Nanomaterial based analytical methods for breast cancer biomarker detection

Li, Xiaoqing; Ma, Fanghui; Yang, Minghui; Zhang, Jianglin

doi:10.1016/j.mtadv.2022.100219

Cited by 15 publications

(8 citation statements)

References 174 publications

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“…Electrochemical biosensors rely on biological recognition elements and offer lower detection limits and high sensitivity and selectivity toward target analytes. The basic principle of biosensors of this kind is that the recognition between immobilized biomolecules and target analytes leads to changes in the electrical properties of the sensing material or solution, such as its conductance, potential, electric current, and ionic strength, which can be detected by amperometry, potentiometry, voltammetry, and impedance techniques [ 75 , 76 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Roles of MXenes in biomedical applications: recent developments and prospects

Fan

Zou

et al. 2023

J Nanobiotechnol

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Abstract....With the development of nanomedical technology, the application of various novel nanomaterials in the biomedical field has been greatly developed in recent years. MXenes, which are new inorganic nanomaterials with ultrathin atomic thickness, consist of layered transition metal carbides and nitrides or carbonitrides and have the general structural formula Mn+1XnTx (n = 1–3). Based on the unique structural features of MXenes, such as ultrathin atomic thickness and high specific surface area, and their excellent physicochemical properties, such as high photothermal conversion efficiency and antibacterial properties, MXenes have been widely applied in the biomedical field. This review systematically summarizes the application of MXene-based materials in biomedicine. The first section is a brief summary of their synthesis methods and surface modification strategies, which is followed by a focused overview and analysis of MXenes applications in biosensors, diagnosis, therapy, antibacterial agents, and implants, among other areas. We also review two popular research areas: wearable devices and immunotherapy. Finally, the difficulties and research progress in the clinical translation of MXene-based materials in biomedical applications are briefly discussed. Graphical Abstract

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Section: Biomedical Applicationsmentioning

confidence: 99%

Roles of MXenes in biomedical applications: recent developments and prospects

Fan

Zou

et al. 2023

J Nanobiotechnol

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“…At this point, various types of biosensors have been developed for the determination of cancer biomarkers. Many researchers have enhanced the sensitivity of biosensors by integrating nanomaterials into biosensing assays [ 84 , 85 ]. Novel chemical, physical, optical, and electrical properties of different nanomaterials and their large specific surface areas can significantly improve the ability of biosensors to detect biomarkers.…”

Section: Biosensors For Detection Of Biomarkersmentioning

confidence: 99%

“…Novel chemical, physical, optical, and electrical properties of different nanomaterials and their large specific surface areas can significantly improve the ability of biosensors to detect biomarkers. In addition, it is proved that the detection of multiple biomarkers can remarkably advance the specificity of a biosensor for the diagnosis of early-stage cancer [ 85 , 86 ].…”

Section: Biosensors For Detection Of Biomarkersmentioning

confidence: 99%

Biomarkers and Corresponding Biosensors for Childhood Cancer Diagnostics

Gharehzadehshirazi

Zarejousheghani

Falahi

et al. 2023

Sensors

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Although tremendous progress has been made in treating childhood cancer, it is still one of the leading causes of death in children worldwide. Because cancer symptoms overlap with those of other diseases, it is difficult to predict a tumor early enough, which causes cancers in children to be more aggressive and progress more rapidly than in adults. Therefore, early and accurate detection methods are urgently needed to effectively treat children with cancer therapy. Identification and detection of cancer biomarkers serve as non-invasive tools for early cancer screening, prevention, and treatment. Biosensors have emerged as a potential technology for rapid, sensitive, and cost-effective biomarker detection and monitoring. In this review, we provide an overview of important biomarkers for several common childhood cancers. Accordingly, we have enumerated the developed biosensors for early detection of pediatric cancer or related biomarkers. This review offers a restructured platform for ongoing research in pediatric cancer diagnostics that can contribute to the development of rapid biosensing techniques for early-stage diagnosis, monitoring, and treatment of children with cancer and reduce the mortality rate.

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“…According to the American Cancer CA’s 2020 Global Cancer Statistics, a leading international journal, breast cancer accounts for about 2.3 million new cases, 11.7% of all cancer cases, and 685,000 deaths. It has now overtaken lung cancer as the top cancer in the category. − Early detection of breast cancer for diagnosis and treatment prior to metastasis is an important measure to improve the prognosis and reduce the risk of breast cancer recurrence and metastasis, thereby reducing breast cancer mortality. − …”

Section: Introductionmentioning

confidence: 99%

Microswimmer-Based Ultrasensitive Dual-Signal Ratiometric Electrochemical Homogeneous Aptasensor with Functionalized Co-UiO-66 for the Single-Step Detection of HER2 in Whole Blood

Zhang

et al. 2023

Anal. Chem.

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The ability to efficiently detect trace disease biomarkers in whole blood remains an enormous challenge.Researchers have paid more attention to the homogeneous electrochemical ratio biosensor due to its self-calibration capability and improved detection accuracy. However, proportional homogeneous electrochemical sensing is difficult to achieve and typically requires functional modification of the electrode or the preparation of complex materials. Herein, a dual-signal ratiometric aptamer homogeneous electrochemical microswimming detection device with active capture capability and one-step detection of human epidermal growth factor receptor-2 (HER2) is proposed. The homogeneous electrochemical biosensor is fabricated based on a functionalized nanocomposite double-stranded DNA({singlestranded DNA-ferrocene (Fc)-aptamer})@Co-UiO-66 with catalase properties and adsorptive properties to electroactive toluidine blue (TB) molecules. Encapsulation of Co-UiO-66 material with dsDNA (ssDNA-Fc-Apt) containing HER2 aptamer as a gate switch inhibited its ability to adsorb TB molecules. This functionalized Co-UiO-66 material can catalyze hydrogen peroxide. Using hydrogen peroxide as a fuel, it breaks down to release oxygen bubbles, creating a propulsion force that drives dsDNA(ssDNA-Fc-Apt)@Co-UiO-66 target HER2 through whole blood. When the surface dsDNA (ssDNA-Fc-Apt)@Co-UiO-66 recognizes HER2, a strand displacement reaction occurs, and the ssDNA-Fc is released into solution. The HER2 aptamer is coiled because it targets HER2, and the ability to adsorb TB molecules is restored due to the exposed surface of Co-UiO-66. A certain negative voltage is applied to the ITO electrode, and due to the electrostatic attraction, the TB molecules and ssDNA-Fc are adsorbed and enriched on the surface of the electrode by electrostatic attraction, which produces two strong and oppositely changing electrochemical signals, and the electrochemical signals depend on the HER2 concentration. It can sensitively detect HER2 biomarkers in only 40 min with the detection range of 0.0001−10 ng/mL and detection limits as low as 10 fg/mL. The electrochemical microswimmer for the detection of trace disease biomarkers involves a one-step process of capture, signal change, and detection.

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Nanomaterial based analytical methods for breast cancer biomarker detection

Cited by 15 publications

References 174 publications

Roles of MXenes in biomedical applications: recent developments and prospects

Roles of MXenes in biomedical applications: recent developments and prospects

Biomarkers and Corresponding Biosensors for Childhood Cancer Diagnostics

Microswimmer-Based Ultrasensitive Dual-Signal Ratiometric Electrochemical Homogeneous Aptasensor with Functionalized Co-UiO-66 for the Single-Step Detection of HER2 in Whole Blood

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