Nanoencapsulation of lutein within lipid-based delivery systems: Characterization and comparison of zein peptide stabilized nano-emulsion, solid lipid nanoparticle, and nano-structured lipid carrier

Liu, Mengyao; Wang, Fuli; Pu, Chuanfen; Tang, Wenting; Sun, Qingjie

doi:10.1016/j.foodchem.2021.129840

Cited by 50 publications

(16 citation statements)

References 41 publications

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“…Its two key features are its good biocompatibility and self-assembly characteristics; therefore, zein is an ideal and safe raw material in food production [ 17 , 18 ] and medicines [ 19 , 20 ] and has attracted widespread attention. Nanoparticles (NPs) along with zein are used as carrier materials to enhance the stability and bioavailability of insoluble drugs [ 21 ]. However, zein is not an ideal nanocarrier material due to its low stability, burst release, and encapsulation efficiency [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

One-Pot Self-Assembly of Core-Shell Nanoparticles within Fibers by Coaxial Electrospinning for Intestine-Targeted Delivery of Curcumin

Hou

Zhang

et al. 2023

Foods

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Nanotechniques for curcumin (Cur) encapsulation provided a potential capability to avoid limitations and improve biological activities in food and pharmaceutics. Different from multi-step encapsulation systems, in this study, zein–curcumin (Z–Cur) core-shell nanoparticles could be self-assembled within Eudragit S100 (ES100) fibers through one-pot coaxial electrospinning with Cur at an encapsulation efficiency (EE) of 96% for ES100–zein–Cur (ES100–Z–Cur) and EE of 67% for self-assembled Z–Cur. The resulting structure realized the double protection of Cur by ES100 and zein, which provided both pH responsiveness and sustained release performances. The self-assembled Z–Cur nanoparticles released from fibermats were spherical (diameter 328 nm) and had a relatively uniform distribution (polydispersity index 0.62). The spherical structures of Z–Cur nanoparticles and Z–Cur nanoparticles loaded in ES100 fibermats could be observed by transmission electron microscopy (TEM). Fourier transform infrared spectra (FTIR) and X-ray diffractometer (XRD) revealed that hydrophobic interactions occurred between the encapsulated Cur and zein, while Cur was amorphous (rather than in crystalline form). Loading in the fibermat could significantly enhance the photothermal stability of Cur. This novel one-pot system much more easily and efficiently combined nanoparticles and fibers together, offering inherent advantages such as step economy, operational simplicity, and synthetic efficiency. These core-shell biopolymer fibermats which incorporate Cur can be applied in pharmaceutical products toward the goals of sustainable and controllable intestine-targeted drug delivery.

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Section: Introductionmentioning

confidence: 99%

One-Pot Self-Assembly of Core-Shell Nanoparticles within Fibers by Coaxial Electrospinning for Intestine-Targeted Delivery of Curcumin

Hou

Zhang

et al. 2023

Foods

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“…Polymeric nanoparticles have been investigated as a potential delivery system for lutein to areas such as the eye . Lipid-based carriers encapsulating lutein (nanoemulsion, solid lipid nanoparticle, and nanostructured lipid carriers) can also effectively increase absorption efficiency . Stevioside entrapment significantly promotes the bioavailability of lutein through multiple transmembrane pathways …”

Section: Application Of Luteinmentioning

confidence: 99%

Advances in Research on Natural Distribution, Biosynthesis, Detection, Bioactivity, and Application of Lutein

Zhao

Ci²,

Pang

et al. 2022

ACS Agric. Sci. Technol.

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Lutein, [(3R,3′R,6′R)-β,ε-carotene-3,3′-diol], is a C40 hydroxyl carotenoid. Its chemical structure is based on an unsaturated polyene chain skeleton, and there are one ε-ring and one β-ring on both sides of the skeleton, with a hydroxyl group on the 3′ site of each ring. Lutein is one of the important lipophilic isoprenes from mainly plants and algae. The wide range of sources makes the study of lutein quite comprehensive. The biosynthetic pathway and biochemical activities of lutein have been extensively studied and revealed. Lutein has been extensively studied for its important bioactivity, including for use in functional foods and medicines for brain health, eye-related diseases, skin health, and cancers. This review of lutein summarizes the major studies on bioactivity, metabolism, stability, digestive absorption, lutein delivery systems, and biotechnology.

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“…The critical parameters for the preparation of emulsions mainly include the average particle size, physical and chemical stabilities, and biological activities. The stabilities of particle size and lutein in emulsions are related to encapsulation modes [ 11 ], preparation methods, components of oil and emulsifier [ 12 , 13 ], temperature, pH and other conditions in preparation, and kinds and concentrations of antioxidants [ 14 ]. Antioxidants can improve the physical and chemical stability of bioactive products in emulsions.…”

Section: Introductionmentioning

confidence: 99%

Enhancing the stability of lutein emulsions with a water-soluble antioxidant and a oil-soluble antioxidant

Wang¹,

Zhang²,

Yan³

et al. 2023

Heliyon

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Nanoencapsulation of lutein within lipid-based delivery systems: Characterization and comparison of zein peptide stabilized nano-emulsion, solid lipid nanoparticle, and nano-structured lipid carrier

Cited by 50 publications

References 41 publications

One-Pot Self-Assembly of Core-Shell Nanoparticles within Fibers by Coaxial Electrospinning for Intestine-Targeted Delivery of Curcumin

One-Pot Self-Assembly of Core-Shell Nanoparticles within Fibers by Coaxial Electrospinning for Intestine-Targeted Delivery of Curcumin

Advances in Research on Natural Distribution, Biosynthesis, Detection, Bioactivity, and Application of Lutein

Enhancing the stability of lutein emulsions with a water-soluble antioxidant and a oil-soluble antioxidant

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