NANOG regulates the proliferation of PCSCs via the TGF-β1/SMAD pathway

Liu, Changming; Sheng, Mingxiong; Lin, Liheng; Li, Huizhang; Guo, Shanming; Zhang, Jiabin; Chen, Guangbing; Chen, Huihong

doi:10.1515/med-2020-0221

Cited by 6 publications

(2 citation statements)

References 28 publications

(27 reference statements)

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“…It contains the homeobox domain that can regulate the embryogenesis, cellular reprogramming, cancer stemness and migration through complex interactions with SOX2 [26]. The reported article also indicated that NANOG can promote prostate cancer cell proliferation via activating TGF-β signaling that can induce downstream components including the phosphorylation of SMAD [27]. N-cadherin is a member of the cadherin family being widely discussed for their active role in epithelial-mesenchymal transition (EMT).…”

Section: Discussionmentioning

confidence: 95%

Transplanting Heterologous Mitochondria from Human Umbilical Vein Endothelial Cells Reduces the Malignancy of Melanoma Cells

Kuo¹,

Cheng²,

Tsai³

et al. 2023

Preprint

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The development of using mitochondrial transplantation in medical therapy are currently discussed. According to the endosymbiotic theory, the movement of mitochondria between different cells is possible. Therefore, an idea of transferring the mitochondria purified from the cells with a limited lifespan to shorten the lifespan of immortal cancer cells was generated. Human umbilical vein endothelial cell (HUVEC) is a kind of primary cell with a limited lifespan. In the present study, the mitochondria purified from HUVEC were applied to alter the malignance of B16F10 melanoma cell. In the comparison of the basic function of mitochondria, HUVEC mitochondria exhibited a higher mitochondrial membrane potential (MMP), while the lower levels in ATP, mitochondrial DNA (mt-DNA) and mitochondrial protein (mt-protein) as compared to melanoma B16F10. After transplanted the B16F10 with HUVEC mitochondria, the migration, invasion, and the proteins involved in cancer stemness were decreased, however, the proteins involved in cell proliferation, such as cyclin D1 and cyclin E1 were increased. In addition, the levels of ATP, mt-DNA and mt-protein of B16F10 were also reduced. As for the dynamics of mitochondria, the reduced expressions of DRP1 and LC3 II revealed that transferred mitochondria can attenuate the mitophagy of B16F10. In mice, inoculated the B16F10 carrying the transplanted HUVEC mitochondria resulted in the larger size of tumor, which is corresponded to the higher levels of cyclin D1 and E1. Interestingly, the lower expressions of N-cadherin, α-SMA and MMP-9 reveled the tumor were decreased in mesenchymal characteristics. Therefore, despite the HUVEC mitochondria did not inhibit the proliferation of B16F10, the metastatic characteristic was reduced.

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Section: Discussionmentioning

confidence: 95%

Transplanting Heterologous Mitochondria from Human Umbilical Vein Endothelial Cells Reduces the Malignancy of Melanoma Cells

Kuo¹,

Cheng²,

Tsai³

et al. 2023

Preprint

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“…KLF functions as an AR activator and positively correlates with prostate cancer progression [100]. Liu et al (2020) established the role of NANOG in prostate cancer stem cell proliferation and its regulation through the SMAD signaling pathway [101]. NANOG silencing decreases phosphorylation events in TGF-β/SMAD signaling components which leads to the inhibition of prostate cancer stem cells proliferation, cell cycle arrest and induction of apoptosis [102].…”

Section: Do Aquaporins Serve As Prognostic Biomarkers For Prostate Ca...mentioning

confidence: 99%

Aquaporins as Prognostic Biomarker in Prostate Cancer

Kushwaha

Verma

Gupta

2023

Cancers

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Prostate cancer is a complex heterogeneous disease that affects millions of males worldwide. Despite rapid advances in molecular biology and innovation in technology, few biomarkers have been forthcoming in prostate cancer. The currently available biomarkers for the prognosis of prostate cancer are inadequate and face challenges, thus having limited clinical utility. To date, there are a number of prognostic and predictive biomarkers identified for prostate cancer but lack specificity and sensitivity to guide clinical decision making. There is still tremendous scope for specific biomarkers to understand the natural history and complex biology of this heterogeneous disease, and to identify early treatment responses. Accumulative studies indicate that aquaporins (AQPs) a family of membrane water channels may serve as a prognostic biomarker for prostate cancer in monitoring disease advancement. In the present review, we discuss the existing prostate cancer biomarkers, their limitations, and aquaporins as a prospective biomarker of prognostic significance in prostate cancer.

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LncRNA PICSAR binds to miR-485-5p and activates TGF-β1/Smad to promote abnormal proliferation of hypertrophic scar fibroblasts (HSFs) and excessive deposition of extracellular matrix (ECM)

Dong

Shi

2021

Med Mol Morphol

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NANOG regulates the proliferation of PCSCs via the TGF-β1/SMAD pathway

Cited by 6 publications

References 28 publications

Transplanting Heterologous Mitochondria from Human Umbilical Vein Endothelial Cells Reduces the Malignancy of Melanoma Cells

Transplanting Heterologous Mitochondria from Human Umbilical Vein Endothelial Cells Reduces the Malignancy of Melanoma Cells

Aquaporins as Prognostic Biomarker in Prostate Cancer

LncRNA PICSAR binds to miR-485-5p and activates TGF-β1/Smad to promote abnormal proliferation of hypertrophic scar fibroblasts (HSFs) and excessive deposition of extracellular matrix (ECM)

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