Nanoengineered injectable hydrogels for wound healing application

Abstract

Hemorrhage is a leading cause of death in battlefield wounds, anastomosis hemorrhage and percutaneous intervention. Thus, there is a need for the development of novel bioactive materials to reduce the likelihood of hemorrhagic shock stemming from internal wounds. Here, we introduce an injectable hemostat from kappa-carrageenan and two-dimensional (2D) nanosilicates. Nanosilicates mechanically reinforce the hydrogels, provide enhanced physiological stability and accelerate the clotting time by two-fold. The sustained release of entrapped therapeutics due to presence of nanosilicates promotes enhanced wound healing. The multifunctional nanocomposite hydrogels could be used as an injectable hemostat for penetrating injury and percutaneous intervention during surgery.

Recent advances in shear‐thinning and self‐healing hydrogels for biomedical applications

“…This nanocomposite material has been shown to decrease in vitro blood clotting times by 77% and promote hemostasis in a liver laceration model [Figure (b)] . In order to enhance mechanical and bioactive properties of this system, a sulfated polysaccharide, kappa carrageenan (κCA) was used to form ionotropic and thermotropic gels that released therapeutics over a period of 21 days …”

Seaweeds as nutraceuticals for health and nutrition

“…The bioactive gauze fabric was recommended for use as a nonimplantable material in bandages, surgical masks and gowns, or as a multi-use hygienic textile. Lokhande et al (2018) used κ-carrageenan (κCA), to produce a haemostatic product, i.e. an agent that stops bleeding.…”

Printing Therapeutic Proteins in 3D using Nanoengineered Bioink to Control and Direct Cell Migration

“…Nanosilicate have a permanent negative surface charge on each face of the particle and a positive charge along the edges . This facilitate interactions of nanosilicates with a wide range of biomolecules including bone morphogenetic proteins 2, transforming growth factor beta 1, VEGF, platelet‐derived growth factor, and fibroblast growth factor (FGF), thus eliminating complex chemical modification . The high surface area and unique surface charge of nanosilicates can results in high‐efficiency binding ( ≈ 100%) and slow release of proteins for prolong duration (>3 weeks).…”

“…In addition, these nanosilicate‐based hydrogels can be used as vehicles for delivery of protein therapeutics due to charged characteristics. Nanosilicates can act as plug‐and‐play device to sequester a range of therapeutics for prolong delivery (>3 weeks) …”