Nanodrug with dual-sensitivity to tumor microenvironment for immuno-sonodynamic anti-cancer therapy

Huang, Jinsheng; Xiao, Zecong; An, Yongcheng; Han, Shisong; Wu, Wei; Wang, Yong; Guo, Yu; Shuai, Xintao

doi:10.1016/j.biomaterials.2020.120636

Cited by 149 publications

(101 citation statements)

References 46 publications

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“…In addition, new ways to improve the effectiveness of PDT are constantly being discovered. Regarding the combination of PDT and other forms of anti-cancer therapy, a large amount of preclinical evidence has been collected, and it seems to be increasing rapidly [141,142]. Especially promising is the combination of PDT with chemotherapy, immunotherapy, and targeted therapy.…”

Section: Discussionmentioning

confidence: 99%

Metal Nanoparticles for Photodynamic Therapy: A Potential Treatment for Breast Cancer

et al. 2021

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Breast cancer (BC) is the most common malignant tumor in women worldwide, which seriously threatens women’s physical and mental health. In recent years, photodynamic therapy (PDT) has shown significant advantages in cancer treatment. PDT involves activating photosensitizers with appropriate wavelengths of light, producing transient levels of reactive oxygen species (ROS). Compared with free photosensitizers, the use of nanoparticles in PDT shows great advantages in terms of solubility, early degradation, and biodistribution, as well as more effective intercellular penetration and targeted cancer cell uptake. Under the current circumstances, researchers have made promising efforts to develop nanocarrier photosensitizers. Reasonably designed photosensitizer (PS) nanoparticles can be achieved through non-covalent (self-aggregation, interfacial deposition, interfacial polymerization or core-shell embedding and physical adsorption) or covalent (chemical immobilization or coupling) processes and accumulate in certain tumors through passive and/or active targeting. These PS loading methods provide chemical and physical stability to the PS payload. Among nanoparticles, metal nanoparticles have the advantages of high stability, adjustable size, optical properties, and easy surface functionalization, making them more biocompatible in biological applications. In this review, we summarize the current development and application status of photodynamic therapy for breast cancer, especially the latest developments in the application of metal nanocarriers in breast cancer PDT, and highlight some of the recent synergistic therapies, hopefully providing an accessible overview of the current knowledge that may act as a basis for new ideas or systematic evaluations of already promising results.

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Section: Discussionmentioning

confidence: 99%

Metal Nanoparticles for Photodynamic Therapy: A Potential Treatment for Breast Cancer

et al. 2021

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“…The accumulated sonosensitizer can kill tumor cells, which is mainly achieved by the generation of ROS after SDT. High levels of ROS can further promote DNA double-strand breaks, thereby destroying DNA and inducing cell apoptosis ( 34 , 35 ). Comparison of the IR780@INPs-CTX group and the US+IR780@INPs-CTX group in vitro from the ROS detection and the live/dead cell staining experiments, the IR780@INPs-CTX group without US treatment produced only a small amount of ROS, and the number of dead cells after drug treatment was also very small.…”

Section: Discussionmentioning

confidence: 99%

Cetuximab Combined With Sonodynamic Therapy Achieves Dual-Modal Image Monitoring for the Treatment of EGFR-Sensitive Non-Small-Cell Lung Cancer

