Nanofiltration of amino acid and peptide solutions: mechanisms of separation

Martin-Orue, Celia; Bouhallab, Saı̈d; Garem, Anita

doi:10.1016/s0376-7388(97)00325-6

Cited by 86 publications

(43 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pressure-driven membrane-based processes, such as UF and NF, are used to fractionate peptide mixtures and amino acids [13]. These types of membrane have been widely used to fractionate milk protein hydrolysates with the aim of enhancing their biological or functional properties [14][15].…”

Section: Overview Of Techniques Used For Peptide Fractionationmentioning

confidence: 99%

“…By that way, it is possible to obtain complete retention of the enzyme without deactivation problems typical of enzyme immobilization. Furthermore, EMR have been shown to improve the efficiency of enzyme-catalyzed bioconversion and to increase product yields [13,[30][31].…”

Section: Enzymatic Membrane Reactor Equipped With Membranes: First Stmentioning

confidence: 99%

“…The solute transfer through the membrane follow two main steps: distribution of ionic species at the selective interface according to their charge (both solutes and membrane) and transfer by a complex combination among diffusion, convection and electrophoretic mobility through the membrane, at least at low feed concentrations [13]. According to Donnan theory, the passage of charged solutes through a charged NF membrane is likely to be different whether they are considered to be co-ions, i.e.…”

Section: Nf Transport Mechanismmentioning

confidence: 99%

“…An additional research was later performed in order to understand the separation of peptide mixtures through NF membranes [13]. In this case, the solution tested was a mixture of 4 small peptides (4-7 residues) obtained by trypsin hydrolysis of caseinomacropeptide.…”

Section: Nf Applied To Amino Acid and Peptide Fractionation: Reviewmentioning

confidence: 99%

See 3 more Smart Citations

Advancements in the Fractionation of Milk Biopeptides by Means of Membrane Processes

Muro¹,

Riera²,

Fernández³

2013

Bioactive Food Peptides in Health and Disease

View full text Add to dashboard Cite

Section: Overview Of Techniques Used For Peptide Fractionationmentioning

confidence: 99%

Section: Enzymatic Membrane Reactor Equipped With Membranes: First Stmentioning

confidence: 99%

Section: Nf Transport Mechanismmentioning

confidence: 99%

Section: Nf Applied To Amino Acid and Peptide Fractionation: Reviewmentioning

confidence: 99%

See 2 more Smart Citations

Advancements in the Fractionation of Milk Biopeptides by Means of Membrane Processes

Muro¹,

Riera²,

Fernández³

2013

Bioactive Food Peptides in Health and Disease

View full text Add to dashboard Cite

“…Otherwise, the electrostatic effects would significantly influence the rejection properties due to the regained electrical properties of the amphoteric solute. The representative case is the separation and purification of amino acids and peptides [7,[42][43][44][45][46]. Since different amino acids have diverse isoelectric points, it is feasible to separate dissimilar amino acids with analogous MW.…”

Section: Applicationsmentioning

confidence: 99%

Modeling of the separation performance of nanofiltration membranes and its role in the applications of nanofiltration technology in product separation processes

Wang

Shang

Wang

2007

Front. Chem. Eng. China

View full text Add to dashboard Cite

the promising technologies for the separation of neutral and charged solutes in aqueous solutions [1,2]. It has two interesting features: one is the molecular weight cut-offs (MWCO) between reverse osmosis (RO) membranes and ultrafiltration (UF) membranes, which ranges from 200 to 2000 Da; the other is the separation of electrolytes due to the materials containing charged groups [1][2][3][4][5]. According to these two features and actual applications, NF can be considered as a membrane separation process between UF and RO [1,2]. As a "dense UF" membrane, the NF membrane has higher selectivity than the UF membrane when applied in many product separation processes, such as desalination and concentration [6], separation and purification [7,8]. As a "loose RO" membrane, the NF membrane can save more energy than the RO membrane when used in drinking water production and treatment [9,10] and re-use of municipal water [11,12]. The unique performances of the NF membrane may be ascribed to its size and charge effects. The structure of typical NF membranes was assumed to be a bundle of charged capillaries with structural parameters (the pore radius r p , the ratio of membrane porosity to membrane thickness A k /Dx) and electrical properties (such as the surface charge density q w ). As for the characterization of pore radius and pore size distribution, Nakao [3] once reviewed direct physical methods and indirect methods on the basis of the rejection performance using reference particles and a quantitative pore model or the so-called hydrodynamic model.Theories used to predict the separation performances of an NF membrane usually include: the non-equilibrium thermodynamic model, the pore model, the space charge model, the TMS model, the electrostatic and steric-hindrance model, and the semiempirical model [1,2,4,9]. For several years now, a lot of efforts have been devoted to developing models appropriate for the NF separation process and some good modeling work has been completed. However, some questions still exist, though it is clear that both sieve and electrostatic effects play a major role [13]. When one tries to model and Abstract Although there is a voluminous literature on the determination of structural parameters (the pore radius, the ratio of membrane porosity to membrane thickness) of a nanofiltration (NF) membrane and its separation performance (such as the rejection and the permeation flux) by the simplified Teorell-Meyer-Sievers (TMS) model, little of this research comments on other theories and the consequences of linking modeling evaluation to technological application. Theories used to predict the separation performance of an NF membrane usually include: the non-equilibrium thermodynamic model, the pore model, the space charge model, the TMS model, the electrostatic and steric-hindrance model, and the semiempirical model. In the article, we briefly trace the origins or the general ideas of the above-mentioned theories. From there, recent researches on the characterization of membrane structural parameters...

show abstract