Nanomaterial applications for neurological diseases and central nervous system injury

Huang, Lijie; Hu, Jiangnan; Huang, Shuigen; Wang, Brian; Siaw-Debrah, Felix; Nyanzu, Mark; Zhang, Yu; Zhuge, Qichuan

doi:10.1016/j.pneurobio.2017.07.003

Cited by 50 publications

(30 citation statements)

References 243 publications

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“…In addition, different shapes (spherical, discoid, cylindrical, and star‐shaped) and sizes can directly influence synthesized nano‐objects behavior (Feugang, ; Jacobs & Vemuri, ; Wolfbeis, ). To date, a variety of nanosized platforms, such as liposomes, micelles, polymeric nanoparticles (NPs), and carbon nanotubes, have been used for medical purposes, especially for treatment and diagnosis of neurological diseases and cancer (Huang et al, ; Sengupta, ; Wang, Yu, Kong, & Sun, ). Frequently, nanoparticles, which are nano‐objects with all three external dimensions in the nanoscale range and of similar length (ISO, ), are based on a central core surrounded by a protective shell and an organic coating layer (i.e., polymers and peptides) that allows surface functionalization with biomolecules for the desired application (Feugang, ).…”

Section: Nanotechnologymentioning

confidence: 99%

Applications of omics and nanotechnology to improve pig embryo production in vitro

Lucas

Chen

Seixas

et al. 2019

Molecular Reproduction Devel

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An appropriate environment to optimize porcine preimplantation embryo production in vitro is required as genetically modified pigs have become indispensable for biomedical research and agriculture. To provide suitable culture conditions, omics technologies have been applied to elucidate which metabolic substrates and pathways are involved during early developmental processes. Metabolomic profiling and transcriptional analysis comparing in vivo‐ and in vitro‐derived embryos have demonstrated the important role of amino acids during preimplantation development. Transcriptional profiling studies have been helpful in assessing epigenetic reprogramming agents to allow for the correction of gene expression during the cloning process. Along with this, nanotechnology, which is a highly promising field, has allowed for the use of engineered nanoplatforms in reproductive biology. A growing number of studies have explored the use of nanoengineered materials for sorting, labeling, and targeting purposes; which demonstrates their potential to become one of the solutions for precise delivery of molecules into gametes and embryos. Considering the contributions of omics and the recent progress in nanoscience, in this review, we focused on their emerging applications for current in vitro pig embryo production systems to optimize the generation of genetically modified animals.

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Section: Nanotechnologymentioning

confidence: 99%

Applications of omics and nanotechnology to improve pig embryo production in vitro

Lucas

Chen

Seixas

et al. 2019

Molecular Reproduction Devel

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“…cerium oxide, titanium oxide, iron oxide, and zinc oxide) materials. In this cutting-edge century, fabrication of these nanoparticles (NPs), one by one or cluster, with desired particle size and shapes led to many promising applications in drug-gene delivery, disease management, pharmaceuticals, cosmetics, food, photonic crystals, coatings, paints, catalysis, bioremediation, material science, plant growth, and/or their production and protection [ 1 – 12 ].…”

Section: Reviewmentioning

confidence: 99%

Recent Status of Nanomaterial Fabrication and Their Potential Applications in Neurological Disease Management

et al. 2018

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Nanomaterials (NMs) are receiving remarkable attention due to their unique properties and structure. They vary from atoms and molecules along with those of bulk materials. They can be engineered to act as drug delivery vehicles to cross blood-brain barriers (BBBs) and utilized with better efficacy and safety to deliver specific molecules into targeted cells as compared to conventional system for neurological disorders. Depending on their properties, various metal chelators, gold nanoparticles (NPs), micelles, quantum dots, polymeric NPs, liposomes, solid lipid NPs, microparticles, carbon nanotubes, and fullerenes have been utilized for various purposes including the improvement of drug delivery system, treatment response assessment, diagnosis at early stage, and management of neurological disorder by using neuro-engineering. BBB regulates micro- and macromolecule penetration/movement, thus protecting it from many kinds of illness. This phenomenon also prevents drug delivery for the neurological disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis, amyotrophic lateral sclerosis, and primary brain tumors. For some neurological disorders (AD and PD), the environmental pollution was considered as a major cause, as observed that metal and/or metal oxide from different sources are inhaled and get deposited in the lungs/brain. Old age, obesity, diabetes, and cardiovascular disease are other factors for rapid deterioration of human health and onset of AD. In addition, gene mutations have also been examined to cause the early onset familial forms of AD. AD leads to cognitive impairment and plaque deposits in the brain leading to neuronal cell death. Based on these facts and considerations, this review elucidates the importance of frequently used metal chelators, NMs and/or NPs. The present review also discusses the current status and future challenges in terms of their application in drug delivery for neurological disease management.

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“…Nanotechnology has led to several promising results with its applications in the diagnosis and treatment of cancer, including drug delivery 2 , gene therapy, detection and diagnosis, drug carriage, biomarker mapping, targeted therapy, and molecular imaging. Nanotechnology has been applied in the development of nanomaterials 3 , such as gold nanoparticles and quantum dots, which are used for cancer diagnosis at the molecular level. Molecular diagnostics based on nanotechnology, such as the development of biomarkers, can accurately and quickly detect the cancers 4 .…”

Section: Introductionmentioning

confidence: 99%

Application of Nanotechnology in Cancer Diagnosis and Therapy - A Mini-Review

Jin¹,

Wang²,

Oppong-Gyebi³

et al. 2020

Int. J. Med. Sci.

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203

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Cancer is a leading cause of death and poor quality of life globally. Even though several strategies are devised to reduce deaths, reduce chronic pain and improve the quality of life, there remains a shortfall in the adequacies of these cancer therapies. Among the cardinal steps towards ensuring optimal cancer treatment are early detection of cancer cells and drug application with high specificity to reduce toxicities. Due to increased systemic toxicities and refractoriness with conventional cancer diagnostic and therapeutic tools, other strategies including nanotechnology are being employed to improve diagnosis and mitigate disease severity. Over the years, immunotherapeutic agents based on nanotechnology have been used for several cancer types to reduce the invasiveness of cancerous cells while sparing healthy cells at the target site. Nanomaterials including carbon nanotubes, polymeric micelles and liposomes have been used in cancer drug design where they have shown considerable pharmacokinetic and pharmacodynamic benefits in cancer diagnosis and treatment. In this review, we outline the commonly used nanomaterials which are employed in cancer diagnosis and therapy. We have highlighted the suitability of these nanomaterials for cancer management based on their physicochemical and biological properties. We further reviewed the challenges that are associated with the various nanomaterials which limit their uses and hamper their translatability into the clinical setting in certain cancer types.

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Nanomaterial applications for neurological diseases and central nervous system injury

Cited by 50 publications

References 243 publications

Applications of omics and nanotechnology to improve pig embryo production in vitro

Applications of omics and nanotechnology to improve pig embryo production in vitro

Recent Status of Nanomaterial Fabrication and Their Potential Applications in Neurological Disease Management

Application of Nanotechnology in Cancer Diagnosis and Therapy - A Mini-Review

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