Nanoemulsions and topical creams for the safe and effective delivery of lipophilic antioxidant coenzyme Q10

Kaci, Messaouda; Belhaffef, A.; Meziane, Smail; Dostert, Gabriel; Menu, Patrick; Velot, Émilie; Desobry, Stéphane; Arab‐Tehrany, Elmira

doi:10.1016/j.colsurfb.2018.04.010

Cited by 58 publications

(25 citation statements)

References 35 publications

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“…High-energy approaches include high-pressure homogenization, ultrasonification and high-speed homogenization (Komaiko and McClements 2016). These methods for formation of nanoemulsions use the high intense force to rupture the large droplets into small ones by using the mechanical devices such as high-pressure homogenizers, microfluidizers, sonicators and high-speed devices (rotor/stator devices) (Kaci et al 2018;Dey et al 2018;Katsouli et al 2018;Luo et al 2017). This approach depends on many factors for obtaining the smallest size of the droplets such as operating conditions, homogenizer type and composition of a sample and physico-chemical properties of the different phases.…”

Section: Nanoemulsions-based Delivery System For Bioactive Compounds mentioning

confidence: 99%

Valorization of fruits and vegetables waste through green extraction of bioactive compounds and their nanoemulsions-based delivery system

Saini

Panesar

Bera

2019

Bioresour. Bioprocess.

144

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Fruits and vegetables, a significant segment of food sector, generate large volume of wastes annually. They constitute an excellent source of several valuable components (carotenoids, polyphenols, etc.), also known as bioactive compounds. These bioactive compounds have a positive impact on health and are known to modulate the metabolic processes as well as influence the cellular activities in the human health due to their antioxidant, anti-cancer, antiinflammation, anti-allergenic and anti-atherogenic properties; depending upon the pathway and their bioavailability in the body. Despite this, some of these compounds are hydrophobic in nature and therefore are less bioavailable in the body. However, with the technological advancements like nanoemulsions, their solubility, stability and functional properties can be enhanced. This review provides the comprehensive information about the green extraction techniques and innovative delivery system such as nanoemulsions for bioactive compounds generated from fruits and vegetables waste. which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. ReferencesAbdelkarim G (2014) What is a bioactive compounds? A combined definition for a preliminary consensus. Int J Nutr Food Sci 3:174-179 Agócs A, Nagy V, Szabó Z, Márk L, Ohmacht R, Deli J (2007) Comparative study on the carotenoid composition of the peel and the pulp of different citrus species. Innov Food Sci Emerg Technol 8(3):390-394 Ajila CM, Aalami M, Leelavathi K, Rao UP (2010) Mango peel powder: a potential source of antioxidant and dietary fiber in macaroni preparations. Innov Food Sci Emerg Technol 11:219-224 Alupului A, Čalinescu I, Lavric V (2012) Microwave extraction of active principles from medicinal plants. UPB Sci Bull Ser B Chem Mater Sci 74:129-142 Ameer K, Shahbaz HM, Kwon JH (2017) Green extraction methods for polyphenols from plant matrices and their byproducts: a review. Compr Rev Food Sci Food Saf 16:295-315 An Y, Yan X, Li B, Li Y (2014) Microencapsulation of capsanthin by self-emulsifying nanoemulsions and stability evaluation. Application of pulsed electric field in the production of juice and extraction of bioactive compounds from blueberry fruits and their by-products. J Food Sci Technol 52:5898-5905 Boussetta N, Vorobiev E, Le LH, Cordin-Falcimaigne A, Lanoisselle JL (2012) Application of electrical treatments in alcoholic solvent for polyphenols extraction from grape seeds. LWT-Food Sci Technol 46:127-134 Bryant G, Wolfe J (1987) Electromechanical stress produced in the plasma membranes of suspended cells by applied electrical fields. J Membr Biol 96:129-139 Chandrasekar V, Martín-González MFS, Hirst P, Ballard TS (2015) Optimizing microwave-assisted extraction of phenolic antioxidants from red delicious and jonathan apple pomace. J Food Process Eng 38:571-582 Chanfrau CJER, Armas TML (2014) Ultrasound assisted extract...

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Section: Nanoemulsions-based Delivery System For Bioactive Compounds mentioning

confidence: 99%

Valorization of fruits and vegetables waste through green extraction of bioactive compounds and their nanoemulsions-based delivery system

Saini

Panesar

Bera

2019

Bioresour. Bioprocess.

