Nanodiamonds: The intersection of nanotechnology, drug development, and personalized medicine

Ho, Dean; Wang, Chung-Huei Katherine; Chow, Edward K.

doi:10.1126/sciadv.1500439

Cited by 181 publications

(104 citation statements)

References 129 publications

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“…Sub-5 nm NPs such as NDs can be eliminated from the body renally without biodegradation and without leaving toxic residues. 588 However, larger inorganic NPs are more difficult to clear from the body. Studies have shown that AuNPs reside in macrophages after uptake and do not appear to be degraded; 589 ZnS-CdSe QDs have also been shown to remain stable in mice and rats after several months.…”

Section: In Vivo Treatment (“Particle-based Delivery”)mentioning

confidence: 99%

Diverse Applications of Nanomedicine

Pelaz¹,

et al. 2017

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The design and use of materials in the nanoscale size range for addressing medical and health-related issues continues to receive increasing interest. Research in nanomedicine spans a multitude of areas, including drug delivery, vaccine development, antibacterial, diagnosis and imaging tools, wearable devices, implants, high-throughput screening platforms, etc. using biological, nonbiological, biomimetic, or hybrid materials. Many of these developments are starting to be translated into viable clinical products. Here, we provide an overview of recent developments in nanomedicine and highlight the current challenges and upcoming opportunities for the field and translation to the clinic.

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Section: In Vivo Treatment (“Particle-based Delivery”)mentioning

confidence: 99%

Diverse Applications of Nanomedicine

Pelaz¹,

et al. 2017

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“…ND particles, which are capable of mediating improved efficacy and safety by forming complexes around the active agent while preserving its innate functionality (20)(21)(22)(23)(24)(25)(26)(27). ND safety and biocompatibility have been clearly demonstrated in numerous applications ranging from oncology to wound healing (28)(29)(30)(31)(32)(33)(34)(35).…”

Section: Significancementioning

confidence: 99%

Reducing posttreatment relapse in cleft lip palatal expansion using an injectable estrogen–nanodiamond hydrogel

Hong

Song

Lee

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Patients with cleft lip and/or palate (CLP), who undergo numerous medical interventions from infancy, can suffer from lifelong debilitation caused by underdeveloped maxillae. Conventional treatment approaches use maxillary expansion techniques to develop normal speech, achieve functional occlusion for nutrition intake, and improve esthetics. However, as patients with CLP congenitally lack bone in the cleft site with diminished capacity for bone formation in the expanded palate, more than 80% of the patient population experiences significant postexpansion relapse. While such relapse has been a long-standing battle in craniofacial care of patients, currently there are no available strategies to address this pervasive problem. Estrogen, 17β-estradiol (E2), is a powerful therapeutic agent that plays a critical role in bone homeostasis. However, E2's clinical application is less appreciated due to several limitations, including its pleiotropic effects and short half-life. Here, we developed a treatment strategy using an injectable system with photo-crosslinkable hydrogel (G) and nanodiamond (ND) technology to facilitate the targeted and sustained delivery of E2 to promote bone formation. In a preclinical expansion/relapse model, this functionalized E2/ ND/G complex substantially reduced postexpansion relapse by nearly threefold through enhancements in sutural remodeling compared with unmodified E2 administration. The E2/ND/G group demonstrated greater bone volume by twofold and higher osteoblast number by threefold, compared with the control group. The E2/ND/G platform maximized the beneficial effects of E2 through its extended release with superior efficacy and safety at the local level. This broadly applicable E2 delivery platform shows promise as an adjuvant therapy in craniofacial care of patients.nanomedicine | cleft palate | craniofacial medicine | nanodiamond | drug delivery

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“…Furthermore nanodiamonds are nontoxic cheap in production. Nanodiamonds have a greater biocompatibility and stable and easy to purify .There are ongoing researches on with doxorubicin attached nanodiamonds ( Ho et al, 2015). VNPs are one of the most advanced ad versatile nanomaterial produced by nature because of the highly symmetrical structure.…”

Section: Nanodiamondsmentioning

confidence: 99%

Nanotechnology Based Targeted Drug Delivery Systems in Breast Cancer Therapy

Weerathunga¹,

Silva²

2017

International Conference on Bioscience and Biotechnology

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Cancer is a highly heterogeneous and complex disease condition to understand because of its cellular and physiological systems. The most common cancer treatments are chemotherapy, radiotherapy and surgical excision. Out of them chemotherapy remains as the most widely used anti-cancer therapy. But unfortunately chemotherapy has plenty of drawbacks when considering its action on cancerous cells. Many chemotherapeutic drugs are highly toxic, not specific, poorly selective and less soluble because of these incidents cancer patients have severe side effects such as alopecia, renal failures, cardiac failures and etc. In order to overcome these problems in nanotechnology based targeted drug delivery system was introduced. Nanotechnology is a rapidly growing files which promote novel methods in cancer diagnosis, treatments and prognosis. In targeted drug delivery system use differently synthesized nanoparticles to reduce the drawbacks of chemotherapy. Nanoparticles such as liposomes, carbon nanotubes, virus mediated nanoparticles and nanodiamonds are some of the nanoparticles which are being discussed in this article. By using nanoparticles many of the drawbacks in conventional chemotherapy can be altered for an example by using surface functionalized nanoparticles chemotherapeutic drugs can be loaded into the particle and easily can be delivered to the exact tumor site without harming the non-cancerous cells while increasing the halflife of the drug. Likewise there are many advantages in nanotaenology based targeted drug delivery system over the conventional chemotherapy which will give a new ray of hope towards cancer patients to have a quality life.

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Nanodiamonds: The intersection of nanotechnology, drug development, and personalized medicine

Abstract: A method of developing new cancer therapies with nanodiamonds.

Cited by 181 publications

References 129 publications

Diverse Applications of Nanomedicine

Diverse Applications of Nanomedicine

Reducing posttreatment relapse in cleft lip palatal expansion using an injectable estrogen–nanodiamond hydrogel

Nanotechnology Based Targeted Drug Delivery Systems in Breast Cancer Therapy

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