Nanoencapsulation of quercetin enhances its dietary efficacy in combating arsenic-induced oxidative damage in liver and brain of rats

Nanoparticle transport across the blood brain barrier

“…Nanoencapsulated quercitin, orally administered before the arsenite injection, prevented the arsenic cerebral oxidative damage. 38 The authors hypothesized the ability of these NPs to cross the BBB via particle uptake mechanism based on an endocytotic pathway by the brain capillary endothelial cells. It is not clear if the treatment of rats with arsenic maintained the BBB integrity, thus it is difficult to give an absolute conclusion on the real efficacy and BBB crossing pathway.…”

Antioxidative Effect of Rice Bran Oil and Medium Chain Fatty Acid Rich Rice Bran Oil in Arsenite Induced Oxidative Stress in Rats

“…A number of studies have shown arsenic-induced formation of reactive oxygen and nitrogen species as well as elevated DNA oxidation. Thus, arsenite 12,13 .…”

Hepatoprotective and neuroprotective activity of liposomal quercetin in combating chronic arsenic induced oxidative damage in liver and brain of rats

“…Besides, it is widely accepted that the beneficial effects of quercetin against arsenic toxicity are mainly due to its antioxidant properties and also due to regulation of signalling pathway. The preventive role of quercetin encapsulated in nanoparticles against NaAsO 2 -induced acute liver and neuronal toxicity in rats has been shown in our previous work (Ghosh et al 2009) where a single oral dose of nanoformulation was found to be effective against acute arsenic toxicity. Inorganic arsenic when administered for a longer duration (chronic arsenic treatment) of time gets metabolized by a process involving a two-electron reduction of pentavalent arsenic to trivalent arsenic, exerting more oxidative pressure to cellular macromolecules.…”

“…Bioavailability of drugs can be improved when they are administered intravenously upon entrapment in liposomes (Gregoriadis et al 1988). Our previous report indicates that nanoencapsulation of drug enhances its dietary efficiency in combating arsenic-induced acute toxicity in liver and brain of rats (Ghosh et al 2009). …”

“…Quercetin, the most abundant bioflavonoid in nature, contains a number of phenolic hydroxyl groups and exhibits its therapeutic potential against many diseases, including ischemic heart diseases, liver fibrosis, renal injury, and chronic billiary obstruction (Peres et al 2000;Lee et al 2003;Singh et al 2004;Tokyol et al 2006). In our previous study (Ghosh et al, 2009), the preventive effect of a single oral dose of nanoencapsulated quercetin over arsenic-induced acute toxicity in liver and brain of adult female rats were studied. Therefore, it seems reasonable to expect that simultaneous multiple dose administration (s.c.) of quercetin encapsulated in liposomes might contribute to reduce chronic NaAsO 2 -induced oxidative damage in cellular and subcellular parts of hepatic and brain tissues and provide a protective mechanism against liver fibrosis as well as neurodegeneration.…”