Nanoemulsion Containing Kojic Dipalmitate and Rosehip Oil: A Promising Formulation to Treat Melasma

Zilles, Júlia Capp; Duarte, Larissa Pedron; Ruaro, Thaís Carine; Zimmer, Aline Rigon; Külkamp‐Guerreiro, Irene Clemes; Contri, Renata Vidor

doi:10.3390/pharmaceutics15020468

Cited by 7 publications

(6 citation statements)

References 42 publications

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“…However, this aspect did not influence the accumulation of both products in the epidermis (1.2 μg/cm 2 ). Also, both formulations prove to be safe as no decrease in fibroblast cell viability has been observed ( Zilles et al, 2023 ). The current investigation which designed nanoemulsions with droplet sizes of around 100 nm, may be able to permeate the skin ( Contri et al, 2016a ), particularly in cases of stratum corneum damage.…”

Section: Efficacy Of Rosehip As a Therapeutic Agent Against Multiple ...mentioning

confidence: 99%

Unveiling the mechanisms for the development of rosehip-based dermatological products: an updated review

Oargă (Porumb),

Cornea-Cipcigan,

Cordea

2024

Front. Pharmacol.

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Rosa spp., commonly known as rosehips, are wild plants that have traditionally been employed as herbal remedies for the treatment of a wide range of disorders. Rosehip is a storehouse of vitamins, including A, B complex, C, and E. Among phytonutrients, vitamin C is found in the highest amount. As rosehips contain significant levels of vitamin C, they are perfect candidates for the development of skincare formulations that can be effectively used in the treatment of different skin disorders (i.e., scarring, anti-aging, hyperpigmentation, wrinkles, melasma, and atopic dermatitis). This research focuses on the vitamin C content of several Rosa sp. by their botanical and geographic origins, which according to research studies are in the following order: R. rugosa > R. montana > R. canina > R. dumalis, with lower levels in R. villosa and R. arvensis, respectively. Among rosehip species, R. canina is the most extensively studied species which also displays significant amounts of bioactive compounds, but also antioxidant, and antimicrobial activities (e.g., against Propionibacterium acnes, Staphylococcus aureus, S, epidermis, and S. haemolyticus). The investigation also highlights the use of rosehip extracts and oils to minimise the harmful effects of acne, which primarily affects teenagers in terms of their physical appearance (e.g., scarring, hyperpigmentation, imperfections), as well as their moral character (e.g., low self-confidence, bullying). Additionally, for higher vitamin C content from various rosehip species, the traditional (i.e., infusion, maceration, Soxhlet extraction) and contemporary extraction methods (i.e., supercritical fluid extraction, microwave-assisted, ultrasonic-assisted, and enzyme-assisted extractions) are highlighted, finally choosing the best extraction method for increased bioactive compounds, with emphasis on vitamin C content. Consequently, the current research focuses on assessing the potential of rosehip extracts as medicinal agents against various skin conditions, and the use of rosehip concentrations in skincare formulations (such as toner, serum, lotion, and sunscreen). Up-to-date studies have revealed that rosehip extracts are perfect candidates as topical application products in the form of nanoemulsions. Extensive in vivo studies have revealed that rosehip extracts also exhibit specific activities against multiple skin disorders (i.e., wound healing, collagen synthesis, atopic dermatitis, melasma, and anti-aging effects). Overall, with multiple dermatological actions and efficacies, rosehip extracts and oils are promising agents that require a thorough investigation of their functioning processes to enable their safe use in the skincare industry.

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Section: Efficacy Of Rosehip As a Therapeutic Agent Against Multiple ...mentioning

confidence: 99%

Unveiling the mechanisms for the development of rosehip-based dermatological products: an updated review

Oargă (Porumb),

Cornea-Cipcigan,

Cordea

2024

Front. Pharmacol.

