Nanogel Engineering by Associating Polymers for Biomedical Applications

Sasaki, Yoshihiro; Akiyoshi, Kazunari

doi:10.1002/9783527646425.ch8

Cited by 11 publications

(5 citation statements)

References 100 publications

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“…Nanogels have greater potential as novel, safe, and effective carrier system for solubility enhancement of poor soluble drugs due to smaller size, large surface area, high drug-loading capacity, and stability. They are very promising in drug delivery application and have the ability to reach the smallest capillaries and can penetrate tissues through different pathways due to their extra small size (21,22). Solubility of poorly soluble drugs in the core of nanogels is an important consideration in designing nanodrug deliver systems.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Poloxamer-407-Co-Poly (2-Acrylamido-2-Methylpropane Sulfonic Acid) Cross-linked Nanogels for Solubility Enhancement of Olanzapine: Synthesis, Characterization, and Toxicity Evaluation

2020

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Current study is focused to enhance the solubility of poorly soluble drug olanzapine (OLZ) by nanogels drug delivery system, as improved solubility is one of the most important applications of nanosystems. Poor solubility is a major issue, and 40% of marketed and about 75% of new active pharmaceutical ingredients are poorly water soluble which significantly affect the bioavailability and therapeutic effects of these drugs. In this study, nanogels, a promising system for solubility enhancement, were developed by freeradical polymerization technique. Different formulations were synthesized in which poloxamer-407 was cross-linked with 2-acrylamido-2-methylpropane sulfonic acid (AMPS) with the help of cross-linker methylene bisacrylamide (MBA). The chemically cross-linked nanogels were characterized by Fourier transform infrared spectroscopy (FT-IR), thermos gravimetric analysis (TGA), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), zeta size, swelling, sol-gel analysis, drug loading, solubility, and in vitro drug release studies. In order to determine the biocompatibility and cytotoxicity of nanogels to biological system, toxicity study on rabbits was also carried out. It was confirmed that the developed nanogels was thermally stable, safe, effective, and compatible to biological system, and the solubility of olanzapine (OLZ) was enhanced up to 38 folds as compared with reference product.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Poloxamer-407-Co-Poly (2-Acrylamido-2-Methylpropane Sulfonic Acid) Cross-linked Nanogels for Solubility Enhancement of Olanzapine: Synthesis, Characterization, and Toxicity Evaluation

2020

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“…[20] The influence of the hydrophobic structures and the degree of substitution, on the physicochemical properties of the polysaccharide nanogels, was investigated in detail for a number of polysaccharides, leading to design rules with respect to the hydrophobic substances (Figure 2a). [21] Long alkyl chains [22] and deoxycholic acid [23] can also be used as hydrophobic association units.…”

Section: Design Of Physically Cross-linked Nanogelsmentioning

confidence: 99%

Nanogel Tectonics for Tissue Engineering: Protein Delivery Systems with Nanogel Chaperones

Hashimoto

Mukai

Sasaki

et al. 2018

Adv Healthcare Materials

Self Cite

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Amphiphilic polysaccharide self-assembled (SA) nanogels are promising protein carriers owing to their chaperone-like activity that allows them to nanoencapsulate proteins within their polymer networks. The chaperoning function is an important concept that has led to breakthroughs in the development of effective protein drug delivery systems by stabilizing formulations and controlling the quality of unstable proteins. Recently, nanogel-tectonic materials that integrate SA nanogels as building blocks have been designed as new hydrogel biomaterials. This article describes recent progress and applications of SA nanogel tectonic materials as protein delivery systems for tissue engineering.

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“…The CHP nanogel has been developed and applied as a nanocarrier for protein DDSs in particular. In addition, various polysaccharides, such as cycloamylose, mannan, cyclic dextran, and glycogen [ 2 ], have been used as main chains and modified with cholesterol groups to form nanogels. Proteins, such as antigens for vaccines, cytokines, and hormones, can be encapsulated and released in vivo.…”

Section: Introductionmentioning

confidence: 99%

Cholesterol-Bearing Polysaccharide-Based Nanogels for Development of Novel Immunotherapy and Regenerative Medicine

Adachi,

Tahara,

Yamamoto

et al. 2024

Gels

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Novel functional biomaterials are expected to bring about breakthroughs in developing immunotherapy and regenerative medicine through their application as drug delivery systems and scaffolds. Nanogels are defined as nanoparticles with a particle size of 100 nm or less and as having a gel structure. Nanogels have a three-dimensional network structure of cross-linked polymer chains, which have a high water content, a volume phase transition much faster than that of a macrogel, and a quick response to external stimuli. As it is possible to transmit substances according to the three-dimensional mesh size of the gel, a major feature is that relatively large substances, such as proteins and nucleic acids, can be taken into the gel. Furthermore, by organizing nanogels as a building block, they can be applied as a scaffold material for tissue regeneration. This review provides a brief overview of the current developments in nanogels in general, especially drug delivery, therapeutic applications, and tissue engineering. In particular, polysaccharide-based nanogels are interesting because they have excellent complexation properties and are highly biocompatible.

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Nanogel Engineering by Associating Polymers for Biomedical Applications

Cited by 11 publications

References 100 publications

RETRACTED ARTICLE: Poloxamer-407-Co-Poly (2-Acrylamido-2-Methylpropane Sulfonic Acid) Cross-linked Nanogels for Solubility Enhancement of Olanzapine: Synthesis, Characterization, and Toxicity Evaluation

RETRACTED ARTICLE: Poloxamer-407-Co-Poly (2-Acrylamido-2-Methylpropane Sulfonic Acid) Cross-linked Nanogels for Solubility Enhancement of Olanzapine: Synthesis, Characterization, and Toxicity Evaluation

Nanogel Tectonics for Tissue Engineering: Protein Delivery Systems with Nanogel Chaperones

Cholesterol-Bearing Polysaccharide-Based Nanogels for Development of Novel Immunotherapy and Regenerative Medicine

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