Nanogold morphologies with the same surface chemistry provoke a different innate immune response: An in-vitro and in-vivo study

Usman, Muhammad; Sarwar, Yasra; Abbasi, Rashda; Ishaq, Hafiz Muhammad; Iftikhar, Maryam; Hussain, Irshad; Demirdogen, Ruken Esra; Ihsan, Ayesha

doi:10.1016/j.impact.2022.100419

Cited by 4 publications

(4 citation statements)

References 72 publications

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“…In addition, when produced as a nanomaterial, Np-Au can easily penetrate various membrane structures, making it conducive for drugs to enter the target tissues or cells. Np-Au nanomorphologies have also been studied in vitro and in vivo to investigate the immune response towards their presence [242] (Figure 9a). The surface of Np-Au nanomaterials can be further modified for different purposes to allow drug delivery to different tissues or organs in a directional manner [43].…”

Section: Porous Gold Nanostructures and Other Precious Metalsmentioning

confidence: 99%

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Porous Inorganic Nanomaterials: Their Evolution towards Hierarchical Porous Nanostructures

Jose,

Mathew,

Fernández-Navas

et al. 2024

Micro

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The advancement of both porous materials and nanomaterials has brought about porous nanomaterials. These new materials present advantages both due to their porosity and nano-size: small size apt for micro/nano device integration or in vivo transport, large surface area for guest/target molecule adsorption and interaction, porous channels providing accessibility to active/surface sites, and exposed reactive surface/active sites induced by uncoordinated bonds. These properties prove useful for the development of different porous composition types (metal oxides, silica, zeolites, amorphous oxides, nanoarrays, precious metals, non-precious metals, MOFs, carbon nanostructures, MXenes, and others) through different synthetic procedures—templating, colloidal synthesis, hydrothermal approach, sol-gel route, self-assembly, dealloying, galvanostatic replacement, and so—for different applications, such as catalysis (water-splitting, etc.), biosensing, energy storage (batteries, supercapacitors), actuators, SERS, and bio applications. Here, these are presented according to different material types showing the evolution of the structure design and development towards the formation of hierarchical porous structures, emphasizing that the formation of porous nanostructures came about out of the desire and need to form hierarchical porous nanostructures. Common trends observed across these different composition types include similar (aforementioned) applications and the use of porous nanomaterials as templates/precursors to create novel ones. Towards the end, a discussion on the link between technological advancements and the development of porous nanomaterials paves the way to present future perspectives on these nanomaterials and their hierarchical porous architectures. Together with a summary, these are given in the conclusion.

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Section: Porous Gold Nanostructures and Other Precious Metalsmentioning

confidence: 99%

“…Usman, M.; Sarwar, Y.; Abbasi, R.; Ishaq, H.M.; Iftikhar, M.; Hussain, I.; Demirdogen, R.E. ; Ihsan, A., Nanogold morphologies with the same surface chemistry provoke a different innate immune response: an in vitro and in vivo study, 100419, Copyright 2022, with permission from Elsevier [242]…”

mentioning

confidence: 99%

Porous Inorganic Nanomaterials: Their Evolution towards Hierarchical Porous Nanostructures

Jose,

Mathew,

Fernández-Navas

et al. 2024

Micro

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“…Notably, Au‐NPs morphologies with the same surface chemistry elicited different innate immune responses in different environments in vivo and in vitro. This may be related to the complex interactions between Au‐NPs and other systems in vivo 198 . In summary, most NPs can activate the innate immune response and induce the expression of inflammatory factors in cells, resulting in overactivation or immunosuppression of the innate immune response.…”

Section: Toxic Effects Of Nps On Healthmentioning

confidence: 99%

“…This may be related to the complex interactions between Au‐NPs and other systems in vivo. 198 In summary, most NPs can activate the innate immune response and induce the expression of inflammatory factors in cells, resulting in overactivation or immunosuppression of the innate immune response. However, there are few reports on the regulation of NPs on specific immunity.…”

Section: Toxic Effects Of Nps On Healthmentioning

confidence: 99%

Nanoparticles‐induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models

Xuan

Zhao

Skonieczna

et al. 2023

MedComm

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Nanoparticles (NPs) have become one of the most popular objects of scientific study during the past decades. However, despite wealth of study reports, still there is a gap, particularly in health toxicology studies, underlying mechanisms, and related evaluation models to deeply understanding the NPs risk effects. In this review, we first present a comprehensive landscape of the applications of NPs on health, especially addressing the role of NPs in medical diagnosis, therapy. Then, the toxicity of NPs on health systems is introduced. We describe in detail the effects of NPs on various systems, including respiratory, nervous, endocrine, immune, and reproductive systems, and the carcinogenicity of NPs. Furthermore, we unravels the underlying mechanisms of NPs including ROS accumulation, mitochondrial damage, inflammatory reaction, apoptosis, DNA damage, cell cycle, and epigenetic regulation. In addition, the classical study models such as cell lines and mice and the emerging models such as 3D organoids used for evaluating the toxicity or scientific study are both introduced. Overall, this review presents a critical summary and evaluation of the state of understanding of NPs, giving readers more better understanding of the NPs toxicology to remedy key gaps in knowledge and techniques.

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Nanotoxicology: A Threat to the Environment and Human Health

Srivastava,

Sharma,

Arya

et al. 2024

Nanotechnology

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Nanogold morphologies with the same surface chemistry provoke a different innate immune response: An in-vitro and in-vivo study

Cited by 4 publications

References 72 publications

Porous Inorganic Nanomaterials: Their Evolution towards Hierarchical Porous Nanostructures

Porous Inorganic Nanomaterials: Their Evolution towards Hierarchical Porous Nanostructures

Nanoparticles‐induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models

Nanotoxicology: A Threat to the Environment and Human Health

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