Nanoemulsions stabilized by non-ionic surfactants: stability and degradation mechanisms

Koroleva, M. Yu.; Nagovitsina, T.Y.; Yurtov, E. V.

doi:10.1039/c7cp07626f

Cited by 73 publications

(37 citation statements)

References 38 publications

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“…Ostwald ripening is dependent on the oil phase fraction in the nanoemulsion system. The coarsening mechanism in nanoemulsion stabilized with Brij 30 or mixture of Span 80 and Tween-80 has explained that Ostwald ripening is the main cause of coarsening phenomenon in nanoemulsion with low oil phase fraction which up to 0.05 [102].…”

Section: Morphology and Stability Studymentioning

confidence: 99%

Synthesis and Technology of Nanoemulsion-Based Pesticide Formulation

2020

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Declines in crop yield due to pests and diseases require the development of safe, green and eco-friendly pesticide formulations. A major problem faced by the agricultural industry is the use of conventional agrochemicals that contribute broad-spectrum effects towards the environment and organisms. As a result of this issue, researchers are currently developing various pesticide formulations using different nanotechnology approaches. The progress and opportunities in developing nanoemulsions as carriers for plant protection or nanodelivery systems for agrochemicals in agricultural practice have been the subject of intense research. New unique chemical and biologic properties have resulted in a promising pesticide nanoformulations for crop protection. These innovations—particularly the nanoemulsion-based agrochemicals—are capable of enhancing the solubility of active ingredients, improving agrochemical bioavailability, and improving stability and wettability properties during the application, thus resulting in better efficacy for pest control and treatment. All of these—together with various preparation methods towards a greener and environmentally friendly agrochemicals—are also discussed and summarized in this review.

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Section: Morphology and Stability Studymentioning

confidence: 99%

Synthesis and Technology of Nanoemulsion-Based Pesticide Formulation

2020

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“…The highest PDI of 0.487, although arguably monodisperse for batch F4, is bimodal ( Figure 9 ). The droplet size distribution of F4 could be attributed to the high Span ® 20 content due to a shift in HLB for these surfactant mixtures and the effect to thermodynamic stability [ 51 ]. A general decrease in the ZP was observed as the proportion of ethanol used was increased for batches F1 to F3 suggesting that the composition of F1, F2 and F3 would produce stable nanoemulsions over the long term.…”

Section: Resultsmentioning

confidence: 99%

Design, Optimization, Manufacture and Characterization of Efavirenz-Loaded Flaxseed Oil Nanoemulsions

2020

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The formation, manufacture and characterization of low energy water-in-oil (w/o) nanoemulsions prepared using cold pressed flaxseed oil containing efavirenz was investigated. Pseudo-ternary phase diagrams were constructed to identify the nanoemulsion region(s). Other potential lipid-based drug delivery phases containing flaxseed oil with 1:1 m/m surfactant mixture of Tween® 80, Span® 20 and different amounts of ethanol were tested to characterize the impact of surfactant mixture on emulsion formation. Flaxseed oil was used as the oil phase as efavirenz exhibited high solubility in the vehicle when compared to other vegetable oils tested. Optimization of surfactant mixtures was undertaken using design of experiments, specifically a D-optimal design with the flaxseed oil content set at 10% m/m. Two solutions from the desired optimization function were produced based on desirability and five nanoemulsion formulations were produced and characterized in terms of in vitro release of efavirenz, physical and chemical stability. Metastable nanoemulsions containing 10% m/m flaxseed oil were successfully manufactured and significant isotropic gel (semisolid) and o/w emulsions were observed during phase behavior studies. Droplet sizes ranged between 156 and 225 nm, zeta potential between −24 and −41 mV and all formulations were found to be monodisperse with polydispersity indices ≤ 0.487.

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“…When the particle size distribution is polymodal, i.e with a Polydispersity Index (PI) greater than 0.3, nano-emulsions are susceptible to Ostwald ripening degradation. The mechanism of instability is through the chemical potential difference between smaller droplets and larger droplets caused by mass transport between them, and can cause degradation by coalescence or flocculation [45, 46]. Polydispersity index of morphotype A and B nano-emulsions demonstrated uniform particle size and monomodal distribution, thus is stable against Ostwald ripening [47, 48].…”

Section: Resultsmentioning

confidence: 99%

Development of nano-emulsions based onAyapana triplinervisfor the control ofAedes aegyptilarvae

Rodrigues

Lopes

Rabelo

et al. 2020

Preprint

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AbstractAyapana triplinervis is a plant species used in traditional medicine and in mystical-religious rituals by traditional communities in the Amazon. The aim of this study is to evaluate the larvicidal activity against A. aegypti of nano-emulsions containing essential oils from A. triplinervis morphotypes, and acute oral toxicity in non-target organism. Essential oils were identified and nano-emulsions were prepared using the low energy method. The mortality test of A. aegypti larvae was performed according to the protocol recommended by the World Health Organization, and toxicity in non-target mammals was performed according to the OECD. Phytochemical analyses indicated the major compounds (E)-Caryophyllene (45.93%) and Thymohydroquinone Dimethyl Ether (32.93%) in morphotype A, and in morphotype B, Thymohydroquinone Dimethyl Ether (84.53%) was found. Morphotype A essential oil nano-emulsion showed a particle size of 101.400 ± 0.971 nm (PdI = 0.124 ± 0.009 and ZP = −19,300 ± 0.787 mV). Morphotype B essential oil nano-emulsion had a particle size of 104.567 ± 0.416 nm (PdI = 0.168 ± 0.016 and ZP = −27,700 ± 1,307 mV). Histomorphological analyses showed the presence of inflammatory cells in the liver of animals treated with morphotype A essential oil nano-emulsion (MAEON) and morphotype B essential oil nano-emulsion (MBEON). Congestion and the presence of transudate with leukocyte infiltration in the lung of animals treated with MAEON were observed. The nano-emulsions containing essential oils of A. triplinervis morphotypes showed an effective nanobiotechnological product in the chemical control of A. aegypti larvae and safe for non-target mammals.

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Nanoemulsions stabilized by non-ionic surfactants: stability and degradation mechanisms

Cited by 73 publications

References 38 publications

Synthesis and Technology of Nanoemulsion-Based Pesticide Formulation

Synthesis and Technology of Nanoemulsion-Based Pesticide Formulation

Design, Optimization, Manufacture and Characterization of Efavirenz-Loaded Flaxseed Oil Nanoemulsions

Development of nano-emulsions based onAyapana triplinervisfor the control ofAedes aegyptilarvae

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