Nanofiber-reinforced bulk hydrogel: preparation and structural, mechanical, and biological properties

Huang, Yu Tien; Li, Xiufang; Lu, Zhentan; Zhang, Huan; Huang, Jiangxi; Yan, Kun; Wang, Dong

doi:10.1039/d0tb01948h

Cited by 50 publications

(21 citation statements)

References 25 publications

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“…It is reasonable to consider that aqueous medium immersion and drying post-treatment may reduce the bonding force between ceramic grains, which may account for the strength decay. Nonetheless, the mechanical strength provided by the static electrostatic interaction of the Biogel was negligible compared with the compressive strength of pure bioceramic scaffolds . Despite the instant decreased mechanical strength, during the process of biodissolution, the CSi-M10/Biogel can still outperform the pure bioceramic material for long-term structural stability (Figure B, C, and E).…”

Section: Resultsmentioning

confidence: 99%

Precisely Tuning the Pore-Wall Surface Composition of Bioceramic Scaffolds Facilitates Angiogenesis and Orbital Bone Defect Repair

Peng

Wang

Dai

et al. 2022

ACS Appl. Mater. Interfaces

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Orbital bone damage (OBD) may result in severe post-traumatic enophthalmos, craniomaxillofacial deformities, vision loss, and intracranial infections. However, it is still a challenge to fabricate advanced biomaterials that can match the individual anatomical structure and enhance OBD repair in situ. Herein, we aimed to develop a selective surface modification strategy on bioceramic scaffolds and evaluated the effects of inorganic or organic functional coating on angiogenesis and osteogenesis, ectopically and orthotopically in OBD models. It was shown that the low thermal bioactive glass (BG) modification or layer-by-layer assembly of a biomimetic hydrogel (Biogel) could readily integrate into the pore wall of the bioceramic scaffolds. The BG and Biogel modification showed appreciable enhancement in the initial compressive strength (∼30−75%) or structural stability in vivo, respectively. BG modification could enhance by nearly 2-fold the vessel ingrowth, and the osteogenic capacity was also accelerated, accompanied with a mild scaffold biodegradation after 3 months. Meanwhile, the Biogel-modified scaffolds showed enhanced osteogenic differentiation and mineralization through calcium and phosphorus retention. The potential mechanism of the enhanced bone repair was elucidated via vascular and osteogenic cell responses in vitro, and the cell tests indicated that the Biogel and BG functional layers were both beneficial for in vitro osteoblastic differentiation and mineralization on bioceramics. Totally, these findings demonstrated that the bioactive ions or biomolecules could significantly improve the angiogenic and osteogenic capabilities of conventional bioceramics, and the integration of inorganic or organic functional coating in the pore wall is a highly flexible material toolbox that can be tailored directly to improve orbital bone defect repair.

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Section: Resultsmentioning

confidence: 99%

Precisely Tuning the Pore-Wall Surface Composition of Bioceramic Scaffolds Facilitates Angiogenesis and Orbital Bone Defect Repair

Peng

Wang

Dai

et al. 2022

ACS Appl. Mater. Interfaces

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“…It was found that more cells adhered to the rough alginate hydrogel surfaces than to smooth surfaces. [ 49 , 50 ] The increase in surface roughness of MNPs/Alg hydrogels could promote the adhesion of CMs to hydrogels at the MI site and enhance repair effect.…”

Section: Resultsmentioning

confidence: 99%

Natural Melanin/Alginate Hydrogels Achieve Cardiac Repair through ROS Scavenging and Macrophage Polarization

et al. 2021

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The efficacy of cardiac regenerative strategies for myocardial infarction (MI) treatment is greatly limited by the cardiac microenvironment. The combination of reactive oxygen species (ROS) scavenging to suppress the oxidative stress damage and macrophage polarization to regenerative M2 phenotype in the MI microenvironment can be desirable for MI treatment. Herein, melanin nanoparticles (MNPs)/alginate (Alg) hydrogels composed of two marine-derived natural biomaterials, MNPs obtained from cuttlefish ink and alginate extracted from ocean algae, are proposed. Taking advantage of the antioxidant property of MNPs and mechanical support from injectable alginate hydrogels, the MNPs/Alg hydrogel is explored for cardiac repair by regulating the MI microenvironment. The MNPs/Alg hydrogel is found to eliminate ROS against oxidative stress injury of cardiomyocytes. More interestingly, the macrophage polarization to regenerative M2 macrophages can be greatly promoted in the presence of MNPs/Alg hydrogel. An MI rat model is utilized to evaluate the feasibility of the as-prepared MNPs/Alg hydrogel for cardiac repair in vivo. The antioxidant, anti-inflammatory, and proangiogenesis effects of the hydrogel are investigated in detail. The present study opens up a new way to utilize natural biomaterials for MI treatment and allows to rerecognize the great value of natural biomaterials in cardiac repair.

