Nanofibers and hydrogel hybrid system with synergistic effect of anti-inflammatory and vascularization for wound healing

Jin, Lin; Ma, Yanfei; Wang, Ruiya; Zhao, Shuo; Ren, Zhishuai; Ma, Shengnan; Shi, Yupeng; Hu, Bin; Guo, Yuqi

doi:10.1016/j.mtadv.2022.100224

Cited by 20 publications

(10 citation statements)

References 31 publications

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“…Besides hydrogel, nanofiber has shown promising performance as a biomaterial for skin regeneration and other applications [42,43] . Jin and coworkers recognize this potential and combine the advantages of nanofibers and hydrogel in their double structure NIR responsive system [44] . The nanofibrous skeleton provides growth factors for vascularization and excellent NIR response, and factors in the hydrogel produce anti‐inflammatory factors, respectively.…”

Section: Stimuli‐responsive Hydrogel Dressings For Wound Healingmentioning

confidence: 99%

“…[42,43] Jin and coworkers recognize this potential and combine the advantages of nanofibers and hydrogel in their double structure NIR responsive system. [44] The nanofibrous skeleton provides growth factors for vascularization and excellent NIR response, and factors in the hydrogel produce anti-inflammatory factors, respectively. Mxene, a class of 2D-transition metal material, was chosen as the nanofiber due to its high photothermal conversion efficiency.…”

Section: Photoresponsive Wound Dressingmentioning

confidence: 99%

“…� Promote wound closure, formation of new epithelial tissue. [44] NIR MXene nanofibers loaded with vascular endothelial growth factor and dopaminehyaluronic acid hydrogel loaded with diallyl trisulfide Acute wound � Proliferate skin cells and facilitate the wound healing. � Prevent excessive neovascularization and extracellular matrix deposition at the wound sites.…”

Section: Photothermal Therapy (Ptt)mentioning

confidence: 99%

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Responsive hydrogel dressings for intelligent wound management

Wang

Yeo

et al. 2023

BMEMat

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Due to global aging problems, the rising number of patients suffering from chronic or hard‐to‐heal acute wounds imposes a significant burden on healthcare systems. Wound healing is a complicated and dynamic physiological process with distinct molecular and cellular levels at each phase. Despite numerous strategies and advanced wound dressings being developed, successful wound management through smart dressing materials that can adapt to changing wound microenvironments and address the needs of wounds at different stages remains a big challenge. Over the last decade, hydrogel‐based dressings have emerged as one of the most potent biomaterials for wound treatment with favorable biological characteristics and a high potential for active intervention during the wound‐curing process. In the current contribution, we present the most recent progress in smart hydrogel dressings that can regulate the release of therapeutics in response to external stimuli (such as light) as well as endogenous changes in wound environments (e.g., temperature, pH, glucose, and reactive oxygen species) to facilitate wound healing. We also introduce the cutting‐edge technologies of intelligent “sense‐and‐treat” dressings through a combination of built‐in sensors or sensing molecules with responsive hydrogels, which enable real‐time monitoring of wound conditions and prompt on‐demand therapy.

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Section: Stimuli‐responsive Hydrogel Dressings For Wound Healingmentioning

confidence: 99%

Section: Photoresponsive Wound Dressingmentioning

confidence: 99%

Section: Photothermal Therapy (Ptt)mentioning

confidence: 99%

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Responsive hydrogel dressings for intelligent wound management

Wang

Yeo

et al. 2023

BMEMat

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“…1,2 In terms of wound closure methods, staples, 3 sutures, 4,5 bandages, adhesives strips, 6 hydrogels, 7 and nanofibers can all be considered, each having their advantages and disadvantages. 8,9 For example, suturing non-linear wounds require special expertise, and the outcome is largely determined by the surgeon's expertise. It is still possible to get an infection despite the sutures' sterility since the spaces allow bacteria to colonize.…”

Section: Introductionmentioning

confidence: 99%

Design of biocompatible polylactic acid–polyethylene glycol combination for manufacturing biodegradable staplers

