shift in targeting bacteria in chronic infections by coadministration of a conventional antibiotic with a novel engineered gold nanocluster (AuNC@CPP). AuNC@CPP was found to reduce the minimum biofilm eradication concentration (MBEC) of ofloxacin up to 300-fold (from > 3000 μg/mL to 10 μg/mL). Compared to ofloxacin alone (FLOXIN®Otic), coadministration of ofloxacin with AuNC@CPP induces up to a 10,000-fold reduction in bacterial burden in a validated mouse model of chronic P. aeruginosa of ear infection mimicking chronic suppurative otitis media. The biocompatibility of AuNC@CPP encourages efforts for development as an antibiotic adjunct for combating bacterial biofilm infections.

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“…Consequently, it is urgent to develop alternative antibacterial ways for the treatment of drug-resistant bacterial infections. [5][6][7][8][9][10][11][12] Saturated fatty acids are a class of promising biomaterials due to their low cost, biocompatibility, and biodegradability. 13,14 Among them, lauric acid (LA), a medium-chain fatty acid commonly found in coconut palm and milk, is reported to have selective bactericidal activity against Gram-positive bacteria by exerting a membrane-damaging effect.…”

Section: Introductionmentioning

confidence: 99%

An Exceptional Broad-Spectrum Nanobiocide for Multimodal and Synergistic Inactivation of Drug-Resistant Bacteria

et al. 2022

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Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections

Cited by 791 publications

References 160 publications

Multiscale Metal Oxide Particles to Enhance Photocatalytic Antimicrobial Activity against Escherichia coli and M13 Bacteriophage under Dual Ultraviolet Irradiation

Multiscale Metal Oxide Particles to Enhance Photocatalytic Antimicrobial Activity against Escherichia coli and M13 Bacteriophage under Dual Ultraviolet Irradiation

Gold nanoclusters augment a fluoroquinolone lethality against biofilm associated persister cells

An Exceptional Broad-Spectrum Nanobiocide for Multimodal and Synergistic Inactivation of Drug-Resistant Bacteria

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