Nanodiamonds as a platform for targeted delivery of chlorin-based photosensitizers to cancer cells

Gvozdev, D.A.; Ramonova, Alla A.; Slonimskiy, Yury B.; Vassiljeva, Viktoria; Nikelshparg, Evelina I.; Мойсенович, А. М.; Moisenovich, Mikhail M.; Av, Zaĭtsev; Ol’shevskaya, V. A.; Paschenko, V.Z.; Maksimov, Eugene G.

doi:10.1016/j.diamond.2021.108676

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…Maksimov et al rationally designed NDs for the targeted delivery of boronated-chloride derivatives to human A431 epidermal cancer cells. The transferrin-modified NDs surface ensured the efficient delivery of the boronated-chloride derivatives to the cells, which facilitated the photodynamic effects of the boronated-chloride derivatives on A431 cells …”

Section: Sensing and Imaging Applications Of Nds-based Sensorsmentioning

confidence: 99%

“…The transferrin-modified NDs surface ensured the efficient delivery of the boronated-chloride derivatives to the cells, which facilitated the photodynamic effects of the boronated-chloride derivatives on A431 cells. 636 Nyokong et al used positively charged phthalocyanine (2,9,16,23-tetrakis[4-(N-methylpyridinyloxy)]-phthalocyanine (ZnTPPcQ)) noncovalently linked to carbon-based nanoparticles: detonated nanodiamonds (DNDs), CDs, and GQDs to form DNDs-ZnTPPcQ, CDs-ZnTPPcQ, and GQDs-ZnTPPcQ, respectively. DNDs-ZnTPPcQ afforded the highest single linear oxygen quantum yield (0.62) compared with those of the other conjugates (Figure 15g).…”

Section: Doped Nds Sensorsmentioning

confidence: 99%

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Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging

Yang,

Xu,

et al. 2023

Chem. Rev.

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Advances in nanotechnology and nanomaterials have attracted considerable interest and play key roles in scientific innovations in diverse fields. In particular, increased attention has been focused on carbon-based nanomaterials exhibiting diverse extended structures and unique properties. Among these materials, zero-dimensional structures, including fullerenes, carbon nano-onions, carbon nanodiamonds, and carbon dots, possess excellent bioaffinities and superior fluorescence properties that make these structures suitable for application to environmental and biological sensing, imaging, and therapeutics. This review provides a systematic overview of the classification and structural properties, design principles and preparation methods, and optical properties and sensing applications of zero-dimensional carbon nanomaterials. Recent interesting breakthroughs in the sensitive and selective sensing and imaging of heavy metal pollutants, hazardous substances, and bioactive molecules as well as applications in information encryption, super-resolution and photoacoustic imaging, and phototherapy and nanomedicine delivery are the main focus of this review. Finally, future challenges and prospects of these materials are highlighted and envisaged. This review presents a comprehensive basis and directions for designing, developing, and applying fascinating fluorescent sensors fabricated based on zero-dimensional carbon nanomaterials for specific requirements in numerous research fields.

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Section: Sensing and Imaging Applications Of Nds-based Sensorsmentioning

confidence: 99%

Section: Doped Nds Sensorsmentioning

confidence: 99%

Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging

Yang,

Xu,

et al. 2023

Chem. Rev.

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“…5(b)) [127]. Finally, Gvozdev presented a clever ND design for the targeted delivery of a boronated derivative of e6 chloride to human A431 epidermoid carcinoma cells [128].…”

Section: Photothermal and Photodynamic Therapy Based On Nanodiamondmentioning

confidence: 99%

Nanodiamond in cancer theranostics

Zhu

Zhang

et al. 2023

Nano TransMed

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Nanodiamonds (NDs) are emerging as a promising platform for theranostic particles since they offer a single platform that possesses multiple important properties. These include a simple mechanism of synthesis, small size, chemical inertness, a variety of available surface functional groups, good biocompatibility, stable fluorescence, and a long fluorescence lifetime. The use of NDs to deliver anticancer drugs has been an important ND application since NDs can increase chemosensitivity, sustain drug release, and minimize drug side effects. These unique properties have stimulated the application of NDs to cancer imaging and therapy. In this review, we offer a brief introduction of ND structure and their functional properties. This is followed by a summary of recent uses of NDs for imaging purposes, including fluorescent imaging, magnetic resonance imaging (MRI), and other imaging technologies. Special concern is given to studies focusing on NDs use for anticancer drug delivery, anticancer gene delivery, photothermal and photodynamic therapies, and multifunctional combination therapy. We then discuss ND biocompatibility and toxicity in various cells and animal models. Finally, we also discuss the main problems to be solved by future research before NDs can be put to clinical use. The purpose of this review is to provide a side-by-side comparison of studies reporting ND-mediated cancer imaging therapy so that readers can assess the potential clinical applications of ND and have the background necessary to understand the clinical test results associated with ND-related therapy in animals and humans.

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“…Nanodiamonds (ND-COOH) are extensively used as drug delivery systems. Due to their chemical and physical surface properties, nanodiamonds allow for optimized delivery of various therapeutic agents [1][2][3][4], and can diffuse within cells due to their lipophilicity [5][6][7]. In addition, longer drug retention has been observed when associated with nanodiamonds compared to the drug alone.…”

Section: Introductionmentioning

confidence: 99%

The Improved Cytotoxic Capacity of Functionalized Nanodiamonds with Metformin in Breast and Ovarian Cancer Cell Lines

Acuña-Aguilar,

Conejo-Dávila,

Miki-Yoshida

et al. 2023

Processes

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Nanodiamonds (ND-COOH) are used as drug delivery systems because of their attractive properties, as they allow for optimized transport of therapeutic agents in cellular models. Metformin (MET) is a drug used in diabetes mellitus therapy and exhibits anti-cancer properties. In this study, dispersed nanodiamonds were functionalized with metformin by directly binding them to 1,6-hexanediol (ND-MET), and their effects on the cytotoxicity of breast and ovarian cancer cells were evaluated in vitro. A simple synthesis of ND-MET was performed and characterized using FT-IR, XPS, Boehm titration, RAMAN, XDR, TEM, and dynamic light scattering (DLS). Data showed an increased intensity of the C-N bond band, indicating the presence of metformin in ND-MET. We detected signals at 1427 cm−1 and 1288 cm−1 corresponding to the C-N and C-H bonds, and adsorptions at 1061 cm−1 and 3208 cm−1 corresponding to the N-O and N-H bonds, respectively. The deconvolution of the C1s binding energy was also found at 286.24 eV. The biological effects of ND-MET were tested in both SKOV3 ovarian cancer and Hs-578T and MDA-MB-231 triple-negative breast cancer cell lines. In SKOV3 cells, the IC50 for the ND-MET complex was 35 ± 14 µg/mL, while for Hs-578T and MDA-MB-231 breast cancer cells, the IC50 for ND-MET was 759 ± 44 µg/mL and 454 ± 49 µg/mL, respectively. Our data showed that ND-MET could be used as an intracellular delivery system for metformin in cancer cells. Cell viability assays evidenced a reduced viability of all cell lines in a time and dose-dependent manner, with a significant sensitivity observed in SKOV3 ovarian cancer cells treated with ND-MET.

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Nanodiamonds as a platform for targeted delivery of chlorin-based photosensitizers to cancer cells

Cited by 5 publications

References 20 publications

Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging

Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging

Nanodiamond in cancer theranostics

The Improved Cytotoxic Capacity of Functionalized Nanodiamonds with Metformin in Breast and Ovarian Cancer Cell Lines

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