Nanoemulsion is an Effective Antimicrobial for Methicillin-Resistant
            <i>Staphylococcus Aureus</i>
            in Infected Wounds

Cao, Zeyuan; Spilker, Theodore; Fan, Yongyi; Kalikin, Linda M.; Ciotti, Susan; LiPuma, John J.; Makidon, Paul E.; Wilkinson, John E.; Baker, James R.; Wang, Su He

doi:10.2217/nnm-2017-0025

Cited by 29 publications

(29 citation statements)

References 34 publications

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“…Despite the high prevalence of IA in immunocompromised patients with a high morbidity and even higher mortality, not much is known about A. fumigatus. With this in mind we tested the efficacy of NB-201 in vitro with results similar to that observed in C. albicans (table 2) or methicillin-resistant S. aureus (14). Due to the large abundance of conidia present in the air A. fumigatus primarily infects the respiratory tract (32).…”

Section: Discussionmentioning

confidence: 93%

“…Previously, NB-201 presented a highly effective antimicrobial potential against various methicillin-resistant S. aureus strains both in vitro and in vivo (14). The surfactant in NB-201, benzalkonium chloride, is a known biocide found in many over-the-counter antibacterial handwipes, antiseptic creams, and other medically relevant consumer products (24).…”

Section: Discussionmentioning

confidence: 99%

“…Membrane disruptive nanoemulsions have been developed to control pathogenic bacteria (14, 15). One example is the nanoemulsion NB-201, which is an emulsification of refined soybean oil, water, glycerol, EDTA, Tween 20, and the surfactant benzalkonium chloride (BZK), which is commonly used as an antimicrobial preservative in drugs, topical antiseptic, clinical disinfectant, and as a sanitation agent in the food industry (14, 16–18). The NB-201 formulation exhibited in vitro growth inhibition activity against Pseudomonas aeruginosa and in vivo activity in a burnt wound animal model.…”

Section: Introductionmentioning

confidence: 99%

“…Treatment of animals infected with Staphylococcus aureus with NB-201 by using a murine skin abrasion wound model demonstrated the therapeutic potential of this nanoemulsion formulation (19, 20). NB-201 has also shown activity against Multi-Drug Resistant S. aureus (MRSA) in a study using a porcine burnt wound model (14). The NB-201 formulation is also able to greatly reduce the inflammation of infected wounds and is nontoxic to the skin making it a viable method of treatment for topical bacterial infections (14).…”

Section: Introductionmentioning

confidence: 99%

“…NB-201 has also shown activity against Multi-Drug Resistant S. aureus (MRSA) in a study using a porcine burnt wound model (14). The NB-201 formulation is also able to greatly reduce the inflammation of infected wounds and is nontoxic to the skin making it a viable method of treatment for topical bacterial infections (14).…”

Section: Introductionmentioning

confidence: 99%

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A Nanoemulsion as an Effective Treatment Against Human Pathogenic Fungi

Garcia

Fan

Vellanki

et al. 2019

Preprint

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31The emergence of immunocompromising diseases such as HIV/AIDS or other 32 immunosuppressive medical conditions have opened an opportunity for fungal infections to 33 afflict patients globally. An increase antifungal drug resistant fungi have posed a serious threat 34 to patients. Combining these circumstances with a limited variety of antifungal drugs available to 35 treat patients has left us in a situation where we need to develop new therapeutic approaches 36 that are less prone to development of resistance by pathogenic fungi. In this study we present 37 the utilization of the nanoemulsion NB-201 to control human pathogenic fungi. We found that 38 the NB-201 exhibited in vitro activity against C. albicans, including both planktonic growth and 39 biofilms. Furthermore, treatments with NB-201 significantly reduced the fungal burden at the 40 infection site and presented enhanced healing process after subcutaneous infections by multi-41 drug resistant C. albicans in a murine host system. NB-201 also exhibited in vitro growth 42 inhibition activity against other fungal pathogens, including Cryptococcus spp, Aspergillus 43 fumigatus, and Mucorales. Due to the nature of the activity of this nanoemulsion, there is a 44 minimized chance of drug resistance to develop, thus presents a novel treatment to control 45 fungal wound or skin infections. 46 47 48 49 50 51 52 53

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%