Nanoengineering a Biocompatible Inorganic Scaffold for Skin Wound Healing

Poinern, Gérrard Eddy Jai; Fawcett, Derek; Ng, Yuki J.; Ali, Nadire N.; Brundavanam, Ravi Krishna; Jiang, Zhong Tao

doi:10.1166/jbn.2010.1148

Cited by 37 publications

(29 citation statements)

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“…Recently, a special issue of Journal of Biomedical Nanotechnology (www.aspbs.com/jbn) solely focused on nanotechnology as it pertains to skin care has been published. [91][92][93][94][95][96][97][98][99][100][101][102][103][104][105][106] Nohynek et al 107 111 reported zinc oxide nanoparticles induced genotoxicity in primary human epidermal keratinocytes. The biological interactions of ZnO nanoparticles in primary human epidermal keratinocytes (HEK) were investigated by scanning electron microscopy.…”

Section: Cosmetics and Toxicity Of Nanoparticlesmentioning

confidence: 99%

Medical Applications of Nanoparticles in Biological Imaging, Cell Labeling, Antimicrobial Agents, and Anticancer Nanodrugs

Singh¹,

Nalwa²

2011

j biomed nanotechnol

281

131

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This article reviews the applications of nanotechnology in the fields of medical and life sciences. Nanoparticles have shown promising applications from diagnosis to treatment of various types of diseases including cancer. In this review, we discuss the applications of nanostructured materials such as nanoparticles, quantum dots, nanorods, nanowires, and carbon nanotubes in diagnostics, biomarkers, cell labeling, contrast agents for biological imaging, antimicrobial agents, drug delivery systems, and anticancer nanodrugs for treatment of cancer and other infectious diseases. The adverse affects of nanoparticles on human skin from daily use in cosmetics and general toxicology of nanoscale materials are also reviewed.

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Section: Cosmetics and Toxicity Of Nanoparticlesmentioning

confidence: 99%

Medical Applications of Nanoparticles in Biological Imaging, Cell Labeling, Antimicrobial Agents, and Anticancer Nanodrugs

Singh¹,

Nalwa²

2011

j biomed nanotechnol

281

131

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“…During the second step, a densely packed, highly ordered pore array is produced [5, 6]. It was this improved technique of fabricating nanometre scale structures in the oxide layer that rekindled interest in using anodic aluminium oxide (AAO) membranes as a potential template for the manufacture of nanometre scale materials [7, 8], biological/chemical sensors [9, 10], filter membranes, [11] and medical scaffolds for tissue engineering [12–14]. …”

Section: Introductionmentioning

confidence: 99%

Chemical Synthesis, Characterisation, and Biocompatibility of Nanometre Scale Porous Anodic Aluminium Oxide Membranes for Use as a Cell Culture Substrate for the Vero Cell Line: A Preliminary Study

Poinern

O’Dea

et al. 2014

BioMed Research International

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In this preliminary study we investigate for the first time the biomedical potential of using porous anodic aluminium oxide (AAO) membranes as a cell substrate for culturing the Cercopithecus aethiops (African green monkey) Kidney (Vero) epithelial cell line. One advantage of using the inorganic AAO membrane is the presence of nanometre scale pore channels that allow the exchange of molecules and nutrients across the membrane. The size of the pore channels can be preselected by adjusting the controlling parameters of a temperature controlled two-step anodization process. The cellular interaction and response of the Vero cell line with an in-house synthesised AAO membrane, a commercially available membrane, and a glass control were assessed by investigating cell adhesion, morphology, and proliferation over a 72 h period. The number of viable cells proliferating over the respective membrane surfaces revealed that the locally produced in-house AAO membrane had cells numbers similar to the glass control. The study revealed evidence of focal adhesion sites over the surface of the nanoporous membranes and the penetration of cellular extensions into the pore structure as well. The outcome of the study has revealed that nanometre scale porous AAO membranes have the potential to become practical cell culture scaffold substrates with the capability to enhance adhesion and proliferation of Vero cells.

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“…Nano-sized and nanoporous aluminum oxide can potentially have many biomedical applications, including the development of new medication to treat skin wound in the form of a saline suspension and as a component of wound dressings [1,2]. As found in [3], aluminum oxide nanoparticles can penetrate the epithelial barrier and accumulate in target organs such as brain, spleen, kidney, heart, and others.…”

Section: Introductionmentioning

confidence: 99%

Toxicity of the hybrid material based on low-dimensional structures of aluminum oxide

Бакина¹,

Глазкова²,

Svarovskaya³

et al. 2014

AIP Conference Proceedings

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Abstract. Aluminum oxides of various morphology and phase composition, including pseudoboehmite, have wide application in medicine. The novel hybrid material from polymer fibers and low-dimensional structures of pseudoboehmite fixed on them can be used as a wound dressing due to its highly absorbent and adsorbent properties. The in vivo investigation of acute and chronic toxicity of the novel hybrid material after a single dermal application in the acute experiment for 8 and 24 hours with outbred male and female rats reveals no irritation or other pathological changes. The chronic toxicity testing of the material after multiple dermal applications at two doses causes no death of animals and no pathological changes in their general condition, weight dynamics, and visceral morphology. The macro-and microscopy of internal organs shows no pathological changes as compared to control animals. The results obtained bear witness to the low potential risk of toxicity when using the hybrid material as a wound dressing.

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Nanoengineering a Biocompatible Inorganic Scaffold for Skin Wound Healing

Cited by 37 publications

References 0 publications

Medical Applications of Nanoparticles in Biological Imaging, Cell Labeling, Antimicrobial Agents, and Anticancer Nanodrugs

Medical Applications of Nanoparticles in Biological Imaging, Cell Labeling, Antimicrobial Agents, and Anticancer Nanodrugs

Chemical Synthesis, Characterisation, and Biocompatibility of Nanometre Scale Porous Anodic Aluminium Oxide Membranes for Use as a Cell Culture Substrate for the Vero Cell Line: A Preliminary Study

Toxicity of the hybrid material based on low-dimensional structures of aluminum oxide

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