Nanogels as potential drug nanocarriers for CNS drug delivery

Vashist, Arti; Kaushik, Ajeet; Vashist, Atul; Bala, Jyoti; Nikkhah-Moshaie, Roozbeh; Sagar, Vidya; Nair, M. G.

doi:10.1016/j.drudis.2018.05.018

Cited by 110 publications

(84 citation statements)

References 69 publications

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“…Therefore, combination therapies, especially nanocarrier-based codelivery systems including micelles [99], liposomes [100], polymeric NPs [101], noble metal NPs [102] and inorganic NPs [103], have been thriving as promising strategies for the treatment of cancer. Nanogels are ideal candidates for drug codelivery due to their unique properties, such as their good biocompatibility, excellent stability, considerable loading capacity, as well as the controlled drug release ability with environmental stimulation [104].…”

Section: Application Of Nanogels In Combinational Therapymentioning

confidence: 99%

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

et al. 2020

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Nanogel-based nanoplatforms have become a tremendously promising system of drug delivery. Nanogels constructed by chemical crosslinking or physical self-assembly exhibit the ability to encapsulate hydrophilic or hydrophobic therapeutics, including but not limited to small-molecule compounds and proteins, DNA/RNA sequences, and even ultrasmall nanoparticles, within their 3D polymer network. The nanosized nature of the carriers endows them with a specific surface area and inner space, increasing the stability of loaded drugs and prolonging their circulation time. Reactions or the cleavage of chemical bonds in the structure of drug-loaded nanogels have been shown to trigger the controlled or sustained drug release. Through the design of specific chemical structures and different methods of production, nanogels can realize diverse responsiveness (temperature-sensitive, pH-sensitive and redox-sensitive), and enable the stimuli-responsive release of drugs in the microenvironments of various diseases. To improve therapeutic outcomes and increase the precision of therapy, nanogels can be modified by specific ligands to achieve active targeting and enhance the drug accumulation in disease sites. Moreover, the biomembrane-camouflaged nanogels exhibit additional intelligent targeted delivery features. Consequently, the targeted delivery of therapeutic agents, as well as the combinational therapy strategy, result in the improved efficacy of disease treatments, though the introduction of a multifunctional nanogel-based drug delivery system.

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Section: Application Of Nanogels In Combinational Therapymentioning

confidence: 99%

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

et al. 2020

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“…Some of them can be used to the delivery of drugs to the central nervous system due to their capability of being injected into the intrathecal space. 107 However, drug release in brain is yet challenging due to the blood brain barrier. 108 Antiparkinsonian drugs such as levodopa and dopamine were entrapped into alginate and xanthan gum in order to evaluate the drug release in vitro and neural cell response.…”

Section: Drug Deliverymentioning

confidence: 99%

Magneto-Responsive Hydrogels: Preparation, Characterization, Biotechnological and Environmental Applications

Frachini¹,

Petri²

2019

J. Braz. Chem. Soc.

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Hydrogels are hydrophilic three-dimensional networks able to hold large amount of water and hydrophilic molecules. Magneto-responsive hydrogels comprise of magnetic nanoparticles dispersed in polymeric networks that can be manipulated under external magnetic field. This review aims at (i) giving a brief overview on the evolution of hydrogels until the design and development of magnetic hydrogels; (ii) describing the types of hydrogels and the basic concepts about superparamagnetic iron oxide nanoparticles, as well as the preparation and characterization of magneto-responsive hydrogels; (iii) displaying the relevant applications of magneto-responsive hydrogels for drug delivery, regenerative medicine of tissues, cancer therapy and environmental issues and (iv) highlighting the challenges and future trends of magneto-responsive hydrogels for 3D and 4D printing.

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“…Experts have suggested the development of least-component based nano-pharmacology wherein selected drug nano-carriers should be biocompatible and stimuli-responsive. Such materials can perform controlled drug delivery and release, even in the brain (Figure 1; Kaushik et al, 2016bKaushik et al, , 2019Nair et al, 2016;Rodriguez et al, 2017;Vashist et al, 2018a). f) Nanotechnology assisted combinational therapy is emerging as one of the best alternatives in conventional approaches.…”

Section: Introductionmentioning

confidence: 99%