Nanofibrillar cellulose wound dressing in skin graft donor site treatment

Hakkarainen, Tiina; Koivuniemi, Raili; Kosonen, Mika; Escobedo‐Lucea, Carmen; Sanz-García, Andrés; Vuola, Jyrki; Valtonen, Jussi; Tammela, Päivi; Mäkitie, Antti; Luukko, Kari; Yliperttula, Marjo; Kavola, Heli

doi:10.1016/j.jconrel.2016.07.053

Cited by 198 publications

(166 citation statements)

References 51 publications

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“…The possibility to create NFC‐based dressings for wound healing applications has been introduced and examined in a series of studies by ourselves and others, with promising results. However, to date, no work has addressed neither the hemocompatibility aspect of NFC‐based materials, nor the possibility of modifying these materials to obtain dressings that aid the first phase of wound healing—hemostasis.…”

Section: Introductionmentioning

confidence: 99%

Hemocompatibility of Ca²⁺‐Crosslinked Nanocellulose Hydrogels: Toward Efficient Management of Hemostasis

Basu

Hong

Ferraz

2017

Macromolecular Bioscience

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The present work investigates Ca -crosslinked nanofibrillated cellulose hydrogels as potential hemostatic wound dressings by studying core interactions between the materials and a central component of wounds and wound healing-the blood. Hydrogels of wood-derived anionic nanofibrillated cellulose (NFC) and NFC hydrogels that incorporate kaolin or collagen are studied in an in vitro whole blood model and with platelet-free plasma assays. The evaluation of thrombin and factor XIIa formation, platelet reduction, and the release of activated complement system proteins, shows that the NFC hydrogel efficiently triggered blood coagulation, with a rapid onset of clot formation, while displaying basal complement system activation. By using the NFC hydrogel as a carrier of kaolin, the onset of hemostasis is further boosted, while the NFC hydrogel containing collagen exhibits blood activating properties comparable to the anionic NFC hydrogel. The herein studied NFC hydrogels demonstrate great potential for being part of advanced wound healing dressings that can be tuned to target certain wounds (e.g., strongly hemorrhaging ones) or specific phases of the wound healing process for optimal wound management.

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Section: Introductionmentioning

confidence: 99%

Hemocompatibility of Ca²⁺‐Crosslinked Nanocellulose Hydrogels: Toward Efficient Management of Hemostasis

Basu

Hong

Ferraz

2017

Macromolecular Bioscience

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“…In this clinical study, the dressings were found to be highly biocompatible in the treatment of skin graft donor sites. According to preliminary comparison studies with SUPRATHEL, epithelialization rate was faster with nanofibrillar cellulose dressing . Recently, the bone healing tendency of a nanocomposite (DBSint) constituted of biomimetic nanostructured Mg‐hydroxyapatite and human demineralized bone matrix was approved for clinical use.…”

Section: Human Studies or Clinical Trials Of Nanostructures For Diffementioning

confidence: 99%

“…According to preliminary comparison studies with SUPRATHEL, epithelialization rate was faster with nanofibrillar cellulose dressing. 158 Recently, the bone healing tendency of a nanocomposite (DBSint) constituted of biomimetic nanostructured Mg-hydroxyapatite and human demineralized bone matrix was approved for clinical use. The clinicalradiographic and histomorphometric analysis in subjects undergoing high tibial osteotomy validated the safe and effective usage of these nanocomposites.…”

Section: Human Studies or Clinical Trials Of Nanostructures For Diffementioning

confidence: 99%

Nanomaterials as potential and versatile platform for next generation tissue engineering applications

et al. 2019

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Tissue engineering (TE) is an emerging field where alternate/artificial tissues or organ substitutes are implanted to mimic the functionality of damaged or injured tissues. Earlier efforts were made to develop natural, synthetic, or semisynthetic materials for skin equivalents to treat burns or skin wounds. Nowadays, many more tissues like bone, cardiac, cartilage, heart, liver, cornea, blood vessels, and so forth are being engineered using 3‐D biomaterial constructs or scaffolds that could deliver active molecules such as peptides or growth factors. Nanomaterials (NMs) due to their unique mechanical, electrical, and optical properties possess significant opportunities in TE applications. Traditional TE scaffolds were based on hydrolytically degradable macroporous materials, whereas current approaches emphasize on controlling cell behaviors and tissue formation by nano‐scale topography that closely mimics the natural extracellular matrix. This review article gives a comprehensive outlook of different organ specific NMs which are being used for diversified TE applications. Varieties of NMs are known to serve as biological alternatives to repair or replace a portion or whole of the nonfunctional or damaged tissue. NMs may promote greater amounts of specific interactions stimulated at the cellular level, ultimately leading to more efficient new tissue formation. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2433–2449, 2019.