Bakhtiary,

Bagheri,

Salehnia

2023

J of Applied Polymer Sci

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For the development of an effective and faster wound closure method, it is necessary to overcome current techniques' limitations. As compared to other methods, biodegradable staples provide superior mechanical properties, reduce scarring, and promote healing faster. Here, polylactic acid (PLA) and polyethylene glycol (PEG) composite staplers produced by solvent casting are presented as a suggestion for rapidly and easily closing wounds. The resulting samples were tested for mechanical properties, contact angle, and degradation properties over 21–90 days in the engineering phase. Selected formulations were moved to the biological phase for in vitro cytotoxicity by MTT assay and the in vivo biocompatibility assessment by transplantation of the samples into rats' back muscle. The tissue samples were collected and evaluated using hematoxylin and eosin and trichrome staining 1, 6, and 12 weeks after transplantation. When considering the maximum force tolerance range for PLA–PEG at around 20–58 N and comparing it with comparable commercial products, as well as their degradation rate and hydrophilicity, it was concluded that this combination maintains wound edges together. Cell viability tests demonstrated no cytotoxicity in the samples after 48 and 72 h. Morphological observations indicated some condensations of collagen fibers and no remarkable infiltration of inflammatory cells around the transplanted samples. In conclusion, the combination of PLA and PEG showed suitable mechanical properties, superior hydrophilicity, high biocompatibility and is suitable for medical staplers, and is innovative.

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“…Development of bioplatforms for drug delivery based on the combination of micro/nanofibers and hydrogels with both components playing an active role in the release is becoming a topic of growing interest by different reasons. − Due to their capability to absorb large amounts of water and their biomechanical similarity to an extracellular matrix (ECM), hydrogels have been chosen to produce tissue engineering scaffolds or as injectable delivery systems. − Furthermore, the open structure of hydrogels, in combination with the hydrophilic nature of the constituent polymer, facilitate the diffusion and fast release (from a few hours to a few days) of previously loaded hydrophilic drugs, ,, including lactate . In contrast, fibers made of biodegradable hydrophobic polymers present a compact structure and exceptionally high surface area, which not only favors cell cardiac performance but also allows a sustained drug release when they act as carriers, regardless of the hydrophilic or hydrophobic nature of the drug. − In fact, the release of drugs from such types of fibers is usually controlled by the degradation of the polymer.…”

Section: Introductionmentioning

confidence: 99%

Enzymatic Degradation of Polylactic Acid Fibers Supported on a Hydrogel for Sustained Release of Lactate

Colombi,

Macor,

Ortiz-Membrado

et al. 2023

ACS Appl. Bio Mater.

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The incorporation of exogenous lactate into cardiac tissues is a regenerative strategy that is rapidly gaining attention. In this work, two polymeric platforms were designed to achieve a sustained release of lactate, combining immediate and prolonged release profiles. Both platforms contained electrospun poly(lactic acid) (PLA) fibers and an alginate (Alg) hydrogel. In the first platform, named L/K(x)/Alg-PLA, lactate and proteinase K (x mg of enzyme per 1 g of PLA) were directly loaded into the Alg hydrogel, into which PLA fibers were assembled. In the second platform, L/Alg-K(x)/PLA, fibers were produced by electrospinning a proteinase K:PLA solution and, subsequently, assembled within the lactate-loaded hydrogel. After characterizing the chemical, morphological, and mechanical properties of the systems, as well as their cytotoxicity, the release profiles of the two platforms were determined considering different amounts of proteinase K (x = 5.2, 26, and 52 mg of proteinase K per 1 g of PLA), which is known to exhibit a broad cleavage activity. The profiles obtained using L/Alg-K(x)/PLA platforms with x = 26 and 52 were the closest to the criteria that must be met for cardiac tissue regeneration. Finally, the amount of lactate directly loaded in the Alg hydrogel for immediate release and the amount of protein in the electrospinning solution were adapted to achieve a constant lactate release of around 6 mM per day over 1 or 2 weeks. In the optimized bioplatform, in which 6 mM lactate was loaded in the hydrogel, the amount of fibers was increased by a factor of ×3, the amount of enzyme was adjusted to 40 mg per 1 g of PLA, and a daily lactate release of 5.9 ± 2.7 mM over a period of 11 days was achieved. Accordingly, the engineered device fully satisfied the characteristics and requirements for heart tissue regeneration.

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Nanofibers and hydrogel hybrid system with synergistic effect of anti-inflammatory and vascularization for wound healing

Cited by 20 publications

References 31 publications

Responsive hydrogel dressings for intelligent wound management

Responsive hydrogel dressings for intelligent wound management

Design of biocompatible polylactic acid–polyethylene glycol combination for manufacturing biodegradable staplers

Enzymatic Degradation of Polylactic Acid Fibers Supported on a Hydrogel for Sustained Release of Lactate

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