Nanofibrous Bio‐inorganic Hybrid Structures Formed Through Self‐Assembly and Oriented Mineralization of Genetically Engineered Phage Nanofibers

He, Tao; Abbineni, Gopal; Cao, Binrui; Mao, Chuanbin

doi:10.1002/smll.201001108

Cited by 78 publications

(71 citation statements)

References 41 publications

(58 reference statements)

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“…Aggregation of rod or filamentous viral templates has been commonly observed in solutions of multivalent metal cations in which the concentration of positively charged metal ions is high enough to screen the negative surface charge of the virus, significantly reducing repulsive forces. 12,[24][25][26] Specifically, this electrostatically based behavior has been reported for the E3 M13 virus in solutions containing Cu 2þ , 20 Co 2þ , 27 and Ba 2þ (Ref. 28) ions.…”

Section: Resultsmentioning

confidence: 88%

Mineralization and optical characterization of copper oxide nanoparticles using a high aspect ratio bio-template

Zaman

Haberer

2014

Journal of Applied Physics

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Organized chains of copper oxide nanoparticles were synthesized, without palladium (Pd) activation, using the M13 filamentous virus as a biological template. The interaction of Cu precursor ions with the negatively charged viral coat proteins were studied with Fourier transform infrared spectroscopy, transmission electron microscopy, and energy dispersive x-ray spectroscopy. Discrete nanoparticles with an average diameter of 4.5 nm and narrow size distribution were closely spaced along the length of the high aspect ratio templates. The synthesized material was identified as a mixture of cubic Cu2O and monoclinic CuO. UV/Vis absorption measurements were completed and a direct optical band gap of 2.87 eV was determined using Tauc's method. This value was slightly larger than bulk, signaling quantum confinement effects within the templated materials.

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Section: Resultsmentioning

confidence: 88%

Mineralization and optical characterization of copper oxide nanoparticles using a high aspect ratio bio-template

Zaman

Haberer

2014

Journal of Applied Physics

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“…He’s group[135] proposed a new strategy based on self-assembly of M13 phage by using hydroxyapatite (HAP) as an inorganic precursor and the phage as a model bio-fiber. First, they displayed negatively charged E8 peptide on the pVIII protein to produce an anionic nanofiber, and then allowed cationic ions, such as Ca 2+ , to electrostatically interact with the nanofiber, and finally added anionic compounds such as PO 4 3− to produce nanofiber bundles that aggregated to form HAP-coated fibers.…”

Section: Hybrid Bacteriophage Based Nanomaterialsmentioning

confidence: 99%

Bacteriophages and phage-inspired nanocarriers for targeted delivery of therapeutic cargos

Karimi

Mirshekari

Basri

et al. 2016

Advanced Drug Delivery Reviews

148

108

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The main goal of drug delivery systems is to target therapeutic cargoes to desired cells and to ensure their efficient uptake. Recently a number of studies have focused on designing bio-inspired nanocarriers, such as bacteriophages, and synthetic carriers based on the bacteriophage structure Bacteriophages are viruses that specifically recognize their bacterial hosts. They can replicate only inside their host cell and can act as natural gene carriers. Each type of phage has a particular shape, a different capacity for loading cargo, a specific production time, and their own mechanisms of supramolecular assembly, that have enabled them to act as tunable carriers. New phage-based technologies have led to the construction of different peptide libraries, and recognition abilities provided by novel targeting ligands. Phage hybridization with non-organic compounds introduces new properties to phages and could be a suitable strategy for construction of bio-inorganic carriers. In this review we try to cover the major phage species that have been used in drug and gene delivery systems, and the biological application of phages as novel targeting ligands and targeted therapeutics.

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“…Genetic information could be transferred to next generations when there were conditions that are more favorable. HAp nanostructures have also been prepared using phages as template [132,133]. Phages were reported to be able to develop novel nanostructures and biomaterials but also to provide advantages in biomedicine that include molecular targeting, gene delivery and tissue regeneration [134].…”

Section: Appl Sci 2017 7 60mentioning

confidence: 99%

Biodegradable and Biocompatible Systems Based on Hydroxyapatite Nanoparticles

et al. 2017

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Abstract:Composites of hydroxyapatite (HAp) are widely employed in biomedical applications due to their biocompatibility, bioactivity and osteoconductivity properties. In fact, the development of industrially scalable hybrids at low cost and high efficiency has a great impact, for example, on bone tissue engineering applications and even as drug delivery systems. New nanocomposites constituted by HAp nanoparticles and synthetic or natural polymers with biodegradable and biocompatible characteristics have constantly been developed and extensive works have been published concerning their applications. The present review is mainly focused on both the capability of HAp nanoparticles to encapsulate diverse compounds as well as the preparation methods of scaffolds incorporating HAp. Attention has also been paid to the recent developments on antimicrobial scaffolds, bioactive membranes, magnetic scaffolds, in vivo imaging systems, hydrogels and coatings that made use of HAp nanoparticles.

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Nanofibrous Bio‐inorganic Hybrid Structures Formed Through Self‐Assembly and Oriented Mineralization of Genetically Engineered Phage Nanofibers

Cited by 78 publications

References 41 publications

Mineralization and optical characterization of copper oxide nanoparticles using a high aspect ratio bio-template

Mineralization and optical characterization of copper oxide nanoparticles using a high aspect ratio bio-template

Bacteriophages and phage-inspired nanocarriers for targeted delivery of therapeutic cargos

Biodegradable and Biocompatible Systems Based on Hydroxyapatite Nanoparticles

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