Nanogels as potential nanomedicine carrier for treatment of cancer: A mini review of the state of the art

Soni, Govind; Yadav, Khushwant S.

doi:10.1016/j.jsps.2014.04.001

Cited by 160 publications

(84 citation statements)

References 54 publications

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“…They can be adapted for targeted delivery by appropriate surface modifications. 78 Nanogels can be simply prepared by proper combination of amphiphilic block copolymers leading to binding of oppositely charged polymeric chains. 79 One method for preparation of large pore-size nanogels is chemical crosslinking.…”

Section: Ph-sensitive Nanocarriersmentioning

confidence: 99%

pH‐Sensitive stimulus‐responsive nanocarriers for targeted delivery of therapeutic agents

Karimi

Eslami

Zangabad

et al. 2016

WIREs Nanomed Nanobiotechnol

185

105

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In recent years miscellaneous smart micro/nanosystems that respond to various exogenous/endogenous stimuli including temperature, magnetic/electric field, mechanical force, ultrasound/light irradiation, redox potentials, and biomolecule concentration have been developed for targeted delivery and release of encapsulated therapeutic agents such as drugs, genes, proteins, and metal ions specifically at their required site of action. Owing to physiological differences between malignant and normal cells, or between tumors and normal tissues, pH-sensitive nanosystems represent promising smart delivery vehicles for transport and delivery of anticancer agents. Furthermore, pH-sensitive systems possess applications in delivery of metal ions and biomolecules such as proteins, insulin, etc., as well as co-delivery of cargos, dual pH-sensitive nanocarriers, dual/multi stimuli-responsive nanosystems, and even in the search for new solutions for therapy of diseases such as Alzheimer’s. In order to design an optimized system, it is necessary to understand the various pH-responsive micro/nanoparticles and the different mechanisms of pH-sensitive drug release. This should be accompanied by an assessment of the theoretical and practical challenges in the design and use of these carriers.

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Section: Ph-sensitive Nanocarriersmentioning

confidence: 99%

pH‐Sensitive stimulus‐responsive nanocarriers for targeted delivery of therapeutic agents

Karimi

Eslami

Zangabad

et al. 2016

WIREs Nanomed Nanobiotechnol

185

105

View full text Add to dashboard Cite

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“…Additionally, there is an ease to not only synthesizing nanogels but chemically modifying them as well. [29,64] Preparing nanogels is simple, and neither mechanical energy nor organic solvents are required for their production. [64] Additional modifications of nanogels can aid in decreasing associated cytotoxicity.…”

Section: Nanogelsmentioning

confidence: 99%

“…[29,64] Preparing nanogels is simple, and neither mechanical energy nor organic solvents are required for their production. [64] Additional modifications of nanogels can aid in decreasing associated cytotoxicity. [65] Studies concerning nanogels in vivo have demonstrated their ability to protect their cargo from degradation.…”

Section: Nanogelsmentioning

confidence: 99%

An Overview of Various Carriers for siRNA Delivery

Marquez¹,

Madu²,

Lü³

2018

Oncomedicine

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RNA interference through the use of short interfering molecules known as short interfering RNA (siRNA) has the potential to greatly advance research in treatments for many diseases because it has the ability to silence the expression of specific genes by helping degrade target mRNA. However, challenges to siRNA delivery have made the development of safe and effective delivery systems paramount in siRNA research. Various types of delivery systems have been proposed and investigated for siRNA delivery and therapy. Although viral vectors have been established to be the most effective in delivering siRNA molecules, they also raise many concerns over biosafety, especially concerning immunogenicity. Therefore, many researchers have begun to investigate and study non-viral vectors. Non-viral vectors are studied because they are typically considered to be safer than viral vectors albeit less efficient as well. The three general non-viral vectors that have been studied for siRNA delivery are lipid-based, non-lipid organic-based, and non-lipid inorganic-based carriers. Within those general parameters of non-viral vector classification are subtypes that are each unique with their own characteristic benefits and downsides. Many of these carriers, as well as even naked siRNA, do have the potential to be modified so that siRNA delivery could be further enhanced with benefits such as greater stability and duration. Researchers still must be wary with alterations as to not interfere with siRNA function. Currently, widespread siRNA therapeutics are still out of reach, but as more advancements in siRNA research including research on their delivery mechanisms are established, the goal of integrating siRNA therapy into the treatment of a multitude of diseases becomes increasingly more of a possibility. Researchers are currently investigating how siRNA can be used to not just treat cancer but ocular and neurodegenerative diseases as well as many others. There are still many obstacles to face and overcome before siRNA therapy can be implemented into the treatment of many diseases, and more research must still be conducted concerning siRNA delivery systems. Many advancements pertaining to siRNA carriers have been made, and many more are likely on their way.

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“…Polymer nanogels, which are nanosized particles of hydrogels, integrate the characteristics of hydrogels and nanoparticles into one platform . In comparison to other polymer‐based drug nanocarriers, e.g., micelles, liposomes, and polymer–drug conjugates, nanogels have significant advantages . First, polymer nanogels can be formed by a large variety of materials, including gelatin, chitosan, poly( N ‐isopropylacrylamide) (PNIPAM), polypeptides, and many others .…”

Section: Introductionmentioning

confidence: 99%

Advances in Stimuli‐Responsive Polypeptide Nanogels

et al. 2018

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Polymer nanogels, which are nanosized particles of hydrogels formed by physically or chemically crosslinking polymers, are one of the most promising nanoplatforms for use in biomedical applications, including drug delivery, gene therapy, and bioimaging. Polypeptide nanogels exhibit many advantages for applications in biomedical fields, including stable 3D structures, high drug‐loading efficiency, excellent biocompatibility, stimuli responsiveness, and so forth. More specifically, smart polypeptide nanogels undergo suitable transitions under endogenous (e.g., reduction, reactive oxygen species, pH, and enzymes) or exogenous stimuli (e.g., light, temperature, voltage, and magnetic fields) for on‐demand drug delivery. Here, a comprehensive introduction to the preparation and applications of diverse stimuli‐responsive polypeptide nanogels is given. Moreover, the opportunities and challenges of polypeptide nanogels for the development of biomedicine are briefly predicted.

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Nanogels as potential nanomedicine carrier for treatment of cancer: A mini review of the state of the art

Cited by 160 publications

References 54 publications

pH‐Sensitive stimulus‐responsive nanocarriers for targeted delivery of therapeutic agents

pH‐Sensitive stimulus‐responsive nanocarriers for targeted delivery of therapeutic agents

An Overview of Various Carriers for siRNA Delivery

Advances in Stimuli‐Responsive Polypeptide Nanogels

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