Nanodisc reconstitution and characterization of amyloid-β precursor protein C99
Bankala Krishnarjuna,
Gaurav Sharma,
Volodymyr M Hiiuk
et al.
Abstract:Amyloid precursor protein (APP) plays a pivotal role in the pathology of Alzheimers disease. Since the fragmentation of the membrane-bound APP that results in the production of amyloid-beta peptides is the starting point for amyloid toxicity in AD, it is important to investigate the structure and dynamics of APP in a near-native lipid-bilayer environment. However, the reconstitution of APP into a stable/suitable membrane-mimicking lipid environment is a challenging task. In this study, the 99-residue C-termina… Show more
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