Nanoemulsions for the Encapsulation of Hydrophobic Actives

Guzmán, Eduardo; Fernández‐Peña, Laura; Rossi, Lorenzo; Bouvier, Mathieu; Ortega, Francisco; Rubio, Ramón G.

doi:10.3390/cosmetics8020045

Cited by 14 publications

(14 citation statements)

References 34 publications

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“…On the other side, the encapsulation process is selected in such a way that can be reproducible, fast, effective, and scalable to an industrial process. Furthermore, the nature of the encapsulated compounds as well as their final application plays a very important role on the design of the encapsulation process [199][200][201][202][203].…”

Section: Encapsulation Of Eos and Eocs In Cosmeticmentioning

confidence: 99%

Essential Oils and Their Individual Components in Cosmetic Products

Guzmán

Lucı́a

2021

Cosmetics

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The current consumer demands together with the international regulations have pushed the cosmetic industry to seek new active ingredients from natural renewable sources for manufacturing more eco-sustainability and safe products, with botanical extract being an almost unlimited source of these new actives. Essential oils (EOs) emerge as very common natural ingredients in cosmetics and toiletries as a result of both their odorous character for the design and manufacturing of fragrances and perfumes, and the many beneficial properties of their individual components (EOCs), e.g., anti-inflammatory, antimicrobial and antioxidant properties, and, nowadays, the cosmetic industry includes EOs or different mixtures of their individual components (EOCs), either as active ingredients or as preservatives, in various product ranges (e.g., moisturizers, lotions and cleanser in skin care cosmetics; conditioners, masks or antidandruff products in hair care products; lipsticks, or fragrances in perfumery). However, the unique chemical profile of each individual essential oil is associated with different benefits, and hence it is difficult to generalize their potential applications in cosmetics and toiletries, which often require the effort of formulators in seeking suitable mixtures of EOs or EOCs for obtaining specific benefits in the final products. This work presents an updated review of the available literature related to the most recent advances in the application of EOs and EOCs in the manufacturing of cosmetic products. Furthermore, some specific aspects related to the safety of EOs and EOCs in cosmetics will be discussed. It is expected that the information contained in this comprehensive review can be exploited by formulators in the design and optimization of cosmetic formulations containing botanical extracts.

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Section: Encapsulation Of Eos and Eocs In Cosmeticmentioning

confidence: 99%

Essential Oils and Their Individual Components in Cosmetic Products

Guzmán

Lucı́a

2021

Cosmetics

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“…The latter can contribute to improving the functionality or the sensorial feeling associated with the use of the formulation, provide fragrance, or simply enhance the quality of the final product (e.g., increase their stability or modify their viscosity and texture) [6,7]. The most common stabilizers of cosmetic emulsions are conventional surfactants, e.g., tween 80, span 80, sodium laureth sulfate (SLES), sodium lauryl sulfate (SLS), sodium dodecyl sulfate (SDS), cocamidopropyl betaine (CAPB) or polyethyleneglycol ethers [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Pickering Emulsions: A Novel Tool for Cosmetic Formulators

2022

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The manufacturing of stable emulsion is a very important challenge for the cosmetic industry, which has motivated intense research activity for replacing conventional molecular stabilizers with colloidal particles. These allow minimizing the hazards and risks associated with the use of conventional molecular stabilizers, providing enhanced stability to the obtained dispersions. Therefore, particle-stabilized emulsions (Pickering emulsions) present many advantages with respect to conventional ones, and hence, their commercialization may open new avenues for cosmetic formulators. This makes further efforts to optimize the fabrication procedures of Pickering emulsions, as well as the development of their applicability in the fabrication of different cosmetic formulations, necessary. This review tries to provide an updated perspective that can help the cosmetic industry in the exploitation of Pickering emulsions as a tool for designing new cosmetic products, especially creams for topical applications.

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“…Among the advantages of using NE we can highlight the improvement of the bioavailability of hydrophobic drugs [11]. Considerable research is nowadays ongoing to encapsulate hydrophobic drugs for improved bioavailability, safety, and efficacy [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

A quality by design approach for the synthesis of palmitoyl carnitine loaded nanoemulsions as drug delivery systems

Urea

Hernando

Barriga

et al. 2022

Preprint

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Nanoemulsions (NE) are lipid nanocarriers that can efficiently load hydrophobic active compounds, like palmitoyl-L-carnitine (pC), used here as model molecule. The use of design of experiments (DoE) approach is a useful tool to develop NE with optimized properties, requiring less experiments compared to trial-and-error approach. The optimized formulation was studied for its stability, scalability, pC entrapment, loading capacity, and biodistribution in mice. NE were prepared by the solvent injection technique. DoE was implemented for designing pC-loaded NE, using a two-level fractional factorial design as model. NE were fully characterized by a combination of techniques, and biodistribution was studied ex-vivo after injection of fluorescent NE in healthy mice. We selected the optimal formulation of NE, named pC-NEU, after DoE analysis of four variables. pC-NEU incorporated pC in a very efficient manner, with high entrapment efficiency and loading capacity. pC-NEU did not change its initial colloidal properties stored at 4ºC in water during 120 days, nor in buffers with different pH values (5.3 and 7.4) during 30 days. The scalability process did not affect NE stability properties. Biodistribution study showed that pC-NEU formulation was predominantly concentrated in the liver, with minimal accumulation in spleen, stomach and kidneys.

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Nanoemulsions for the Encapsulation of Hydrophobic Actives

Cited by 14 publications

References 34 publications

Essential Oils and Their Individual Components in Cosmetic Products

Essential Oils and Their Individual Components in Cosmetic Products

Pickering Emulsions: A Novel Tool for Cosmetic Formulators

A quality by design approach for the synthesis of palmitoyl carnitine loaded nanoemulsions as drug delivery systems

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