et al. 2022

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BackgroundBlocking signaling by epidermal growth factor receptor (EGFR), can effectively inhibit the proliferation and differentiation of non-small-cell lung cancer (NSCLC). Additionally, an increasing number of NSCLC patients have treatment limitations caused by EGFR overexpression or mutations. Therefore, we constructed a nanotherapy platform consisting of cetuximab (CTX) to target EGFR-sensitive NSCLC with an iron tetroxide core loading the sound-sensitive agent IR780 for dual-mode imaging diagnosis by combining targeting and sonodynamic therapy (SDT) to reshape the tumor microenvironment (TME), enhance the SDT antitumor effects and improve the therapeutic effects of EGFR sensitivity.MethodsIR780@INPs were prepared by reverse rotary evaporation, CTX was adsorbed/coupled to obtain IR780@INPs-CTX, and the morphology and structure were characterized. Intracellular ROS levels and cell apoptosis first verified its killing effects against tumor cells. Then, a nude mouse lung cancer subcutaneous xenograft model was established with HCC827 cells. A real-time fluorescence IVIS imaging system determined the targeting and live distribution of IR780@INPs-CTX in the transplanted tumors and the imaging effects of the T2 sequence of the INPs by magnetic resonance imaging (MRI) 0 h, 2 h, 4 h and 6 h after administration to confirm drug efficacy.ResultsIn vitro, US+IR780@INPs-CTX produced a large amount of ROS after SDT to induce cell apoptosis, and significant cell death after live/dead staining was observed. In vivo fluorescence imaging showed the IR780@INPs-CTX was mainly concentrated in the tumor with a small amount in the liver. MRI displayed rapid enrichment of the IR780@INPs into tumor tissue 0h after injection and the T2 signal intensity gradually decreases with time without obvious drug enrichment in the surrounding tissues. In vivo, at the end of treatment, the US+IR780@INPs-CTX group showed disappearance or a continued decrease in tumor volume, indicating strong SDT killing effects.ConclusionThe combination of CTX and SDT is expected to become a novel treatment for EGFR-sensitive NSCLC.

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“…This often leads to insufficient accumulation of immunotherapeutic agents in tumor sites, which greatly inhibits the antitumor efficacy and potentially causes immune-related adverse effects ( Wang et al, 2018 ). To address this concern, Shuai’s group developed a tumor microenvironment–responsive nanodrug for combinational SDT/immunotherapy ( Huang et al, 2021 ). Nanodrugs were constructed based on lipid nanocarriers with the encapsulation of Ce6 in the core as the sonosensitizers, a conjugation of an anti-PD-L1 antibody via MMP-2–cleavable peptides, and PEG chains through an acid-labile amide bond ( Figure 1 ).…”

Section: Combinational Therapy Of Sonodynamic Therapy With Immunotherapymentioning

confidence: 99%

“… Schematic illustration of the sensitivity and in vivo performance of the pH and MMP-2 dual-sensitive PEG-coated nanodrugs for tumor-targeting combinational SDT and immunotherapy of cancer. Reproduced, with permission, from Huang et al (2021) . Copyright 2021, Elsevier.…”

Section: Combinational Therapy Of Sonodynamic Therapy With Immunotherapymentioning

confidence: 99%

Nanosonosensitizers With Ultrasound-Induced Reactive Oxygen Species Generation for Cancer Sonodynamic Immunotherapy

Cheng

Wang

Zhou

et al. 2021

Front. Bioeng. Biotechnol.

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Immunotherapy is a promising therapeutic strategy for cancer, while it has been demonstrated to encounter the issues of low immune responses and underlying immune-related adverse events. The sonodynamic therapy (SDT) that utilizes sonosensitizers to produce reactive oxygen species (ROS) triggered by ultrasound (US) stimulation can be used to ablate tumors, which also leads to the induction of immunogenic cell death (ICD), thus achieving SDT-induced immunotherapy. Further combination of SDT with immunotherapy is able to afford enhanced antitumor immunity for tumor regression. In this mini review, we summarize the recent development of nanosonosensitizers with US-induced ROS generation for cancer SDT immunotherapy. The uses of nanosonosensitizers to achieve SDT-induced immunotherapy, combinational therapy of SDT with immunotherapy, and combinational therapy of SDT with multiple immunotherapies are briefly introduced. Furthermore, the current concerns and perspectives for the development and further clinical applications of these nanosonosensitizers for SDT-combined immunotherapy of cancer are discussed.

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Nanodrug with dual-sensitivity to tumor microenvironment for immuno-sonodynamic anti-cancer therapy

Cited by 149 publications

References 46 publications

Metal Nanoparticles for Photodynamic Therapy: A Potential Treatment for Breast Cancer

Metal Nanoparticles for Photodynamic Therapy: A Potential Treatment for Breast Cancer

Cetuximab Combined With Sonodynamic Therapy Achieves Dual-Modal Image Monitoring for the Treatment of EGFR-Sensitive Non-Small-Cell Lung Cancer

Nanosonosensitizers With Ultrasound-Induced Reactive Oxygen Species Generation for Cancer Sonodynamic Immunotherapy

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