2023
DOI: 10.1155/2023/6640103
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Nanoemulsion: An Emerging Novel Technology for Improving the Bioavailability of Drugs

Preeti,
Sharda Sambhakar,
Rohit Malik
et al.

Abstract: The pharmaceutical sector has made considerable strides recently, emphasizing improving drug delivery methods to increase the bioavailability of various drugs. When used as a medication delivery method, nanoemulsions have multiple benefits. Their small droplet size, which is generally between 20 and 200 nanometers, creates a significant interfacial area for drug dissolution, improving the solubility and bioavailability of drugs that are weakly water-soluble. Additionally, nanoemulsions are a flexible platform … Show more

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Cited by 24 publications
(7 citation statements)
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“…The extract was weighed according to the concentration, then added tween 80, pine oil, and glycerin each time the addition of the material was stirred with a magnetic bar for 10 minutes at a speed of 250 rpm, and distilled water was added little by a little while stirring at a speed of 500 rpm for 10 minutes until the volume of the preparation was 100 mL. Stirring reduces the interfacial tension to reduce the particle size, but if the stirring is too fast, the globules in the nanoemulsion will collide more easily and can make the nanoemulsion cloudy 34 . The result of the physical evaluation can be seen in Table VIII.…”
Section: Resultsmentioning
confidence: 99%
“…The extract was weighed according to the concentration, then added tween 80, pine oil, and glycerin each time the addition of the material was stirred with a magnetic bar for 10 minutes at a speed of 250 rpm, and distilled water was added little by a little while stirring at a speed of 500 rpm for 10 minutes until the volume of the preparation was 100 mL. Stirring reduces the interfacial tension to reduce the particle size, but if the stirring is too fast, the globules in the nanoemulsion will collide more easily and can make the nanoemulsion cloudy 34 . The result of the physical evaluation can be seen in Table VIII.…”
Section: Resultsmentioning
confidence: 99%
“…The melting points of oils increase with the chain length of fatty acid and decrease with the degree of unsaturation, which also increases susceptibility to oxidation. Isolation of natural oils into glycerides fraction is further used to prepare excipients that maximize desired physical and drug fascination promising properties which reduces susceptibility to oxidation [ 130 , 131 ]. Semisynthetic Lipids .…”
Section: Oral Bioavailability Enhancement Approachesmentioning
confidence: 99%
“…The emulsifier: coemulsifier ratio has been establishing an important aspect for improving the phase behaviors, i.e., size and emulsification position part. The typical orientation is to elect formulation component with the low emulsifier's concentration for oral route of administration [ 130 , 131 ].…”
Section: Oral Bioavailability Enhancement Approachesmentioning
confidence: 99%
“…hydrophobic drugs in the dispersed oil phase and hydrophilic proteins in the continuous aqueous phase), they are considered promising drug delivery vehicles to deliver hydrophobic drugs, and have been used as adjuvants for vaccines, demonstrating their clinical significance. [240][241][242]…”
Section: Nanoemulsionsmentioning
confidence: 99%