Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin: A review of new trends and state-of-the-art

Hussain, Zahid; Thu, Hnin Ei; Ng, Shiow Fern; Khan, Shahzeb; Katas, Haliza

doi:10.1016/j.colsurfb.2016.11.036

Cited by 168 publications

(91 citation statements)

References 123 publications

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“…Curcumin is limited by its hydrophobic nature, poor water solubility, low bioavailability, and chemical instability. New advances in pharmaceutical strategies, such as nanoencapsulation, may overcome these limitations [1, 18, 21, 23]. Additionally, the isolation of curcumin from the other constituents in turmeric may reduce its therapeutic potential.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the isolation of curcumin from the other constituents in turmeric may reduce its therapeutic potential. Curcumin’s demonstrated therapeutic benefit and increased bioavailability when used as an adjunct drug in therapy supports this argument [1, 4, 18, 21, 23, 33]. A future trial exploring turmeric or a combined nutraceutical therapy for radiation dermatitis may yield positive results.…”

Section: Discussionmentioning

confidence: 99%

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Oral curcumin for radiation dermatitis: a URCC NCORP study of 686 breast cancer patients

Wolf

Heckler

Guido

et al. 2017

Support Care Cancer

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Oral curcumin for radiation dermatitis: a URCC NCORP study of 686 breast cancer patients

Wolf

Heckler

Guido

et al. 2017

Support Care Cancer

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“…Nanomedicine is bridging the gap between pharmaceutical limitations and the therapeutic potentials of natural phytochemicals by improving the compound's targeting, pharmacokinetics, efficacy, and cellular uptake [73][74][75][76][77][78][79][80]. Many studies have focused on CUR nanotechnology mediated drug delivery formulations in optimization the therapeutics uses of CUR for various diseases, such as cancer therapy [81][82][83][84][85][86][87][88][89][90], neurodegenerative disorders [91,92], wound healing [93], diabetes [94,95], and inflammatory diseases [96]. A wide variety of nanomedicine-based drug delivery systems are used to deliver CUR such as liposomes, polymeric nanoparticles, dendrimers, solid lipid nanoparticles, dendrosomes, nanogels, micelles, niosomes, cyclodextrin inclusion complexes, silver and gold nanoparticles, carbon nanotubes, nanoemulsions, nanosuspensions, exosomes, nanocrystals, and mesoporous silica nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases

Salehi

Prado-Audelo

Cortés

et al. 2020

JCM

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Cardiovascular diseases (CVD) compromises a group of heart and blood vessels disorders with high impact on human health and wellbeing. Curcumin (CUR) have demonstrated beneficial effects on these group of diseases that represent a global burden with a prevalence that continues increasing progressively. Pre-and clinical studies have demonstrated the CUR effects in CVD through its anti-hypercholesterolemic and anti-atherosclerotic effects and its protective properties against cardiac ischemia and reperfusion. However, the CUR therapeutic limitation is its bioavailability. New CUR nanomedicine formulations are developed to solve this problem. The present article aims to discuss different studies and approaches looking into the promising role of nanotechnology-based drug delivery systems to deliver CUR and its derivatives in CVD treatment, with an emphasis on their formulation properties, experimental evidence, bioactivity, as well as challenges and opportunities in developing these systems.

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“…At present, intensive research efforts are directed toward leveraging the anticancer effect of curcumin and improving its bioavailability [15] . Interest in this polyphenol is high, and the number of research efforts studying its anticancer activity is steadily increasing [16] .…”

Section: Cell Staining and Analysis For γH2ax And The Cell Cyclementioning

confidence: 99%

Epicatechin acts synergistically with curcumin-induced cytogenotoxic effect in acute promyelocytic leukemia HL-60 cell line

Papież¹,

Krzyściak²

2017

JUMD

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How to cite this article: Papież MA, Krzyściak W. Epicatechin acts synergistically with curcumin-induced cytogenotoxic effect in acute promyelocytic leukemia HL-60 cell line. J Unexplored Med Data 2017;2:52-9. Aim:The low bioavailability of curcumin, a polyphenol, limits its use as an antitumor agent. Identifying mechanisms to improve the bioavailability and effectiveness of curcumin can modify utilization of other plant-derived phenolic compounds. This study was conducted with an aim to determine the influence of some flavonoids on the effects of curcumin in an HL-60 cell line. Methods: Cells were incubated in the presence of different concentrations of curcumin and several flavonoids for 20 h. Cytotoxicity was evaluated using propidium iodide staining. The evaluation of γH2AX expression using a specific antibody, together with study of the cell cycle, was analyzed using flow cytometry. Results: A synergistic effect was obtained only using a combination of curcumin and lower concentrations of epicatechin. The low concentration of quercetin exerted an additive effect only in combination with curcumin. Moreover, incubation with curcumin and epicatechin resulted in a significant increase in the γH2AX level. Conclusion: Combination treatment with epicatechin and curcumin can potentially be considered for improving the effectiveness and bioavailability of curcumin in cell lines of myeloid leukemia. Key words:Polyphenols, cytotoxic effect, γ-H2AX, flow cytometry, HL-60 cell line ABSTRACTArticle history:

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Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin: A review of new trends and state-of-the-art

Cited by 168 publications

References 123 publications

Oral curcumin for radiation dermatitis: a URCC NCORP study of 686 breast cancer patients

Oral curcumin for radiation dermatitis: a URCC NCORP study of 686 breast cancer patients

Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases

Epicatechin acts synergistically with curcumin-induced cytogenotoxic effect in acute promyelocytic leukemia HL-60 cell line

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