Nanodiamond seeding on plasma-treated tantalum thin films and the role of surface contamination

Pobedinskas, Paulius; Degutis, Giedrius; Dexters, W.; D’Haen, Jan; Bael, Marlies K. Van; Haenen, Ken

doi:10.1016/j.apsusc.2020.148016

Cited by 25 publications

(21 citation statements)

References 59 publications

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“…95,96 While Ta inherently has high surface energy (high wettability), the metal can be produced or processed by different methods to reduce surface energy (low wettability) for use in blood contacting devices. For instance, Skoog et al 96 Similarly, other methods such as nanotube formation 97 and CF 4 gas plasma treatment (fluorination) 98 were also used to process Ta to obtain low energy surfaces.…”

Section: Surface Properties Of Tantalummentioning

confidence: 99%

A comprehensive review of biological and materials properties of Tantalum and its alloys

Mani

Porter

Grove

et al. 2022

J Biomedical Materials Res

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Tantalum (Ta) and its alloys have been used for various cardiovascular, orthopedic, fracture fixation, dental, and spinal fusion implants. This review evaluates the biological and material properties of Ta and its alloys. Specifically, the biological properties including hemocompatibility and osseointegration, and material properties including radiopacity, MRI compatibility, corrosion resistance, surface characteristics, semiconductivity, and mechanical properties are covered. This review highlights how the material properties of Ta and its alloys contribute to its excellent biological properties for use in implants and medical devices.

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Section: Surface Properties Of Tantalummentioning

confidence: 99%

A comprehensive review of biological and materials properties of Tantalum and its alloys

Mani

Porter

Grove

et al. 2022

J Biomedical Materials Res

View full text Add to dashboard Cite

show abstract

“…Prior to deposition all samples were exposed for 3 min ex-situ to a reactive oxygen gas plasma to achieve good nanodiamond (ND) seeding density using the same process conditions as in Refs [31,32]. The acetabular shells and titanium hemispheres were seeded by pouring water-based colloidal solution of ultra-dispersed ND particles (5-7 nm in diameter) over them and rinsing them afterwards with deionized water.…”

Section: Diamond Coatingmentioning

confidence: 99%

Polycrystalline Diamond Coating on Orthopaedic Implants: Realization, and Role of Surface Topology and Chemistry in Adsorption of Proteins and Cell Proliferation

Zalieckas

Mondragon

Pobedinskas

et al. 2022

Preprint

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Polycrystalline diamond has the potential to improve the osseointegration of orthopaedic implants compared to conventional materials such as titanium. However, despite the excellent biocompatibility and superior mechanical properties, the major challenge of using diamond for implants, such as those used for hip arthroplasty, is the limitations of microwave plasma chemical vapor deposition (CVD) techniques to synthesize diamond on complex-shaped objects. Here, for the first time we demonstrate diamond growth on titanium acetabular shells using surface wave plasma CVD method. Polycrystalline diamond coatings were synthesized at low temperatures (~400 °C) on three types of acetabular shells with different surface structure and porosity. We achieved the growth of diamond on highly porous surfaces designed to mimic the structure of the trabecular bone and improve osseointegration. Biocompatibility was investigated on nanocrystalline diamond (NCD) and ultrananocrystalline diamond (UNCD) coatings terminated either with hydrogen or oxygen. To understand the role of diamond surface topology and chemistry in the attachment and proliferation of mammalian cells, we investigated the adsorption of extracellular matrix (ECM) proteins, and monitored the metabolic activity of fibroblasts, osteoblasts, and bone marrow-derived mesenchymal stem cells (MSCs). The interaction of bovine serum albumin (BSA) and Type I collagen with the diamond surfaces was investigated by confocal fluorescence lifetime imaging microscopy (FLIM). We found that the proliferation of osteogenic cells was better on hydrogen terminated UNCD than on the oxygen terminated counterpart. These findings correlated with the behaviour of collagen on diamond substrates observed by FLIM. Hydrogen terminated UNCD provided better adhesion and proliferation of osteogenic cells, compared to titanium, while growth of fibroblasts was poorest on hydrogen terminated NCD and MSCs behaved similarly on all tested surfaces. These results open new opportunities for application of diamond coatings on orthopaedic implants.

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“…Prior to deposition all samples were exposed for 3 min ex-situ to a reactive oxygen gas plasma to achieve good nanodiamond (ND) seeding density [31,32]. The acetabular shells and titanium hemispheres were seeded by pouring on them water-based colloidal solution of ultra-dispersed ND particles (5-7 nm) and rinsing them after with deionized water.…”

Section: Diamond Coatingmentioning

confidence: 99%

Polycrystalline Diamond Coating on Orthopaedic Implants: Realization, and Role of Surface Topology and Chemistry in Adsorption of Proteins and Cell Proliferation

Zalieckas

Mondragon

Pobedinskas

et al. 2022

Preprint

View full text Add to dashboard Cite

Polycrystalline diamond has the potential to improve the osseointegration of orthopaedic implants compared to conventional osteo-implant materials such as titanium. However, despite the excellent biocompatibility and superior mechanical properties, the major challenge of using diamond for implants such as those used for hip arthroplasty is the limitations of microwave plasma chemical vapor deposition (CVD) techniques to synthesize diamond on complex-shaped objects. Here, for the first time we demonstrate diamond growth on titanium acetabular shells using surface wave plasma CVD method. Polycrystalline diamond coatings were synthesized at low temperatures (~400 °C) on three types of acetabular shells with different surface structure and porosity. We achieved diamond growth on highly porous surfaces designed to mimic the structure of the trabecular bone and improve osseointegration. Biocompatibility was investigated on nanocrystalline diamond (NCD) and ultrananocrystalline diamond (UNCD) coatings terminated either with hydrogen or oxygen. To understand the role of diamond surface topology and chemistry in attachment and proliferation of mammalian cells we investigated adsorption of extracellular matrix (ECM) proteins, and monitored metabolic activity of fibroblasts, osteoblasts, and bone marrow-derived mesenchymal stem cells (MSCs). The interaction of bovine serum albumin (BSA) and Type I collagen with diamond surface was investigated by confocal fluorescence lifetime imaging microscopy (FLIM). We found that proliferation of MSCs was better on hydrogen terminated UNCD than on oxygen terminated counterpart. These findings corelate to the behaviour of collagen on diamond substrates observed by FLIM. Hydrogen terminated UNCD provides better adhesion and proliferation for MSCs, compared to titanium, while growth of fibroblasts is poorest on hydrogen terminated NCD and osteoblasts behave similarly on all tested surfaces. These results open new opportunities for application of diamond coatings on orthopaedic implants.

show abstract

Nanodiamond seeding on plasma-treated tantalum thin films and the role of surface contamination

Cited by 25 publications

References 59 publications

A comprehensive review of biological and materials properties of Tantalum and its alloys

A comprehensive review of biological and materials properties of Tantalum and its alloys

Polycrystalline Diamond Coating on Orthopaedic Implants: Realization, and Role of Surface Topology and Chemistry in Adsorption of Proteins and Cell Proliferation

Polycrystalline Diamond Coating on Orthopaedic Implants: Realization, and Role of Surface Topology and Chemistry in Adsorption of Proteins and Cell Proliferation

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