Nanofiber scaffolds facilitate functional regeneration of peripheral nerve injury

Zhan, Xiaoduo; Gao, Mingyong; Jiang, Yanwen; Zhang, Weiwei; Wong, Wai Man; Yuan, Qiuju; Su, Huanxing; Kang, Xiaoning; Dai, Xiujuan J.; Zhang, Wenying; Guo, Jiasong; Wu, Wutian

doi:10.1016/j.nano.2012.08.009

Cited by 83 publications

(52 citation statements)

References 27 publications

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“…Highlighted, nerve guidance conduits are inspired to create a stable structural bridge between nerve gaps while promoting cellular growth and initiating electrical stimulation [adapted with permission from Daly et al (2012)]. Bottom-Left: representative image of the implantation (a) and post-16 weeks (b) of a nerve conduit for sciatic nerve repair in rats followed by the increase in axon growth across the conduit dimensions [adapted with permission from Zhan et al (2013)]. Bottom-Right: example of the incorporation of nanohybrid materials (gold nanoparticle-silk-fibroin nanotiber.Ai GNP-SF) for peripheral nerve regeneration.…”

Section: A Gap Bridged By Nanomaterials For Peripheral and Central Nementioning

confidence: 99%

“…In a study by Zhan and colleagues, a self-assembly peptide nanofiber scaffold (SAPNS) with an artery conduit sheath was implanted on the proximal and distal nerve stumps to bridge a 10 mm gap in adult rats (Zhan et al, 2013). It was found that after 16 weeks, the artificial nerve graft promoted myelination, satellite cell migration, and axonal growth over the conduit.…”

Section: A Gap Bridged By Nanomaterials For Peripheral and Central Nementioning

confidence: 99%

“…It was found that after 16 weeks, the artificial nerve graft promoted myelination, satellite cell migration, and axonal growth over the conduit. In addition, assessment of the injured hindlimb motor function displayed significant improvement just after 6 weeks and followed throughout the 15-week period (Zhan et al, 2013). SAPNS have been of interest for axon regeneration over the last decade, initiated by Ellis-Behnke and colleagues (Ellis-Behnke et al, 2006, 2009.…”

Section: A Gap Bridged By Nanomaterials For Peripheral and Central Nementioning

confidence: 99%

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Nano-Engineered Biomaterials for Tissue Regeneration: What Has Been Achieved So Far?

et al. 2016

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Nanomaterials have attracted the interest of tissue engineers for the last two decades. Their unique properties make them promising for de novo fabrication of bio-inspired hybrid/composite materials with improved regenerative properties, including, for example, the capacity for electric conductivity and the provision of antimicrobial properties. However, to this day, the use of such materials in medical applications is rather limited and most of the studies have only reached the archetypical proof-of-concept stage. Herein, we present a review on the use of nanomaterials in tissue engineering for regenerative therapies of heart, skin, eye, skeletal muscle, and nervous system. The advantages and limitations of nano-engineering materials are presented in this review alongside with the future challenges and milestones nanotechnology must overcome to make an impact in biomedical applications.

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Section: A Gap Bridged By Nanomaterials For Peripheral and Central Nementioning

confidence: 99%

Section: A Gap Bridged By Nanomaterials For Peripheral and Central Nementioning

confidence: 99%

Section: A Gap Bridged By Nanomaterials For Peripheral and Central Nementioning

confidence: 99%

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Nano-Engineered Biomaterials for Tissue Regeneration: What Has Been Achieved So Far?

et al. 2016

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“…Nanofibers, particularly self-assembly peptide nanofibers, are effective scaffolds in neural bioengineering with attractive properties such as interfacial compatibility and bioadhesive properties [127][128][129][130]. Nanofibers have unique properties beneficial to nerve regeneration, including a biomimic native extracellular matrix that supports cell adherence, migration and proliferation [128,[130][131][132], platforms to stimulate regrowth of damaged tissues [128,131], the ability to facilitate the delivery of drugs, neural growth factors and neuroprotective agents to the injury site [128,132,133] and excellent biocompatibility and biodegradability [128,131,133]. A novel technology using tiny nanofibers had favorable results for helping the body repair and restore damaged tissues caused by injury or disease, including brain trauma [132,133].…”

Section: Nerve Regenerationmentioning

confidence: 99%

“…Electropun nanofibers have also been studied for nerve regeneration [130,135]. The biological performance of the conduits was examined in a rat sciatic nerve model with a 10-mm gap length.…”

Section: Nerve Regenerationmentioning

confidence: 99%

Nanofibers Used for the Delivery of Analgesics

Tseng

Liu²

2015

Nanomedicine (Lond.)

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Nanofibers are extremely advantageous for drug delivery because of their high surface area-to-volume ratios, high porosities and 3D open porous structures. Local delivery of analgesics by using nanofibers allows site-specificity and requires a lower overall drug dosage with lower adverse side effects. Different analgesics have been loaded onto various nanofibers, including those that are natural, synthetic and copolymer, for various medical applications. Analgesics can also be singly or coaxially loaded onto nanofibers to enhance clinical applications. In particular, analgesic-eluting nanofibers provide additional benefits to preventing wound adhesion and scar formation. This paper reviews current research and breakthrough discoveries on the innovative application of analgesic-loaded nanofibers that will alter the clinical therapy of pain.

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Biomedical Applications of Nanofibers

2007

Science and Technology of Polymer Nanofibers

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The idea of creating replacement for damaged or diseased tissue, which will mimic the physiological conditions and simultaneously promote regeneration by patients' own cells, has been a major challenge in the biomedicine for more than a decade. Therefore, nanofi bers are a promising solution to address these challenges. Nanofi ber technology is an exciting area attracting the attention of many researchers as a potential solution to these current challenges in the biomedical fi eld such as burn and wound care, organ repair, and treatment for osteoporosis and various diseases. Nanofi bers mimic the porous topography of natural extracellular matrix (ECM), hence they are advantageous for tissue regeneration . In biomedical engineering, electrospinning exhibits advantages as a tissue engineering scaff olds producer, which can make appropriate resemblance in physical structure with ECM. This is because of the nanometer scale of ECM fi brils in diameter, which can be mimicked by electrospinning procedure as well as its porous structure. In this review, the applications of nanofi bers in various biomedical areas such as tissue engineering, wound dressing and facemask, are summarized. It provides opportunities to develop new materials and techniques that improve the ability for developing quick, sensitive and reliable analytical techniques.

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Nanofiber scaffolds facilitate functional regeneration of peripheral nerve injury

Cited by 83 publications

References 27 publications

Nano-Engineered Biomaterials for Tissue Regeneration: What Has Been Achieved So Far?

Nano-Engineered Biomaterials for Tissue Regeneration: What Has Been Achieved So Far?

Nanofibers Used for the Delivery of Analgesics

Biomedical Applications of Nanofibers

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