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“…The main advantages of kojic dipalmitate over kojic acid would be its photostability, thermal stability, and stability at a wide range of pH in various topical formulations. However, due to the crystallinity nature, high lipophilicity, and low water solubility of kojic dipalmitate, its incorporations within the topical formulations would be more challenging ( Zilles et al, 2023 ). Based on the previous studies, a combination of topical kojic acid and hydroquinone would be a promising depigmenting agent regimen.…”

Section: Therapeutic Options and Limitationsmentioning

confidence: 99%

Different therapeutic approaches in melasma: advances and limitations

Ghasemiyeh,

Fazlinejad,

Kiafar

et al. 2024

Front. Pharmacol.

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Melasma is a chronic hyperpigmentation skin disorder that is more common in the female gender. Although melasma is a multifactorial skin disorder, however, sun-exposure and genetic predisposition are considered as the main etiologic factors in melasma occurrence. Although numerous topical and systemic therapeutic agents and also non-pharmacologic procedural treatments have been considered in melasma management, however, the commonly available therapeutic options have several limitations including the lack of sufficient clinical effectiveness, risk of relapse, and high rate of unwanted adverse drug reactions. Recruitment of nanotechnology for topical drug delivery in melasma management can lead to enhanced skin penetration, targeted drug delivery to the site of action, longer deposition at the targeted area, and limit systemic absorption and therefore systemic availability and adverse drug reactions. In the current review, first of all, the etiology, pathophysiology, and severity classification of melasma have been considered. Then, various pharmacologic and procedural therapeutic options in melasma treatment have been discussed. Afterward, the usage of various types of nanoparticles for the purpose of topical drug delivery for melasma management was considered. In the end, numerous clinical studies and controlled clinical trials on the assessment of the effectiveness of these novel topical formulations in melasma management are summarized.

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“…Kojic Acid Dipalmitate is one of the active ingredients that has been formulated in a nanoemulsion preparation using the high-energy method, employing the Ultra-Turax [126]. The study suggests that nanoemulsions serve as effective carriers, enhancing both the stability [148] and activity [72] of KDP on the skin.…”

Section: Nanoemulsionmentioning

confidence: 99%

Nanotechnology-Enhanced Cosmetic Application of Kojic Acid Dipalmitate, a Kojic Acid Derivate with Improved Properties

Ayuhastuti,

Syah,

Megantara

et al. 2024

Cosmetics

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Kojic acid (KA) has emerged as a prominent tyrosinase inhibitor with considerable potential in cosmetic applications; however, its susceptibility to instability during storage poses a challenge to its widespread use. This review explores the advancements in addressing this limitation through the development of various KA derivatives, focusing on the modification of the C-7 hydroxyl group. Strategies such as esterification, hydroxy-phenyl ether formation, glycosylation, and incorporation into amino acid or tripeptide derivatives have been employed to enhance stability and efficacy. Among these derivatives, Kojic Acid Dipalmitate (KDP), a palmitic ester derivative of KA, stands out for its notable improvements in stability, permeability, and low toxicity. Recent developments indicate a growing utilization of KDP in cosmetic formulations, with over 132 available products on the market, encompassing various formulations. Formulations based on nanotechnology, which incorporate KDP, have been provided, including nanosomes, nanocreams, multiple emulsions, liposomes, solid lipid nanoparticles (SLNs), ethosomes, and nanoemulsions. Additionally, three patents and seven advanced system deliveries of KDP further underscore its significance. Despite its increasing prevalence, the literature on KDP remains limited. This review aims to bridge this gap by providing insights into the synthesis process, physicochemical properties, pharmaceutical preparation, diverse applications of KDP in cosmetic products, and recent nanotechnology formulations of KDP. This review paper seeks to explore the recent developments in the use of KDP in cosmetics. The goal is to enhance stability, permeability, and reduce the toxicity of KA, with the intention of promoting future research in this promising sector.

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Nanoemulsion Containing Kojic Dipalmitate and Rosehip Oil: A Promising Formulation to Treat Melasma

Cited by 7 publications

References 42 publications

Unveiling the mechanisms for the development of rosehip-based dermatological products: an updated review

Unveiling the mechanisms for the development of rosehip-based dermatological products: an updated review

Different therapeutic approaches in melasma: advances and limitations

Nanotechnology-Enhanced Cosmetic Application of Kojic Acid Dipalmitate, a Kojic Acid Derivate with Improved Properties

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