Nanoemulsões formuladas para uso tópico: estudo de síntese e toxicidade

Porto, Alice Sperandio; Almeida, Igor Vivian de; Vicentini, Verônica Elisa Pimenta

doi:10.32712/2446-4775.2020.1060

Cited by 6 publications

(4 citation statements)

References 24 publications

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“…The high-resolution transmission electronic microscope produced images obtained from the P3 sample, i.e., which contains 5% of the SME. Thus, through the average size of the particles and the micrograph with a magnification of 5 μm in Figure 5, one can observe several particles agglomerated in nanometric sizes, with an average of 11.28 nm ± 1.09 nm; also, these particles have a spherical shape [35].…”

Section: Transmission Electron Microscopymentioning

confidence: 91%

The Microemulsion with Solubilization of the Ethanolic Extract of the Leaves of Melão-de-São-Caetano (Momordica charantia) and Antibacterial Action

Brito

Camboim

Rossi³

et al. 2023

JFB

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Extracts obtained from plants have significantly contributed to the creation of new drugs due to their medicinal properties, which are provided by the presence of bioactive components. This has led to a growing interest from the pharmaceutical industry in using this type of extract for the creation of increasingly advanced medications. The main components sought are antibacterial agents from sustainable and renewable sources, whether of animal or vegetable origin or derived from other natural components. Tissues become a source of microbial proliferation, especially when in contact with the human body, which can cause serious diseases. In line with this, the goal of this research was to create an antibacterial Melon-de-São-Caetano (Momordica charantia) leaf microemulsion for application on material surfaces. This microemulsified system is an effective alternative for solubilizing functional agents, and being thermodynamically stable, it is efficient for long-term use. For this study, an extract of Momordica charantia leaves (EMC) was obtained, and microemulsions with different EMC concentrations (P1, P2, and P3) were produced. The extract and microemulsions were investigated using Fourier Transform Infrared (FTIR) spectroscopy, particle size, zeta potential, thermal stress, pH, electrical conductivity, Transmission Electron Microscopy (TEM), and antibacterial analysis (Staphylococcus aureus). In summary, the proposed objective was met, and EMC, SME, and the P2 and P3 microemulsions showed positive results against S. aureus, with the P3 microemulsified system being the most effective with a 12.5 mm inhibition halo. Therefore, the product developed in this research has the potential for application on surfaces, providing antibacterial action.

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Section: Transmission Electron Microscopymentioning

confidence: 91%

The Microemulsion with Solubilization of the Ethanolic Extract of the Leaves of Melão-de-São-Caetano (Momordica charantia) and Antibacterial Action

Brito

Camboim

Rossi³

et al. 2023

JFB

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“…Nanoemulsions are dispersed systems between two immiscible liquids, whose droplets have an average size of less than 200 nm, where there is the preparation of an aqueous and oily phase, using surfactants to obtain stable and homogeneous samples (Chircov;Grumezescu, 2019). Thus, nanoemulsions have unique advantages such as conveying both hydrophilic and lipophilic active ingredients in the same formulation, as well as controlling sensory aspects adapted to the needs of the route of administration for which they are intended (Porto;Almeida;Vicentini, 2020). Nanoemulsions however, are very fragile by nature and minimal signs of destabilization appear easily, which may be related to the nature of the oil phase and another from the addition of polymers.…”

Section: Nanoemulsionsmentioning

confidence: 99%

Different açaí by-products in nanostructured formulations: a brief literature review

Nunes,

Machado,

Sabbagh

et al. 2023

DS-CNT

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Açaí (Euterpe oleracea) is a fruit native to the Amazon rainforest which has several well-known properties. Its by-products have physicochemical limitations and the bioactive substances, specifically the polyphenols, are susceptible to degradation by oxidation during exposure to oxygen, humidity, light, high temperatures and pH alteration. In this context, nanotechnology is related to structures, properties and processes involving materials with dimensions on the nanometer scale, and can be used to overcome these limitations due to the fact that these particles are extensively researched because they offer many advantages over traditional formulations. The aim of this study was to prepare a literature review considering the different by-products of açaí, their biological activities and nanostructured materials to which açaí was complexed. The search was carried out using the Scientific Electronic Library Online (SciELO), PubMed and Web of Science databases, and articles were selected that were written in English, published between 2012 -2023 and used the descriptors "nano*" AND "açaí" and "nano*" AND "Euterpe Oleracea". The studies found showed that the most commonly used nanoformulation was the polymeric nanoparticle and three appeared with the same frequency, namely the metallic nanoparticle, nanoemulsion and nanofiber, while the most exploited by-products are oil, fruit and seeds. Majority of studies also found that açaí by-products nanoformulations are used in the food industry, in the creation of biodegradable materials, in the delivery of pharmaceuticals, and in the area of cosmetology. However, only a small number of studies showed evaluations of biological properties of these products.

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“…Emulsões são sistemas líquidos polifásicos, semitransparentes a turvos, termodinamicamente instáveis, compostos pelas fases dispersa e dispersante, cujo comportamento depende do tamanho das gotículas da fase dispersa, na qual a fase interna é estabilizada pela fase contínua (externa), pela ação de um componente emulsionante (tensoativo ou surfactante) (Figura 2). A estabilidade é determinada pelo tempo necessário para que seja possível visualizar a separação das fases, que ocorre lentamente nas emulsões mais estáveis, sendo este um fator determinante para a escolha de suas aplicações (BASTO et al, 2016;DOKANIA;JOSHI, 2015;FRANZOL;REZENDE, 2015;DEORE, 2017;PORTO et al, 2020). Com relação ao uso de emulsões em aplicações terapêuticas, existe a limitação das elevadas concentrações de tensoativos que podem causar dano celular, hemólise e inflamação tecidual (BOTELHO et al, 2018).…”

Section: Classificação Dos Sistemas Carreadores Coloidaisunclassified