Nanofiberous coating for Bare Metal Stents: A comparative study of coaxial and monoaxial modes

Aditya, G.; Parmeshwar, D.; Mukty, S.

doi:10.1016/j.matpr.2019.06.570

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…As seen in all the micrographs, there is porosity throughout the stents due to solvent evaporation. The observed porosity depends on the mechanism of solvent evaporation during the drying process [ 59 ]. Fouladian et al (2021) mentioned that cavities appear during solvent evaporation due to water condensation as the surface cools, leading to respiration and the formation of defined structures on the surface [ 31 ].…”

Section: Resultsmentioning

confidence: 99%

A Study of PLA Thin Film on SS 316L Coronary Stents Using a Dip Coating Technique

Macías-Naranjo,

Sánchez-Domínguez,

Rubio-Valle

et al. 2024

Polymers

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The dip coating process is one of the recognized techniques used to generate polymeric coatings on stents in an easy and low-cost way. However, there is a lack of information about the influence of the process parameters of this technique on complex geometries such as stents. This paper studies the dip coating process parameters used to provide a uniform coating of PLA with a 4–10 µm thickness. A stainless-steel tube (AISI 316L) was laser-cut, electropolished, and dip-coated in a polylactic acid (PLA) solution whilst changing the process parameters. The samples were characterized to examine the coating’s uniformity, thickness, surface roughness, weight, and chemical composition. FTIR and Raman investigations indicated the presence of PLA on the stent’s surface, the chemical stability of PLA during the coating process, and the absence of residual chloroform in the coatings. Additionally, the water contact angle was measured to determine the hydrophilicity of the coating. Our results indicate that, when using entry and withdrawal speeds of 500 mm min−1 and a 15 s immersion time, a uniform coating thickness was achieved throughout the tube and in the stent with an average thickness of 7.8 µm.

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Section: Resultsmentioning

confidence: 99%

A Study of PLA Thin Film on SS 316L Coronary Stents Using a Dip Coating Technique

Macías-Naranjo,

Sánchez-Domínguez,

Rubio-Valle

et al. 2024

Polymers

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“…Adequate coating techniques are essential to acquire excellent drug loading and releasing. Dipping, spray, electrospunning nanofiber 298 as well as hydrogel 299 , 300 coating have been developed. Nevertheless, increasing researchers held the view that polymer coating could answer for SMC proliferation, endothelial incompetence, proinflammatory responses, and thrombotic events.…”

Section: Strategies Of Lesion-localizing Delivery For Treating Athero...mentioning

confidence: 99%

Recent advance in treatment of atherosclerosis: Key targets and plaque-positioned delivery strategies

Liu

Tan

et al. 2022

J Tissue Eng

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Atherosclerosis, a chronic inflammatory disease of vascular wall, is a progressive pathophysiological process with lipids oxidation/depositing initiation and innate/adaptive immune responses. The coordination of multi systems covering oxidative stress, dysfunctional endothelium, diseased lipid uptake, cell apoptosis, thrombotic and pro-inflammatory responding as well as switched SMCs contributes to plaque growth. In this circumstance, inevitably, targeting these processes is considered to be effective for treating atherosclerosis. Arriving, retention and working of payload candidates mediated by targets in lesion direct ultimate therapeutic outcomes. Accumulating a series of scientific studies and clinical practice in the past decades, lesion homing delivery strategies including stent/balloon/nanoparticle-based transportation worked as the potent promotor to ensure a therapeutic effect. The objective of this review is to achieve a very brief summary about the effective therapeutic methods cooperating specifical targets and positioning-delivery strategies in atherosclerosis for better outcomes.

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“…102 As shown in Table 3, the DREAMS-1 and Magmaris (DREAMS-2G) stents produced by Biotronik reported target lesion failure (TLF) and target lesion revascularization (TLR) values of 6.8% and 4.3%, respectively. 103 The strut thickness/ width was 150 μm for both designs with diameter values of 3 and 3.5 mm, respectively, and they were 15, 20, or 25 mm in length. Additionally, the drug paclitaxel, frequently used in second-generation DES designs, was functionalized on the surface through a thin (7 μm) PLLA film.…”

Section: Current Status Of Drug-eluting Stentsmentioning

confidence: 99%

Drug-Eluting, Bioresorbable Cardiovascular Stents─Challenges and Perspectives

Vallejo-Zamora

Vega-Cantú

Rodrı́guez

et al. 2022

ACS Appl. Bio Mater.

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Globally, the leading causes of natural death are attributed to coronary heart disease and type 1 and type 2 diabetes. High blood pressure levels, high cholesterol levels, smoking, and poor eating habits lead to the agglomeration of plaque in the arteries, reducing the blood flow. The implantation of devices used to unclog vessels, known as stents, sometimes results in a lack of irrigation due to the excessive proliferation of endothelial tissue within the blood vessels and is known as restenosis. The use of drug-eluting stents (DESs) to deliver antiproliferative drugs has led to the development of different encapsulation techniques. However, due to the potency of the drugs used in the initial stent designs, a chronic inflammatory reaction of the arterial wall known as thrombosis can cause a myocardial infarction (MI). One of the most promising drugs to reduce this risk is everolimus, which can be encapsulated in lipid systems for controlled release directly into the artery. This review aims to discuss the current status of stent design, fabrication, and functionalization. Variables such as the mechanical properties, metals and their alloys, drug encapsulation and controlled elution, and stent degradation are also addressed. Additionally, this review covers the use of polymeric surface coatings on stents and the recent advances in layer-by-layer coating and drug delivery. The advances in nanoencapsulation techniques such as liposomes and micro- and nanoemulsions and their functionalization in bioresorbable, drug-eluting stents are also highlighted.

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Nanofiberous coating for Bare Metal Stents: A comparative study of coaxial and monoaxial modes

Cited by 5 publications

References 17 publications

A Study of PLA Thin Film on SS 316L Coronary Stents Using a Dip Coating Technique

A Study of PLA Thin Film on SS 316L Coronary Stents Using a Dip Coating Technique

Recent advance in treatment of atherosclerosis: Key targets and plaque-positioned delivery strategies

Drug-Eluting, Bioresorbable Cardiovascular Stents─Challenges and Perspectives

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