Nanomanipulation in Biomedical Applications

Abstract

Purpose of Review Progress in nanorobotics over the past decades has dramatically extended our ability to explore the world down to individual molecules/atoms. As an enabling technology, nanorobotic manipulation provides the capability to the control of position and orientation of an object. This paper overviews the state-of-the-art of the advancements of nanomanipulation and focuses on its application in biomedicine. Recent Findings As the literature is showing, recent progresses on nanomanipulation have mainly been enabled by such supporting techniques as super-resolution imaging and local magnetic/plasmonic actuation, and focused on the exploration of molecular properties on an individual non-statistical basis, which includes the characterization of mechanical properties, conformational transitions, position/posture adjustment, intra-/intermolecular interactions of bio-objects, and so on. Summary Following a review focusing on recent advances in applications of nanomanipulation based on various platforms and processes (including both probe and field-based approaches) into biomedicine, future perspectives and potential trends are discussed.

Experimental extraction of Young's modulus of gastric tissue with development of spherical, cylindrical, and crowned rollers contact theories

“…Hou et al Reviewed recent advances in nanomanipulation and its applications in medicine. These improvements include mechanical properties, structural transfer, position/state regulation, intramolecular/intermolecular interactions of biological objects [ 21 ]. Korayem and Khaksar have studied the spherical and elliptical geometries of nanoparticles during manipulation.…”

Frictional behavior of one-dimensional materials: an experimental perspective

“…These materials unlock tremendous potential across a wide array of applications, ranging from the micro/nanoelectromechanical systems (MEMS/NEMS) design 14–17 to the development of nanogenerators for energy harvesting, 18–25 and advanced material innovation 26,27 to groundbreaking advancements in biomedical research. 28–34 It is vital to underscore that the design, manufacturing, and utilization of these devices are intricately linked to a deep understanding of their surface frictional behavior, as it profoundly influences their performance across various domains.…”

“…and advanced material innovation 26,27 to groundbreaking advancements in biomedical research. [28][29][30][31][32][33][34] It is vital to underscore that the design, manufacturing, and utilization of these devices are intricately linked to a deep understanding of their surface frictional behavior, as it profoundly inuences their performance across various domains.…”

In Situ Device‐Level TEM Characterization Based on Ultra‐Flexible Multilayer MoS2 Micro‐Cantilever

“…Profiting from its unique advantages of ultra-high vacuum environment (up to 10 −6 Pa), atomic level spatial resolution (up to picometer scale), [1,2] ultra-fast imaging time resolution (up to picosecond), [3] and unprecedented energy resolution (up to 0.01 eV), [4] transmission electron microscopy (TEM) has become an indispensable characterization technology to offer the abundant static atom-level material intrinsic attributes, including crystal structure, [5] electronic topology, [6] magnetic domain morphology, [7] chemical composition, [8] and structural biological information. [9] On the other hand, nanorobotic manipulation provided the capability of sub-nanometer positioning/deformation, pico-Newton-level force exertion/measurement, electromechanical engineering of functional elements, and robotic assembly for device prototyping.…”

“…[ 9 ] On the other hand, nanorobotic manipulation provided the capability of sub‐nanometer positioning/deformation, pico‐Newton‐level force exertion/measurement, electromechanical engineering of functional elements, and robotic assembly for device prototyping. [ 2,10 ] Together with the intervention of external physical fields (including mechanical, [ 10‐12 ] electrical, [ 13 ] electromechanical, [ 12 ] thermal, [ 14 ] optical, [ 15 ] magnetic fields, [ 16 ] and liquid [ 17 ] /gas [ 18 ] environment), broader in situ investigations of the dynamic behaviors of specimens have been enabled at atom‐level dynamic material intrinsic attributes (such as ion migration, [ 19 ] dislocation evolution, [ 19,20 ] phase transition, [ 21 ] mechanical stress transformation, [ 22 ] and interlayer sliding [ 23 ] ).…”