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“…Moreover, the favorable alkali swelling effect also contributes to improved tensile performance along the R -direction for the A-Wood- g -PAM hydrogel (Figure b). Specifically, the prepared A-Wood- g -PAM- n hydrogel has desirable tensile strength among the most strong hydrogels including the bacterial cellulose gel, , CNF gel, , PAM/CNF gel, double-network (DN) gel, , nanocomposite (NC) gel, , and so on, although the wood mass fraction is low (≈9%). FE-SEM images show that the A-Wood- g -PAM-15 hydrogel exhibits good compatibility between PAM and wood cell walls without any visible interface gaps (Figure f,g).…”

Section: Results and Discussionmentioning

confidence: 99%

“…Hydrogels are highly hydrated polymer networks that present similar “wet-and-soft” features to soft tissues and have attracted increasing attention in biological fields, such as artificial tissues, bioelectronics, and flexible sensors. , However, the scope of hydrogel applications is often severely limited by their weak mechanical behavior. , Although various approaches have been explored to overcome this problem by introducing double-network hydrogels, , physically and/or covalently hybrid cross-linked hydrogels, and nanofiber-reinforced polymer hydrogels, , most of these hydrogels cannot exhibit comparable mechanical properties that are similar to most of the human biological tissues (with the modulus and strength more than 10 MPa) . Specifically, soft tissues, such as muscles, tendons, and ligaments, can be categorized as biological hydrogels, which consist of highly oriented fibrous tissues and possess excellent strength and toughness along the fibrous direction in aqueous environments.…”

Section: Introductionmentioning

confidence: 99%

Toward Strong and Tough Wood-Based Hydrogels for Sensors

et al. 2021

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The purpose of this research is to develop strong and tough wood-based hydrogels, which are reinforced by an aligned cellulosic wood skeleton. The hypothesis is that improved interfacial interaction between the wood cell wall and a polymer is of great importance for improving the mechanical performance. To this end, a facile and green approach, called ultraviolet (UV) grafting, was performed on the polyacrylamide (PAM)-infiltrated wood skeleton without using initiators. An important finding was that PAM-grafted cellulose nanofiber (CNF) architectures formed in the obtained hydrogels under UV irradiation, where CNFs themselves serve as both initiators and cross-linkers. Moreover, an alkali swelling treatment was utilized to improve the accessibility of the wood cell wall before UV irradiation and thus facilitate grafting efficiency. The resulting alkali-treated Wood-g-PAM hydrogels exhibited significantly higher tensile properties than those of the Wood/PAM hydrogel and were further assembled into conductive devices for sensor applications. We believe that this UV grafting strategy may facilitate the development of strong wood-based composites with interesting features.

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Nanofiber-reinforced bulk hydrogel: preparation and structural, mechanical, and biological properties

Abstract: Alginate-based hydrogel were increasingly used as biomaterials, such as tissue engineering, drug carriers, wound dressing; however, the poor mechanical strength limited their applications. Nanofiber reinforcement was an effective method to...

Cited by 50 publications

References 25 publications

Precisely Tuning the Pore-Wall Surface Composition of Bioceramic Scaffolds Facilitates Angiogenesis and Orbital Bone Defect Repair

Precisely Tuning the Pore-Wall Surface Composition of Bioceramic Scaffolds Facilitates Angiogenesis and Orbital Bone Defect Repair

Natural Melanin/Alginate Hydrogels Achieve Cardiac Repair through ROS Scavenging and Macrophage Polarization

Toward Strong and Tough Wood-Based Hydrogels for Sensors

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