Nanoemulsions for Intravenous Drug Delivery

Fast, Jonathan P.; Mecozzi, Sandro

doi:10.1007/978-0-387-77668-2_15

Cited by 13 publications

(12 citation statements)

References 85 publications

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“…All signals were normalized to maximum amplitude, and the droplet diameter was determined by matching the measured photoacoustic spectral maxima and minima to the model [Eq. (2)]. The diameter found from the spectral fit agreed well with the time domain photoacoustic and ultrasound methods used to calculate the diameter (see Table 1).…”

Section: Photoacoustic Spectral Measurementssupporting

confidence: 67%

“…The acoustic properties of gelatin and water are very similar, 38 and the spectral features only depend on the sound speed and density of the droplet and coupling fluid in Eq. (2). Therefore it is unlikely the change in medium between similar liquids would significantly affect the spectral shape.…”

Section: Acoustic and Photoacoustic Measurementsmentioning

confidence: 99%

“…(2)] calculates the photoacoustic pressure wave emitted from a spherical homogeneous liquid undergoing thermoelastic expansion due to absorption of optical energy. To determine if the measured photoacoustic spectra from NPloaded PFH droplets were in agreement with the model, the photoacoustic signals for three droplets of different sizes were measured: a 5.7-μm droplet measured at 375 MHz, a 2.45-μm droplet measured at 750 MHz, and a 6.95-μm droplet measured at 750 MHz (Fig.…”

Section: Photoacoustic Spectral Measurementsmentioning

confidence: 99%

“…PFCs are biologically and chemically inert, which makes them appealing for use in medicine, 1 and they can be emulsified into nano-or micronsized droplets 2 to overcome their insolubility in water for in vivo infusion. In 2000, it was reported that a liquid-to-gas phase change could be induced in PFC emulsions via ultrasound irradiation using a method called acoustic droplet vaporization (ADV).…”

Section: Introductionmentioning

confidence: 99%

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Acoustic and photoacoustic characterization of micron-sized perfluorocarbon emulsions

et al. 2012

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Abstract. Perfluorocarbon droplets containing nanoparticles (NPs) have recently been investigated as theranostic and dual-mode contrast agents. These droplets can be vaporized via laser irradiation or used as photoacoustic contrast agents below the vaporization threshold. This study investigates the photoacoustic mechanism of NPloaded droplets using photoacoustic frequencies between 100 and 1000 MHz, where distinct spectral features are observed that are related to the droplet composition. The measured photoacoustic spectrum from NP-loaded perfluorocarbon droplets was compared to a theoretical model that assumes a homogenous liquid. Good agreement in the location of the spectral features was observed, which suggests the NPs act primarily as optical absorbers to induce thermal expansion of the droplet as a single homogenous object. The NP size and composition do not affect the photoacoustic spectrum; therefore, the photoacoustic signal can be maximized by optimizing the NP optical absorbing properties. To confirm the theoretical parameters in the model, photoacoustic, ultrasonic, and optical methods were used to estimate the droplet diameter. Photoacoustic and ultrasonic methods agreed to within 1.4%, while the optical measurement was 8.5% higher; this difference decreased with increasing droplet size. The small discrepancy may be attributed to the difficulty in observing the small droplets through the partially translucent phantom.

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Section: Photoacoustic Spectral Measurementssupporting

confidence: 67%

Section: Acoustic and Photoacoustic Measurementsmentioning

confidence: 99%

Section: Photoacoustic Spectral Measurementsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Acoustic and photoacoustic characterization of micron-sized perfluorocarbon emulsions

et al. 2012

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“…A representative list of marketed nanoemulsions for intravenous delivery of poorly water-soluble drugs (3).…”

Section: Table Imentioning

confidence: 99%

Diazepam-loaded parenteral nanoemulsions: Physicochemical characterization and in vitro release study

