Nanomagnetite-supported molybdenum oxide (nanocat-Fe-Mo): an efficient green catalyst for multicomponent synthesis of amidoalkyl naphthols

Bankar, Swapnil R.; Shelke, Sharad N.

doi:10.1007/s11164-018-3321-4

Cited by 14 publications

(2 citation statements)

References 47 publications

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“…Some of amido alkyl β-naphthols with medicinal and biological properties are shown in Figure 1 [7][8][9]. Amido alkyl β-naphthols can convert to oxazine derivatives which are one of the important compounds in medicinal and industrial [10,11]. It should be noted that amidomethyl β-naphtholes could be converted to important biological and pharmacological derivatives of by the hydrolysis reaction of amide.…”

Section: Introductionmentioning

confidence: 99%

Solvent free synthesis of amidoalkyl derivatives under green and convenient conditions

Sadeghi

Moradi

2021

Journal of Heterocyclic Chem

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Amidoalkyl derivatives are significant compounds due to their application in the preparation of potent drugs and important biological compounds. In this context, we presented a new method for the synthesis of amido alkyl β-naphthol and amidoalky naphthoquinones using ascorbic acid (vitamin C) as a natural and water-soluble catalyst under solvent-free conditions. Short reaction time, high yield of product, easy workup and low cost of catalyst are some of the advantages of this method. All the products were obtained in high to excellent yields and characterized by 1 HNMR, 13 CNMR, and FT-IR methods.

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Section: Introductionmentioning

confidence: 99%

Solvent free synthesis of amidoalkyl derivatives under green and convenient conditions

Sadeghi

Moradi

2021

Journal of Heterocyclic Chem

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“…Nanochemistry is becoming increasingly significant which involves the synthesis and application of nanoparticles of different sizes and shapes. [1][2][3][4][5][6][7][8][9] Nanoparticles are different from their bulk counterparts and show special properties. A considerable amount of attention to nanoparticles is due to their unique properties such as ease of availability, chemical inertness, high surface area to volume ratio, high activity and selectivity, thermal stability and low toxicity.…”

Section: Introductionmentioning

confidence: 99%

Molybdic Acid-Functionalized Nano-Fe3O4@TiO2 as a Novel and Magnetically Separable Catalyst for the Synthesis of Coumarin-Containing Sulfonamide Derivatives

Farahi

Karami

Abdollahi

2020

ACSi

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Supported molybdic acid on nano-Fe 3 O 4 @TiO 2 (Fe 3 O 4 @TiO 2 @(CH 2) 3 OMoO 3 H) has been successfully prepared, characterized and applied as a catalyst for the synthesis of sulfonamide containing coumarin moieties. The prepared Fe 3 O 4 nanoparticles by coprecipitation of Fe 2+ and Fe 3+ ions were treated with tetraethyl orthotitanate to obtain Fe 3 O 4 @TiO 2. By anchoring 3-chloropropyltriethoxysilan on Fe 3 O 4 @TiO 2 followed by reacting with molybdic acid, the desired catalyst was produced. The synthesized catalyst was characterized using XRD, SEM, EDS, FT-IR and VSM analysis. Fe 3 O 4 @TiO 2 @ (CH 2) 3 OMoO 3 H was used as a catalyst for the synthesis of sulfonamide containing coumarin moieties via a three-component reaction of aryl aldehydes, para-toluenesulfonamide and 4-hydroxycoumarin or 5,7-dihydroxy-4-methylcoumarin. The catalyst recovery test showed the catalyst is highly reusable without losing its activity.

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Synthesis, Docking Study and Biological Activities Evaluation of 1‐Amidoalkyl‐2‐naphthol Derivatives as Dual Inhibitors of Cholinesterase and α‐Glucosidase

Boudebbous

Boulebd

Bensouici³

et al. 2020

ChemistrySelect

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An efficient green synthesis of 1-amidoalkyl-2-naphthol derivatives 4 a-s has been developed, employing phenylboronic acid, by a three component one-pot condensation reaction of 2naphthol, a wide range of functionalized aromatic aldehydes and acetamide, or acrylamide under solvent-free conditions. This new protocol has the rewards of ecologically benign, easy workup along with good to excellent yields. Moreover, selected compounds were screened towards inhibition of cholinesterase. In vitro studies showed that some synthesized compounds have significant both AChE and BChE inhibitory activities compared to Galanthamine (reference drug). Compounds 4 p and 4 s were the most effective showing high potential AChE and BChE inhibitory activities with respective IC 50 values of 13.81 � 0.54 μM and 31.70 � 1.29 μM. Subsequent evaluation of the α-glucosidase inhibitory activity of the target molecules revealed that compound 4 s with an IC 50 value of 2.05 � 0.05 μM exhibited highest activity. These preliminary results provide promising sources of multifunctional agents and sheds light on their potential usage in medicine and in the pharmaceutical industries. Using molecular docking approach, we tried to get insights into binding interactions of our synthesized compounds to act as AChE and BChE inhibitors and understand the facts that underlie the relationships between structural modifications on these ligands and their efficacy.

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Nanomagnetite-supported molybdenum oxide (nanocat-Fe-Mo): an efficient green catalyst for multicomponent synthesis of amidoalkyl naphthols

Cited by 14 publications

References 47 publications

Solvent free synthesis of amidoalkyl derivatives under green and convenient conditions

Solvent free synthesis of amidoalkyl derivatives under green and convenient conditions

Molybdic Acid-Functionalized Nano-Fe3O4@TiO2 as a Novel and Magnetically Separable Catalyst for the Synthesis of Coumarin-Containing Sulfonamide Derivatives

Synthesis, Docking Study and Biological Activities Evaluation of 1‐Amidoalkyl‐2‐naphthol Derivatives as Dual Inhibitors of Cholinesterase and α‐Glucosidase

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