144

View full text Add to dashboard Cite

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“…Subsequent studies reported during the 2000s demonstrated multiple benefits of coenzyme Q 10 in both animal models and human skin, which included skin anti-aging properties and, through supplementation, a potential treatment for psoriasis [ 139 , 140 , 141 , 142 ]. Additionally, more recent studies from 2015 through 2018 validated the: (a) antioxidant effects of coenzyme Q 10 to support and maintain cellular energy levels in human keratinocytes [ 143 , 144 ], (b) accelerated regeneration of ATP levels after irradiation in human fibroblasts [ 144 , 145 ], and (c) the safety and effective delivery of coenzyme Q 10 into the epidermis to improved human skin health [ 143 , 144 , 145 ].…”

Section: Coenzyme Q 10mentioning

confidence: 99%

Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome

Vollmer¹,

West²,

Lephart

2018

IJMS

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The history of cosmetics goes back to early Egyptian times for hygiene and health benefits while the history of topical applications that provide a medicinal treatment to combat dermal aging is relatively new. For example, the term cosmeceutical was first coined by Albert Kligman in 1984 to describe topical products that afford both cosmetic and therapeutic benefits. However, beauty comes from the inside. Therefore, for some time scientists have considered how nutrition reflects healthy skin and the aging process. The more recent link between nutrition and skin aging began in earnest around the year 2000 with the demonstrated increase in peer-reviewed scientific journal reports on this topic that included biochemical and molecular mechanisms of action. Thus, the application of: (a) topical administration from outside into the skin and (b) inside by oral consumption of nutritionals to the outer skin layers is now common place and many journal reports exhibit significant improvement for both on a variety of dermal parameters. Therefore, this review covers, where applicable, the history, chemical structure, and sources such as biological and biomedical properties in the skin along with animal and clinical data on the oral applications of: (a) collagen, (b) ceramide, (c) β-carotene, (d) astaxanthin, (e) coenzyme Q10, (f) colostrum, (g) zinc, and (h) selenium in their mode of action or function in improving dermal health by various quantified endpoints. Lastly, the importance of the human skin microbiome is briefly discussed in reference to the genomics, measurement, and factors influencing its expression and how it may alter the immune system, various dermal disorders, and potentially be involved in chemoprevention.

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“…For preparation of bio-based NEs many compounds of natural origin, including encapsulated active ingredients (e.g., essential oils; EOs), but also plant oils for NE oil phase (e.g., palm oil, rapeseed oil, sunflower oil etc.) (e.g., Raviadaran et al 2018;Kaci et al 2018;Abdou et al 2018), emulsifiers, biosurfactants or cosurfactants (e.g., Quillaja saponin, phospholipids, lecithin, gum arabic, pectin, whey protein, lactoferrin, lactoferrin/alginate) McClements and Gumus 2016;Ozturk et al 2014Ozturk et al , 2015Liu et al 2017;Verma et al 2016;Artiga-Artigas et al 2018;Zhao et al 2018a;Pinheiro et al 2016), or targeting ligands on the surface of NE such as folate (Liu et al 2017;Ganta et al 2016;Afzal et al 2016a) increasing drug bioavailability, reducing undesirable side effects, minimizing non-specific uptake and thus allowing specific targeting to certain target cells are used. Targeting technology usually utilizes the nanocarrier functionalization, which can be surface modification (e.g., Attia et al 2017;Liu et al 2017) and/or ligand grafting (e.g., Geng et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Bio-Based Nanoemulsion Formulations Applicable in Agriculture, Medicine, and Food Industry

Jampílek

Kráľová

Campos

et al. 2019

Nanotechnology in the Life Sciences

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Nanotechnology providing "a new dimension" accompanied with new properties conferred to many current materials is widely used for production of a new generation of agrochemicals, in medicine it enables improved drug bioavailability, reducing undesirable side effects, minimizing non-specific uptake and specific targeting to certain target cells, while in food industry it has great importance in food protection and biofortification of food with valuable ingredients. In biobased nanoemulsions belonging to lipid nanocarriers plant oils used for oil phase, emulsifiers, biosurfactants, cosurfactants, targeting ligands on the surface of nanoemulsion (e.g., folate) or encapsulated active ingredients are of natural origin. The biocomponents of such nanoemulsions show low toxicity to living organisms, could protect encapsulated compounds for degradation, ensure their sustainable release and reduce the amount of active ingredient necessary for required effect. This chapter presents a comprehensive current overview of recent findings in the field of nanoemulsions and their utilization in agriculture and food industry, with the main emphasis on formulations encapsulating essential oils or plant extracts suitable as effective pesticide preparations as well as medicinal applications of bio-based nanoemulsions, where attention is paid to transdermal nanoemulsion formulations, the use of nanoemulsions in cancer therapy and for pulmonary and ocular drug delivery. Nanoemulsions formulated with natural emulsifiers, biosurfactants and biopolymers are presented and bio-based nanoemulsions of essential oils and their constituents as well as nanoemulsions with encapsulated vitamins, fatty acids and some bioactive compounds are discussed. Applications of nanoemulsions in edible coatings are outlined as well.

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Nanoemulsions and topical creams for the safe and effective delivery of lipophilic antioxidant coenzyme Q10

Cited by 58 publications

References 35 publications

Valorization of fruits and vegetables waste through green extraction of bioactive compounds and their nanoemulsions-based delivery system

Valorization of fruits and vegetables waste through green extraction of bioactive compounds and their nanoemulsions-based delivery system

Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome

Bio-Based Nanoemulsion Formulations Applicable in Agriculture, Medicine, and Food Industry

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