Djordjevic¹,

Isailović²,

Cekić³

et al. 2016

Arh farmaciju

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Cilj ovog istraživanja bio je da se razviju parenteralne nanoemulzije sa rastućom koncentracijom uljane faze (20, 30 i 40% smeše triglicerida srednje dužine lanca i sojinog ulja u odnosu 4:1), stabilizovane kombinacijom lecitina i polisorbata 80, i da se proceni njihova pogodnost kao nosača za slabo rastvorljive psihofarmakološke lekovite supstance. U tu svrhu, homogenizacijom pod visokim pritiskom izrađene su nanoemulzije sa diazepamom kao model lekovitom supstancom i okarakterisane u pogledu veličine kapi, indeksa polidisperznosti, površinskog naelektrisanja, viskoziteta, pH vrednosti i električne provodljivosti. Takođe, primenom reverzne tehnike sa dijaliznim vrećicama procenjena je brzina oslobađanja diazepama iz razvijenih nanoemulzija, uz karakterizaciju dobijenih profila oslobađanja primenom različitih matematičkih modela. Nakon izrade, sve formulacije imale su malu prosečnu veličinu kapi (206 ± 7 nm), sa uskom raspodelom veličina (0,116 ± 0,012) i zeta potencijalom oko -50 mV, što je u skladu sa farmakopejskim zahtevima (USP 39-NF 34) pri čemu se vrednosti navedenih parametara nisu značajno promenile nakon godinu dana čuvanja na 25 ± 2°C. In vitro ispitivanje brzine oslobađanja pokazalo je da se 40-50% diazepama oslobodi iz ispitivanih nanoemulzija tokom 1 h, pri čemu se kinetika oslobađanja može opisati Korsmeyer-Peppas modelom. Dobijeni rezultati ukazuju da formulisane parenteralne nanoemulzije predstavljaju obećavajuće nosače za brzu isporuku slabo rastvorljivih psihofarmakoloških lekovitih supstanci.Ključne reči: nanoemulzija; parenteralna primena; diazepam; stabilnost; reverzna tehnika sa dijaliznim vrećicama.

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Facile Formation of Medium‐Chain‐Length Poly‐3‐Hydroxyalkanoates (mcl‐PHA)‐Incorporated Nanoparticle Using Combination of Non‐Ionic Surfactants

Ishak

Annuar

2017

J Surfact & Detergents

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The assembly of nanoparticles incorporating bacterial medium‐chain‐length poly‐3‐hydroxyalkanoates (mcl‐PHA) via phase inversion emulsification (PIE) was investigated. Sequential addition of water into an agitated mixture of carrier oil (jojoba oil), nonionic surfactants (Cremophor EL and Span 80) and melted mcl‐PHA triggered phase inversion of water‐in‐oil (W/O) to oil‐in‐water (O/W) emulsion. The emulsion inversion point (EIP) at 30% w/w of water content was determined by abrupt changes in viscosity and conductivity of the suspension. Concurrently, infrared transmittance of the O–H group of water, the C–O–C group of surfactants and the C–H group of alkane chain were practically identical while Small Angle X‐ray Scattering indicated the presence of a bi‐continuous/lamellar structure. The morphology of the emulsion changed, with increasing water content, from W/O to bi‐continuous/lamellar structure and finally to O/W. mcl‐PHA appears to form a bridging polymeric network, covering the nanoparticle with a protective layer for enhanced protection of the encapsulated compound. A hypothetical mechanism for the mcl‐PHA‐based nanoparticle assembly is also proposed.

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Nanoemulsions for Intravenous Drug Delivery

Cited by 13 publications

References 85 publications

Acoustic and photoacoustic characterization of micron-sized perfluorocarbon emulsions

Acoustic and photoacoustic characterization of micron-sized perfluorocarbon emulsions

Diazepam-loaded parenteral nanoemulsions: Physicochemical characterization and in vitro release study

Facile Formation of Medium‐Chain‐Length Poly‐3‐Hydroxyalkanoates (mcl‐PHA)‐Incorporated Nanoparticle Using Combination of Non‐Ionic Surfactants

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