Nanogel Engineered Polymeric Micelles for Drug Delivery

Shidhaye, Supriya; Lotlikar, Vishwanath; Malke, Sheetal; Kadam, Vilasrao

doi:10.2174/157488508785747880

Cited by 25 publications

(20 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Polymeric nanogels can be synthesized by three straightforward methods: (i) cross-linking polymer chains within already formed nanoparticles using, for example, emulsion polymerization technique [47][48][49], (ii) polymerization within the liposomal interior followed by the lipid bilayer removal [9], and (iii) photolithographic fabrication of submicrometer hydrogel particles using the PRINT technique [50,51] or step and flash imprint lithography (S-FIL) [52] as an alternative nanoimprint photolithographic approach.…”

Section: Hydrogel Corementioning

confidence: 99%

“…[47,[100][101][102][103][104][105]. In general, various types of hydrogels based upon either natural (e.g., hyaluronic acid, collagen, chondroitin sulfate, alginates, fibrin, and chitosan) and synthetic polymers made of neutral (e.g., 2-hydroxyethyl methacrylate, N-alkylmethacrylamides, N-alkylacylamides, and N,N-dialkylacrylamides), acidic (e.g., acrylic acid, metacrylic acid, and 2-acrylamido-2-methyl propane sulfonic acid), or basic (e.g., N,N-dialkylaminoethyl methacrylate, 1-vinylimidasole, and methacryloyoloxyethyltrialkylammonium bromide) monomers have been prepared, studied, and used in numerous applications (bioseparation, tissue engineering, sensing and molecular recognition, drug and gene delivery, controlled release, artificial muscles, and flow control).…”

Section: A Variety Of Possible Hydrogel Coresmentioning

confidence: 99%

See 1 more Smart Citation

Lipobeads

Казаков¹

2017

Liposomes

View full text Add to dashboard Cite

A combination of lipid bilayer and cross-linked polymer network is the logical step in development of polymeric and liposomal nanoscopic systems to provide the natural level of functionality. From liposomal systems, lipobeads borrow the welldeveloped methods for preparation, diversity of lipids to control the properties of a lipid bilayer, biocompatibility of the lipid bilayer, possibility to vary size and morphology (passive targeting), availability of the external surface for attachment of various ligands (active targeting), encapsulation efficiency of both hydrophilic and hydrophobic molecules. Mechanical stability of the lipid bilayer and environmental responsiveness of the whole structure are the properties that hydrogel core brings to the new construct. The reports reviewed in this chapter demonstrate that lipobeads of nanometer and micrometer sizes can be prepared in different media, retain their stimuli responsiveness under physiological conditions, exhibit both reversible and irreversible aggregation, can be loaded with both small and high molecular weight molecules. As a platform for drug delivery systems, lipobeads have already been loaded with chemotherapeutics, malaria vaccine, and dermatological agent providing different controlled release profiles without leakage. Consecutive multistep triggering, new schemes of drug release, combined drug delivery, vesobeads, proteolipobeads, enzyme-containing lipobeads, and hemi-lipobeads are the directions for their future development.

show abstract

Section: Hydrogel Corementioning

confidence: 99%

Section: A Variety Of Possible Hydrogel Coresmentioning

confidence: 99%

Lipobeads

Казаков¹

2017

Liposomes

View full text Add to dashboard Cite

show abstract

“…Through variation of the cross-linked structure, size, and material selection, a multitude of options and effects are possible [97,[117][118][119][120][121]. The biggest difference between nanogels and other PNPs is that their structure is cross-linked either physically or chemically and will hydrolytically swell, and, depending on the polymers and cross-linking chemistry used, degradation can be pH responsive which has been extensively utilized as a passive targeting technique [120,122]. This swelling force, when in an aqueous environment, can be produced through protonation/deprotonation, which will increase the mesh size until equilibrium is met with the cross-links' tension force.…”

Section: Polymeric Nanogelsmentioning

confidence: 99%

“…In an aqueous solution, both the polymer and the cross-linking molecules are dissolved before being added to a surfactant-containing organic solution. This produces inversed polymeric micelles, and then, through irradiation, polymerization is initiated and chemically cross-linked nanogels are formed [120].…”

Section: Emulsion Polymerizationmentioning

confidence: 99%

Polymeric Nanoparticles

Vasilakes¹,

Dziubla²,

Wattamwar³

2013

Engineering Polymer Systems for Improved Drug Delivery

View full text Add to dashboard Cite

“…Stimuli-sensitive nanohydrogels containing bioactive specific ligands seem to be an effective strategy [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Polymeric Nanohydrogels of Poly(N-Isopropylacrylamide) Combined with Others Functionalized Monomers: Synthesis and Characterization

Luztonó¹,

Donates²,

Ramirez³

et al. 2014

JBNB

View full text Add to dashboard Cite

Nanohydrogels from inverse microemulsion (w/o) polymerization, at 25˚C, of N-isopropylacrylamide (NIPA) and functionalized monomers are described. The functionalized monomers were: N-(pyridine-4-ylmethyl) acrylamide (NP4MAM) and tert-butyl 2-acrylamidoethyl carbamate (2AAECM). The polymeric nanohydrogel obtained was characterized by attenuated total reflectance Fourier-transformed infrared spectroscopy (ATR-FTIR) and proton nuclear magnetic resonance spectrometry ( 1 HNMR), while their morphology and particle size was assessed by scanning electron microscopy (SEM) and dynamic light scattering. Their thermal properties were studied by Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA). As a preliminary measure of biocompatibility, in vitro evaluations of the nanohydrogels were carried out by cellular toxicity (colon carcinoma cells, CT-26) and hemocompatibility tests. These evaluations showed that these nanohydrogels were not toxic in the examined concentration range and exhibited preliminary blood compatibility; therefore they could be used in biomedical applications.

show abstract

Nanogel Engineered Polymeric Micelles for Drug Delivery

Cited by 25 publications

References 0 publications

Lipobeads

Lipobeads

Polymeric Nanoparticles

Polymeric Nanohydrogels of Poly(N-Isopropylacrylamide) Combined with Others Functionalized Monomers: Synthesis and Characterization

Contact Info

Product

Resources

About