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“…The optimal wound dressing is still under debate, with no international consensus [13]. For instance, mesh gauzes based on paraffin, synthetic dressings imitating the natural epithelium (Suprathel; Polymedics Innovations Inc., Woodstock, GA, USA) [14], or nanofibrillar cellulose wound dressings [15] enhance STSG donor site healing. Of interest, the latter exhibits a renewable nature, good biocompatibility, and excellent physical properties, and may be a promising candidate for clinical application.…”

Section: Vascularization In Skin Reconstructionmentioning

confidence: 99%

The Crucial Role of Vascularization and Lymphangiogenesis in Skin Reconstruction

et al. 2018

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Background: The treatment of extensive skin defects and bradytrophic wounds remains a challenge in clinical practice. Despite emerging tissue engineering approaches, skin grafts and dermal substitutes are still the routine procedure for the majority of skin defects. Here, we review the role of vascularization and lymphangiogenesis for skin grafting and dermal substitutes from the clinician’s perspective. Summary: Graft revascularization is a dynamic combination of inosculation, angiogenesis, and vasculogenesis. The majority of a graft’s microvasculature regresses and is replaced by ingrowing microvessels from the wound bed, finally resulting in a chimeric microvascular network. After inosculation within 48–72 h, the graft is re-oxygenated. In contrast to skin grafts, the vascularization of dermal substitutes is slow and dependent on the ingrowth of vessel-forming angiogenic cells. Preclinical angiogenic strategies with adipose tissue-derived isolates are appealing for the treatment of difficult wounds and may markedly accelerate skin reconstruction in the future. However, their translation from bench to bedside is still restricted by major regulatory restrictions. Finally, the lymphatic system contributes to edema reduction and the removal of local wound debris. Therapeutic lymphangiogenesis is an emerging field of research in skin reconstruction. Key Messages: For the successful engraftment of skin grafts and dermal substitutes, the rapid formation of a microvascular network is of pivotal importance. Hence, to understand the biological processes behind revascularization of skin substitutes and to implement this knowledge into clinical practice is a prerequisite when treating skin defects. Furthermore, a functional lymphatic drainage crucially contributes to the engraftment of skin substitutes.

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Nanofibrillar cellulose wound dressing in skin graft donor site treatment

Abstract: Based on the preliminary clinical data, NFC dressing seems to be promising for skin graft donor site treatment since it is biocompatible, attaches easily to wound bed, and remains in place until donor site has renewed. It also detaches from the epithelialized skin by itself.

Cited by 198 publications

References 51 publications

Hemocompatibility of Ca²⁺‐Crosslinked Nanocellulose Hydrogels: Toward Efficient Management of Hemostasis

Hemocompatibility of Ca²⁺‐Crosslinked Nanocellulose Hydrogels: Toward Efficient Management of Hemostasis

Nanomaterials as potential and versatile platform for next generation tissue engineering applications

The Crucial Role of Vascularization and Lymphangiogenesis in Skin Reconstruction

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Nanofibrillar cellulose wound dressing in skin graft donor site treatment

Abstract: Based on the preliminary clinical data, NFC dressing seems to be promising for skin graft donor site treatment since it is biocompatible, attaches easily to wound bed, and remains in place until donor site has renewed. It also detaches from the epithelialized skin by itself.

Cited by 198 publications

References 51 publications

Hemocompatibility of Ca2+‐Crosslinked Nanocellulose Hydrogels: Toward Efficient Management of Hemostasis

Hemocompatibility of Ca2+‐Crosslinked Nanocellulose Hydrogels: Toward Efficient Management of Hemostasis

Nanomaterials as potential and versatile platform for next generation tissue engineering applications

The Crucial Role of Vascularization and Lymphangiogenesis in Skin Reconstruction

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Product

Resources

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Hemocompatibility of Ca²⁺‐Crosslinked Nanocellulose Hydrogels: Toward Efficient Management of Hemostasis

Hemocompatibility of Ca²⁺‐Crosslinked Nanocellulose Hydrogels: Toward Efficient Management of Hemostasis