Nanogels for biomedical applications

Tsintou, Magdalini; Wang, Cang; Dalamagkas, Kyriakos; Ding, Wei; Zhang, Yinan; Niu, Wanting

doi:10.1016/b978-0-08-100963-5.00005-7

Cited by 11 publications

(5 citation statements)

References 181 publications

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“…[13] Such theranostic microgels combine therapeutic and diagnostic approaches and represent interesting candidates for advances treatment capabilities, where the pathological site and its extent is visualized, while drug delivery on-site can be monitored at the same time. [225] Such theranostic microgel systems for targeted cancer diagnosis and therapy have gained increasing attention in recent years. [226]…”

Section: Microgels For Imaging and Diagnosticsmentioning

confidence: 99%

Translating Therapeutic Microgels into Clinical Applications

Kittel

Kuehne

Laporte

2021

Adv Healthcare Materials

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Microgels are crosslinked, water‐swollen networks with a 10 nm to 100 µm diameter and can be modified chemically or biologically to render them biocompatible for advanced clinical applications. Depending on their intended use, microgels require different mechanical and structural properties, which can be engineered on demand by altering the biochemical composition, crosslink density of the polymer network, and the fabrication method. Here, the fundamental aspects of microgel research and development, as well as their specific applications for theranostics and therapy in the clinic, are discussed. A detailed overview of microgel fabrication techniques with regards to their intended clinical application is presented, while focusing on how microgels can be employed as local drug delivery materials, scavengers, and contrast agents. Moreover, microgels can act as scaffolds for tissue engineering and regeneration application. Finally, an overview of microgels is given, which already made it into pre‐clinical and clinical trials, while future challenges and chances are discussed. This review presents an instructive guideline for chemists, material scientists, and researchers in the biomedical field to introduce them to the fundamental physicochemical properties of microgels and guide them from fabrication methods via characterization techniques and functionalization of microgels toward specific applications in the clinic.

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Section: Microgels For Imaging and Diagnosticsmentioning

confidence: 99%

Translating Therapeutic Microgels into Clinical Applications

Kittel

Kuehne

Laporte

2021

Adv Healthcare Materials

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“…They have shown great biocompatibility and biodegradability in both in vitro and in vivo studies and have been widely used in biomedical science in the areas of imaging, diagnosis, drug delivery, tissue engineering, biosensors, etc. Their sizes, shapes, charges, and surface chemistries can be easily tuned, which offers nanogels many advantages as nanocarriers in the delivery of small molecules, proteins, genes, and other therapies [102].…”

Section: Polymer Hydrogels and Nanogelsmentioning

confidence: 99%

Polymers and Polymer Nanocomposites for Cancer Therapy

Feldman

2019

Applied Sciences

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Synthetic polymers, biopolymers, and their nanocomposites are being studied, and some of them are already used in different medical areas. Among the synthetic ones that can be mentioned are polyolefins, fluorinated polymers, polyesters, silicones, and others. Biopolymers such as polysaccharides (chitosan, hyaluronic acid, starch, cellulose, alginates) and proteins (silk, fibroin) have also become widely used and investigated for applications in medicine. Besides synthetic polymers and biopolymers, their nanocomposites, which are hybrids formed by a macromolecular matrix and a nanofiller (mineral or organic), have attracted great attention in the last decades in medicine and in other fields due to their outstanding properties. This review covers studies done recently using the polymers, biopolymers, nanocomposites, polymer micelles, nanomicelles, polymer hydrogels, nanogels, polymersomes, and liposomes used in medicine as drugs or drug carriers for cancer therapy and underlines their responses to internal and external stimuli able to make them more active and efficient. They are able to replace conventional cancer drug carriers, with better results. Appl. Sci. 2019, 9, 3899 2 of 24 nanocomposites offer numerous opportunities in diverse applications, including nanocarriers, tissue engineering, antimicrobials, sensors, etc. These new groups of materials have gained significant research interest due to their novel properties, which are gained through the addition of nanofillers. Polymer nanocomposites have significant potential in disease theranostics, and nanotechnology brings great promise in cancer drug carriers [4].Chemotherapy implies the use of drugs and, besides the drugs, carriers. Common products used as carriers include synthetic polymers, biopolymers, and polymer nanocomposites.Some of the most useful drugs for chemotherapy are toxic chemicals able to inhibit the proliferation of cancer cells. The use of chemotherapeutic drugs has been in part hindered by their poor solubility in water, their short biological half-life, their lack of targeting ability, and the development of multidrug resistance [5]. In the last decades, nanoparticles have shown significant promise as an oncology treatment modality. Responsive polymers represent a promising class of nanoparticles that can trigger delivery through the exploitation of a specific stimuli. Response to a stimulus is one of the most basic processes found in living systems. A tutorial review highlighted the recent developments in polymer-based approaches to internally responsive nanoparticles for oncology [6].One important goal of medicine is to develop carriers that can selectively deliver anticancer drugs to tumor cells with no or minimal side effects in healthy cells [7,8].Polymers and their nanocomposites in different forms, such as micelles, hydrogels, polymersomes, and liposomes, have important potential in cancer diagnosis and treatment.Nanocomposites are popular in many areas due to properties such as their unique design capacity, eco-friendly nature, ...

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“…This is appealing for drug delivery, for biosensors or for tissue engineering. [ 18 ] Here harsh chemicals like bases and acids that are used for the dissolution of AAO cannot be applied, because they may corrode the soft materials.…”

Section: Introductionmentioning

confidence: 99%

Anodic Aluminum Oxide Membrane Assisted Extrusion of Polymer Solutions for Hydrogel Formation

Schulte

Alhusaini

Awan

et al. 2023

Macromolecular Symposia

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The potential of polymeric nanostructures obtained by extruding polymer solutions through reusable anodic aluminum oxide (AAO) nanopores for the fabrication of nanostructures is investigated systematically to be able to unveil the potential impact of structure on cell culturing. Thus, nanostructured Na‐alginate and poly(vinyl alcohol) (PVA) polymers as well as blended alginate/PVA hydrogels are fabricated. Na‐alginate and PVA fibers with different dimensions can be obtained. By extruding Na‐alginate solutions into a non‐solvent also networks of uniform nanofibers (diameter <20 nm) are generated. PVA forms agglomerations of nanofibers and nanoparticles with diameter >100 nm. In addition, cell line‐dependent behavior of the cross‐linked PVA/alginate nanofibers is observed, which is characterized by reduced cell adhesion and cluster formation of PaTu 8988t cells on these blend nanofibers compared to normal cell adhesive behavior of NIH 3T3 cells.

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Nanogels for biomedical applications

Cited by 11 publications

References 181 publications

Translating Therapeutic Microgels into Clinical Applications

Translating Therapeutic Microgels into Clinical Applications

Polymers and Polymer Nanocomposites for Cancer Therapy

Anodic Aluminum Oxide Membrane Assisted Extrusion of Polymer Solutions for Hydrogel Formation

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